Item | Information |
---|---|
CAS RN | 125-12-2 |
Chemical Name | rel-(1R,2R,4R)-Bornan-2-yl acetate |
Substance ID | R02-A-064-METI, MOE |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
It was classified in Category 4 based on a flash point of 88 deg C (Closed cup) (GESTIS (Accessed Sep. 2020)). |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 430 deg C (GESTIS (Accessed Sep. 2020)). |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) LD50 for rats: > 10,000 mg/kg (REACH registration dossier (Accessed Sep. 2020), HSDB (Accessed Oct. 2020)) (2) LD50 for rats: about 9,050 mg/kg (GESTIS (Accessed Oct. 2020), HSDB (Accessed Oct. 2020)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits: about 20,000 mg/kg (REACH registration dossier (Accessed Oct. 2020), HSDB (Accessed Oct. 2020)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" (Category 3 in UN GHS classification) from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 7-day observation), erythema was seen in 2 animals but completely disappeared within 7 days (erythema/eschar score: 0/2/2, edema score: 0/0/0) (REACH registration dossier (Accessed Sep. 2020)). |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 3) (OECD TG 405, GLP, 72-hour observation), eye irritation effects seen were fully reversible within 72 hours (corneal opacity score: 0/0/0, iritis score: 0/0/0, conjunctival redness score: 0.3/0/0, chemosis score: 0/0.3/0.3) (REACH registration dossier (Accessed Oct. 2020)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a maximization test in 25 persons, no sensitization reactions were observed after applying 10% of this substance in petrolatum (REACH registration dossier (Accessed Oct. 2020), HSDB (Accessed Oct. 2020), GESTIS (Accessed Oct. 2020)). |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using the bone marrow from mice (OECD TG 474, GLP, single dose by oral gavage, 2,000 mg/kg), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (2) In a bacterial reverse mutation test (OECD TG 471, GLP), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (3) In a gene mutation test using the Chinese hamster lung fibroblasts (V79) (OECD TG 476, GLP), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a one-generation reproduction toxicity study with rats dosed by gavage, no reproductive toxicity was observed (HSDB (Accessed Sep. 2020). (2) It was reported that in a developmental toxicity study with rats dosed by gavage (OECD TG 414, GLP, days 7 to 16 of gestation), no developmental toxicity was observed (REACH registration dossier (Accessed Sep. 2020)). |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. [Reference Data, etc.] (1) It was reported the possibility could not be ruled out that gastrointestinal disorders, central nervous system disorders (agitation/narcotic effects), and renal disorders might occur after oral intake of high doses of this substance (GESTIS (Accessed Oct. 2020)). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |
Warning |
H373 | P260 P314 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2 (kidney). [Evidence Data] (1) It was reported that in a 13-week oral toxicity study with rats dosed by gavage (OECD TG408), an increase in water intake and kidney effects (an increase in weight, a decrease in renal concentrating ability, exfoliation or vacuolation of renal tubular epithelial cells) were observed at 90 mg/kg/day (within the range for Category 2); and liver effects (vacuolation of the epithelium of the intrahepatic bile duct, an increase in liver weight) and an enlargement of the ceca were observed at 270 mg/kg/day (in the range corresponding to "Not classified") (EFSA (2016), REACH registration dossier (Accessed Sep. 2020)). [Reference Data, etc.] (2) It was reported that in a 4-week or 8-week inhalation exposure test with rats, degeneration of mitral cells of the olfactory bulb and degeneration of the olfactory epithelium were observed at 1.5 mg/L (converted guidance value: 0.467 mg/L or 0.933 mg/L, in the range corresponding to "Not classified") (GESTIS (Accessed Sep. 2020)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 > 10 mg/L and < 18 mg/L for fish (Danio rerio) (REACH registration dossier, 2021). |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" because it is not rapidly degradable (BIOWIN) and due to 72-hour NOErC = 8.54 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2021). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 because it is not rapidly degradable (BIOWIN) and due to 96-hour LC50 > 10 mg/L and < 18 mg/L for fish (Danio rerio) (REACH registration dossier, 2021). By drawing a comparison between the above results, it was classified in Category 3. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
|