Item | Information |
---|---|
CAS RN | 178961-20-1 |
Chemical Name | 2-Chloro-N-(2-ethyl-6-methylphenyl)-N-[(R)-1-methoxypropan-2-yl]acetamide; (S)-Metolachlor |
Substance ID | R02-A-070-METI |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Economy, Trade and Industry (METI) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Not classified" for this hazard class (GHS classification result in FY2020). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)) (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified in Category 1 for this hazard class (GHS classification result in FY2020). |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Not classified" for this hazard class (GHS Classification Results in FY2020). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Classification not possible." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Classification not possible" for this hazard class (GHS Classification Results in FY2020). |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Not classified" for this hazard class (GHS Classification Results in FY2020). |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system). [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified in Category 1 (central nervous system) for this hazard class (GHS Classification Results in FY2020). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Classification not possible." [Evidence Data] (1) Based on the comparison between the test results on the racemic mixture of this substance and those on the S-metolachlor, it was considered that both had similar dynamics and metabolism, and their toxicological profile and the degree of toxicity were almost the same (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor (CAS RN 51528-45-2) containing this substance (R isomer) was classified as "Classification not possible" for this hazard class (GHS Classification Results in FY2020). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] The classification is not possible from (1), (2). [Evidence Data] (1) By a comparison between the test results on the racemic mixture of this substance and those on S-metolachlor, both had equivalent dynamics and metabolism, and their toxicity profile and severity of toxicity were considered to be similar (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)). (2) Metolachlor containing this substance (R isomer) (CAS RN: 51528-45-2) was classified as "Classification not possible" for this hazard class (GHS classification result in FY2020). |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|