GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 136849-15-5
Chemical Name N-{{[2-(Cyclopropylcarbonyl)phenyl]amino}sulfonyl}-N'-(4,6-dimethoxy-2-pyrimidinyl)urea; Cyclosulfamuron
Substance ID R02-A-052-METI
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition)
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products.
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition)
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition)
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to the element other than carbon or hydrogen (S). However, the classification is not possible due to no data.
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) LD50 for rats: > 5,000 mg/kg (Food sanitation research (Japan Crop Protection Association, 2000))
1 Acute toxicity (Dermal) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.

[Reference Data, etc.]
(1) In a bacterial reverse mutation test, negative results were reported (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(2) In a mammalian cell chromosome aberration test, negative results were reported (Food Sanitation Research (Japan Crop Protection Association, 2000)).
6 Carcinogenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.

[Reference Data, etc.]
(1) In a 24-month chronic toxicity/carcinogenicity study with rats by feeding, no evidence of carcinogenicity was observed (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(2) In an 18-month chronic toxicity/carcinogenicity study with mice by feeding, no evidence of carcinogenicity was observed (Food Sanitation Research (Japan Crop Protection Association, 2000)).
7 Reproductive toxicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.

[Reference Data, etc.]
(1) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding, no treatment-related effect was observed (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(2) It was reported that in a developmental toxicity study with rats dosed by gavage, no teratogenicity was observed (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(3) It was reported that in a developmental toxicity study with rabbits dosed by gavage, no teratogenicity was observed (Food Sanitation Research (Japan Crop Protection Association, 2000)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - [Rationale for the Classification]
Based on (1) to (3), it was classified as "Not classified" in the oral route. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes.

[Evidence Data]
(1) It was reported that in an 18-month combined chronic toxicity/carcinogenicity study with mice dosed by feeding, no effect was observed at 7,000 ppm (1,236 mg/kg/day, in the range corresponding to "Not classified") (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(2) It was reported that in a 24-month combined chronic toxicity/carcinogenicity study with rats dosed by feeding, an increase in relative liver weight and an increase in cholesterol were observed at 20,000 ppm (1,260 mg/kg/day, in the range corresponding to "Not classified") (Food Sanitation Research (Japan Crop Protection Association, 2000)).
(3) It was reported that in a 52-week chronic toxicity study with dogs dosed by feeding, an increase in ALP and an increase in serum cholesterol were observed at or above 1,000 ppm (30 mg/kg/day, within the range for Category 2) and an increase in relative liver weight and hepatocellular hypertrophy with the cholestasis in the bile canaliculi were observed at 10,000 mg/kg/day (300 mg/kg/day, in the range corresponding to "Not classified") (Food Sanitation Research (Japan Crop Protection Association, 2000)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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