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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	2797-51-5
Chemical Name	2-amino-3-chloro-1,4-naphthoquinone; Quinoclamine; ACN
Substance ID	R02-A-034-METI, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (ethylene group) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] It was classified in Category 4 from (1) - (4). [Evidence Data] (1) LD50 for rats (males): 1,360 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (2) LD50 for rats (females): 1,600 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (3) LD50 for rats (males): 500 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (4) LD50 for rats: between 300-2,000 mg/kg (CLH Report (2019)) [Reference Data, etc.] (5) LD50 for rats (females): between 200-500 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (6) LD50 for rats: between 200-500 mg/kg (EFSA (2007))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)) (2) LD50 for rats: > 2,000 mg/kg (OECD TG 402, GLP) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), EFSA (2007), CLH Report (2019))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] It was impossible to specify the category from (1), and the classification is not possible. [Evidence Data] (1) LC50 for rats (4 hours): > 0.79 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), EFSA (2007))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (GLP, occlusive, 4-hour application, 168-hour observation), one animal showed slight erythema after 1 hour, but no irritation effects were seen after 24 hours, and no skin irritation was observed in the remaining 5 animals (CLH Report (2019), Japanese Journal of Pesticide Science Vol 18, No. 1 (Pesticide Science Society of Japan, 1992)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] It was classified in Category 2 from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 9) (GLP, 14-day observation), out of 6 in the unwashed eye group after 1 hour, apparent conjunctival redness and severe chemosis were observed in all, and iritis was seen in 4. At observation after 7 days, small areas of corneal opacity remained in 2 animals but were fully reversible within 14 days (in 6 in the unwashed eye group, mean corneal opacity score: 0.9, mean iritis score: 0.9, mean conjunctival redness score: 1.8, mean chemosis score: 2.1) (CLH Report (2019)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] It was classified in Category 1A from (1). [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 10) (OECD TG 406, GLP, intradermal administration: 1.0% solution), a positive rate after challenge was 80% (8/10) (CLH Report (2019)).
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (6), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using the bone marrow cells of mice (OECD TG474, GLP, single intraperitoneal injection), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (2) In an in vivo/in vitro (ex vivo) unscheduled DNA synthesis (UDS) test (OECD TG486, GLP) using the primary cultured hepatocytes of rats dosed orally, negative results were obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)) (3) In a bacterial reverse mutation test (OECD TG471), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)、Japanese Journal of Pesticide Science Vol. 18, No. 1 (Pesticide Science Society of Japan, 2020) (Japan Crop Protection Association) (Accessed Sep. 2020)). (4) In an in vitro mammalian cell gene mutation test (OECD TG476), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019), Japanese Journal of Pesticide Science Vol. 18, No. 1 (Pesticide Science Society of Japan, 2020) (Japan Crop Protection Association) (Accessed Sep. 2020)). (5) In chromosome aberration tests using human lymphocytes (OECD TG473), positive (S9+) and negative (S9-) results were obtained (Pesticides Risk Assessment Report (2013) by Food Safety Commission of Japan, CLH Report (2019), Japanese Journal of Pesticide Science Vol. 18, No. 1 (Pesticide Science Society of Japan, 2020) (Japan Crop Protection Association) (Accessed Sep. 2020)). The Risk Assessment Report by the Food Safety Commission of Japan reported that the results of the chromosome aberration tests using human lymphocytes were quasi positive (S9+) and negative (S9-). (6) The Food Safety Commission of Japan reported that no significant genotoxicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). [Reference Data, etc.] (7) EU presented the view that in an in vivo micronucleus test with mice, there was no evidence that the test substance reached bone marrow cells (bone marrow cells were exposed) and this substance could not be judged as negative (there were restrictions on negative results), therefore, since there was a data gap in the in vivo test for this substance, no conclusion could be drawn (classification was not possible) for this hazard class (CLH Report (2019)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There were no classification results by domestic and international organizations, but based on (1) to (3), increased transitional epithelial papilloma of the urinary bladder was observed in male and female rats in the tests with rats, and an increased incidence of malignant lymphoma in female mice was suspected in the test with mice. According to the EU evaluation, an increase in adrenal pheochromocytoma in addition to an increase in bladder tumors were observed in the test with rats. The above findings were considered to present the evidence of carcinogenicity to a certain extent in two species of the test animals. Therefore, it was classified in Category 2. [Evidence Data] (1) In two two-year chronic toxicity studies with rats (dosed by feeding), an increase in neoplastic lesions was not observed in one study, while an increase in transitional epithelial papilloma of the urinary bladder was observed in the high-dose group (676 ppm) (in 0/50 males and 0/50 females in the control group and 2/50 males and 3/50 females in the dose group) in the other study (Risk Assessment Report (Food Safety Commission of Japan, 2013). (2) In a two-year carcinogenicity study with rats dosed by feeding, an increase in transitional epithelial papilloma of the urinary bladder was observed both in males and females only in the high dose group (Risk Assessment Report (Food Safety Commission of Japan, 2013). According to the CLH Report (2019), increased incidences of benign tumors of the urinary bladder (transitional epithelial papilloma) in males and females at a high dose (676 ppm) and benign tumors in the adrenal gland (pheochromocytoma) in males and females in the high dose group were observed (CLH Report (2019)). (3) In an 18-month carcinogenicity study with mice dosed by feeding, positive correlation was observed in females in a Peto test for malignant lymphoma. In comparison to the control group, a significant increase in the incidence of malignant lymphoma was observed in the low and high dose groups, while there was no significant difference in the middle dose group. The dose-response relationship was not clear, therefore, the findings were not considered to be treatment-related effects (Risk Assessment Report (Food Safety Commission of Japan, 2013). According to the CLH Report (2019), an increase of malignant lymphoma was observed only in the high dose group (females). [Reference Data, etc.] (4) In a chronic toxicity study and a carcinogenicity study with rats, an increase in transitional epithelial papilloma of the urinary bladder was observed in males and females. However, the tumor incidence was not considered to be caused by the genetic mechanism. It was considered to be possible to set the threshold values in the evaluation (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (5) EU proposed that this substance should be classified in Category 2 in the CLP classification based on the findings that benign tumors (transitional epithelial papilloma of the urinary bladder and adrenal pheochromocytoma) were observed in male and female rats and an increase in malignant lymphoma was observed in female mice (CLH Report (2019)).
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) to (4), it was classified in Category 2. [Evidence Data] (1) It was reported that in a developmental toxicity study with rats dosed by gavage (OECD TG414, GLP, gestation days 6 to 19), reduced body weight gain and decreased food consumption in parental animals; and delayed ossification, lower body weight, and an increase in fetal death rate in pups were observed at 75 mg/kg/day, but no teratogenicity was observed (Pesticides Risk Assessment Report (2013) by Food Safety Commission of Japan). The CLH Report indicated that general toxicity effects (such as reduced body weight gain, paddling of the forelimbs, nose rubbing, a decrease in mean uterus weight), an increase in preimplantation embryo loss, an increase in post-implantation embryo loss, an increased number of early intrauterine deaths, and a decrease in mean litter size were observed in parental animals; and lower fetal weight, a decrease in mean litter weight, skeletal variations and malformations (hydronephrosis (3 fetuses), subcutaneous edema (one fetus), retro-esophageal aortic arch (one fetus), and kidney misshapen (one fetus)) were observed in pups (CLH Report (2019)). (2) It was reported that in a developmental toxicity study with rabbits dosed by gavage (OECD TG414, GLP, gestation days 7 to 28), at 17.5 mg/kg/day, reduced body weight gain and a decrease in mean litter size in parental animals, and malformations (hydronephrosis (one fetus) and an increased incidence of abnormal terminal caudal vertebrae) in pups were observed (CLH Report (2019)). (3) It was reported that in a developmental toxicity study with rabbits dosed by gavage (GLP, gestation days 7 to 22), reduced body weight gain in parental animals, and an increase in late post-implantation fetal mortality and a decrease in mean number of viable fetuses in pups were observed at 17.5 mg/kg/day; and reduced body weight gain and decreased food consumption in parental animals and an increase in late intrauterine deaths after implantation, a decrease in mean number of viable fetuses, and an increase in fetal death rate in pups were observed at 30 mg/kg/day, but no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (4) It was reported that in a developmental toxicity study with rabbits dosed by gavage (OECD TG414, GLP, gestation days 6 to 18), reduced body weight gain in parental animals and delayed ossification in pups were observed, but no teratogenicity was observed at 22.5 mg/kg/day (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). The CLH Report indicated that reduced body weight gain was observed in parental animals, and an increase in the incidence of skeletal variations (increased number of caudal centra), malformations (scoliosis (one animal), spina-bifida (three animals), anomalies of the aortic arch (two animals), and sternebral fusions (three animals)) were observed in pups (CLH Report (2019)). [Reference Data, etc.] (5) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding, at 500 ppm, reduced body weight gain in parental animals (P males and F1 males and females) and reduced body weight gain in pups (F1 and F2) were observed, but no effects on fertility were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019), Japan Crop Protection Association (2020)). (6) The EFSA Report in 2007 indicated that there were teratogenic effects of this substance (rats: brachiocephalic artery absence, abnormal aortic arch, and hydronephrosis,; rabbits: hydronephrosis and renal pelvic cavitation) (EFSA (2007)). (7) Based on various developmental effects including malformations, EU proposed that this substance should be classified in Category 2 for reproductive toxicity in the CLP classification (CLH Report (2019)).
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1) to (3), it was considered to be classified in Category 3 (narcotic effects) and based on (4), it was considered to be classified in Category 3 (respiratory tract irritation). Therefore, it was classified in Category 3 (narcotic effects, respiratory tract irritation). [Evidence Data] (1) It was reported that in an acute oral toxicity test with rats, deaths, loose stool or diarrhea, salivation, lethargy, piloerection, abdominal position, prostration, dyspnea, and eye lids closure were observed at 500 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (2) It was reported that in an acute oral toxicity test with rats (OECD TG423, GLP), discolored urine, soft and discolored faeces, and anogenital soiling were observed at or above 200 mg/kg (within the range for Category 1); and salivation, lethargy, piloerection, abdominal position, unkempt fur, dark feces, and emaciation were observed at or above 500 mg/kg (within the range for Category 2) (CLH Report (2019)). (3) It was reported that in an acute oral toxicity test with rats (OECD TG420, GLP), transient chromaturia, loose stool, and ptosis were observed at or above 300 mg/kg (within the range for Category 1); and irregular breathing, salivation, lethargy, reduced locomotor activity, and prone position were observed at 2,000 mg/kg (within the range for Category 2) (CLH Report (2019)). (4) It was reported that in an acute (dust) inhalation toxicity test with rats, abnormal body posture, abnormal breathing, and rubbing of the snout or paws against the mesh of the cage were observed at 0.79 mg/L, and these signs were considered to be consistent with the responses to the exposure to an irritant dust (CLH Report (2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system, liver, adrenal gland, urinary system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1) to (4), the target organs were considered to be the blood system, liver, adrenal gland and urinary system (kidney, urinary bladder, ureter) and effects were observed at doses within the range for Category 1. Therefore, it was classified in Category 1 (blood system, liver, adrenal gland, urinary system). [Evidence Data] (1) It was reported that in a 90-day oral toxicity test with dogs dosed by capsules, hematological effects (decreases in RBC/Hb/Ht and increases in reticulocyte count, reticulocyte percentage, platelet crit, and myelopoiesis), spleen effects (congestion, an increase in extramedullary hematopoiesis, increases in absolute/relative weight (males)), liver effects (pigmentation of hepatic sinusoidal cells, bile duct hyperplasia), kidney effects (renal lipofuscinosis), and hyperplasia of urinary bladder transitional epithelia were observed at 10 mg/kg/day (within the range for Category 1) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (2) It was reported that in a two-year chronic toxicity study with dogs dosed by feeding, hematological effects (decreases in RBC/Hb/Ht, an increase in PLT), liver effects (bile duct hyperplasia, hepatic Kupffer cells, pigmentation in hepatocytes, hepatic periportal fibrosis, an increase in AST, an increase in ALP, sinusoidal distension, pigmentation in macrophages, calculi in hepatic canaliculi (females)); adrenal effects (vacuolation of cortical cells) and urinary bladder effects (pigmentation in mucosal cells) were observed at or above 50 ppm (1.4 mg/kg/day (males), 1.3 mg/kg/day (females), within the range for Category 1); and kidney effects (nephritis (cicatrix), renal tubular cyst, renal tubular enlargement (males)), liver effects (increases in ALT/total bilirubin, an increase in ALP, pigmentation in hepatic macrophages, calculi in hepatic canaliculi (males)), gall bladder effects (epithelial hyperplasia, papillary infolding), reproductive organ effects (reduced testis weight, hypo-spermatogenesis, testicular atrophy, orchitis, reduced ovarian cyclic activity), spleen effects (congestion, extramedullary hematopoiesis (males), pigmentation in macrophages (females)) were observed at 1,000 ppm (27 mg/kg/day (males), 31 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (3) It was reported that in an 18-month oral toxicity test with mice dosed by feeding, adrenal brown atrophy (females) was observed at or above 30 ppm (3.82 mg/kg/day (males), 4.48 mg/kg/day (females), within the range for Category 1); and myocardial fibrosis (males), perivasculitis in the heart, skeletal muscle, and urinary bladder (females), liver effects (chronic inflammation, brown pigmentation (females)), kidney effects (cortical scarring, an increase in the incidence of hydronephrosis), and stomach effects (hyperkeratosis, chronic inflammation) were observed at 300 ppm (40.2 mg/kg/day (males), 46.4 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (4) It was reported that in a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, renal pelvis epithelial hyperplasia and ureter epithelial hyperplasia (females) were observed at or above 52 ppm (2.82 mg/kg/day (males), 3.65 mg/kg/day (females), within the range for Category 1); and kidney effects (renal papillary necrosis and localized renal papillary necrosis (males)), urinary bladder effects (orange discoloration of serosa and epithelial hyperplasia), ureter epithelial hyperplasia (males), urethra epithelial hyperplasia, stomach chronic inflammation, and pancreatic acinar atrophy were observed at 676 ppm (37.6 mg/kg/day (males), 49.4 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2012)). [Reference Data, etc.] (5) It was reported that in a 90-day oral toxicity test with rats dosed by feeding, increases in absolute/relative spleen weight, an increased incidence of hemosiderin deposition of the spleen, increases in absolute/relative kidney weight, an increased incidence of hyaline droplets in renal tubules (males), renal tubular cloudy swelling (females), increases in absolute/relative liver weight (males), and a decrease in Ht (females) were observed at 200 ppm (14 mg/kg/day (males), 13 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (6) It was reported that in a 90-day oral toxicity test with rats dosed by feeding, a decrease in Ht/Hb (males), a decrease in RBC (females), increases in absolute/relative liver weight, and an increase in ALP (males) were observed at or above 300 ppm (21 mg/kg/day (males), 23 mg/kg/day (females), within the range for Category 2); and a decrease in RBC, an increase in neutrophil percentage (males), a decrease in Ht/Hb, an increase in WBC (females), an increase in AST, and increases in absolute/relative spleen weight were observed at 1,500 ppm (114 mg/kg/day (males), 118 mg/kg/day (females), in the range corresponding to “Not classified”) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (7) It was reported that in a 90-day oral toxicity test with rats dosed by feeding, hematological effects (such as decreases in RBC/Hb/Ht, increases in reticulocyte count/percentage, and longer APTT (males)), spleen effects (an increase in the incidence of congestion, increased extramedullary hematopoiesis and pigmentation, increases in absolute/relative weight (males)), liver effects (pigmentation of sinusoidal cells, an increase in AST (males)), kidney effects (localized nephropathy, increased pigmentation (females), an increased incidence of hyaline droplets in renal tubules (males)), and thymic atrophy were observed at 200 ppm (15.2 mg/kg/day (males), 19.1 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)). (8) It was reported that in a 90-day oral toxicity test with mice dosed by feeding, liver/spleen hemosiderosis and increases in absolute/relative testis weight were observed at 200 ppm (28 mg/kg/day (males), 30 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (9) It was reported that in a 90-day oral toxicity test with mice dosed by feeding, a decrease in Ht (females) was observed at 200 ppm (33 mg/kg/day (males), 46 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (10) It was reported that in a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, hematological effects (an increase in neutrophil percentage, and decreases in RBC/Ht and lymphocyte percentage (females)) were observed at 500 ppm (23 mg/kg/day (males), 29 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013)). (11) It was reported that in a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding, hematological effects (decreases in RBC/Hb/Ht), kidney effects (an increase in urine volume, lower urine specific gravity, pelvis/renal papillary epithelial hyperplasia), urinary bladder effects (orange discoloration of serosa, hyperplasia of transitional epithelia) and alterations in tissues in the ureter (epithelial hyperplasia) were observed at 676 ppm (38.3 mg/kg/day (males), 51.5 mg/kg/day (females), within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), CLH Report (2019)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from for 96-hour LC50 = 0.044 mg/L for fish (Oncorhynchus mykiss) (EU CLP CLH, 2019).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 because it is not rapidly degradable (BIOWIN) and due to 7-day NOErC = 0.04 mg/L for aquatic plants (Lemna minor) (EU CLP CLH, 2019).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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