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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	52888-80-9
Chemical Name	S-Benzyl dipropylcarbamothioate; Prosulfocarb
Substance ID	R02-A-078-METI, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	From information on a flash point of 132 deg C (test method: unknown) (GESTIS (Accessed Dec. 2020)), it is estimated that it exceeds 93 deg C in the prescribed closed-cup method. Therefore, it was classified as "Not classified."
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 345 deg C (GESTIS (Accessed Dec. 2020)).
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] It was classified in Category 4 from (1), (2). [Evidence Data] (1) LD50 for rats (males): 1,820 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007)) (2) LD50 for rats (females): 1,960 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LC50 for rats (4 hours, mist): > 4.72 mg/L (GLP, no dead animals) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 6) (GLP, occlusive, 4-hour application, 72-hour observation), an irritation change (slight erythema) was observed in the intact skin in 1 animal at 24 hours after the removal of patches but disappeared by 72 hours, and the primary dermal irritation index (PDII) was 0.03 (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 9) (GLP, 4-day observation), conjunctival redness was observed at 1 hour after application in 4 out of 6 animals in the unwashed eye group but disappeared within 24 hours (corneal opacity score: 0/0/1/0/0/0, iritis score: 0/0/0/0/0/0, conjunctival redness score: 0/0/0/0/0/0, chemosis score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] It was classified in Category 1 from (1). [Evidence Data] (1) It is reported that in a local lymph node assay (LLNA) with mice (n = 4/group) (GLP), the stimulation index (SI values) was 1.97 (1%), 2.88 (3%), 6.31 (10%) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (5), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test using the bone marrow from mice (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). (2) In a bacterial reverse mutation test (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). (3) In a gene mutation test using the mouse lymphoma cells (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). (4) In a chromosomal aberration test using the human lymphocytes (GLP), negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). (5) Based on the in vivo and in vitro test results, it was concluded that this substance was not genotoxic (EFSA (2007)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There was no classification result by domestic and international organizations. However, based on the test results of (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a two-year combined chronic toxicity/carcinogenicity study with rats (GLP, dosed by feeding), no histopathological change was observed at doses up to 1,000 ppm (male/female: 48/57 mg/kg/day). No carcinogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)). (2) In an 18-month carcinogenicity study with mice (GLP, dosed by feeding), no histopathological change was observed at doses up to 2,400 ppm (male/female: 269/350 mg/kg/day). No carcinogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)).
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a two-generation reproduction toxicity study with rats dosed by feeding (GLP), at 1,000 ppm, findings of the kidney (glomerulonephrosis, cortex tubular dilatation, etc. (male), tubular calcification (female)) in parent animals, and low body weight in F1 and F2 offspring were observed, but no effect on fertility was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)). (2) It was reported that in a developmental toxicity study with rats dosed by gavage, at 50 mg/kg/day, reductions in body weight gain and food consumption, etc. in parent animals, and low body weight, dwarf, and unossification of the 5th sternebra were observed, but no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)). (3) In a developmental toxicity study with rabbits dosed by gavage, a decrease in the number of live fetuses was observed in offspring at a dose at which a death (1/18 animals), miscarriage (9/18 animals), etc. were observed in parent animals. It was considered that this was an effect of the death and miscarriage that were frequently observed in parent animals. It was reported that no teratogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). In the assessment of EFSA, it was determined that the increase in miscarriage was a secondary effect of the maternal toxicity, and there was no finding of contributing to classification in developmental effects in fetuses (EFSA (2007)).
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on (1) to (3), Category 2 (systemic toxicity) was considered to be applicable because effects on the unidentified target organs were observed within the dose range for Category 2, and based on (4), it was considered to be Category 3 (respiratory tract irritation). Therefore, it was classified in Category 2 (systemic toxicity) and Category 3 (respiratory tract irritation) [Evidence Data] (1) It was reported that in an acute oral toxicity test with mice, sedation, dyspnea, ataxia (female), hunchback position, lying on side, spots of the lung, spots of the liver (whitening, reddening), and reddening of the intestine were observed, and the LD50 was 3,660 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)). (2) It was reported that in an acute oral toxicity test with rats (GLP), depression, piloerection, ptosis, wet (soiled) perianal region, soiled fur, lacrimation, purple spots of the thymus, paling/reddening of the lung, darkening/paling of the liver, darkening of the spleen, soiled perianal region, yellow mass in the liver lobe, and purple small testis with white spots were observed, and the LD50 was 1,820 mg/kg (male) and 1,960 mg/kg (female) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007)). (3) It was reported that in an acute neurotoxicity test with rats by a single oral dose (GLP), at 850 mg/kg (within the range for Category 2), low body weight, a decrease in locomotor activity, and a dead male were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007)). (4) It was reported that in an acute inhalation (dust) toxicity test with rats (GLP), at 4.72 mg/L (within the range for Category 2), bloody tears, bloody nasal discharge, loose stool, a decrease in activity, unkempt fur, wet nasal speculum, and wet fur of the ventral region were observed, and most symptoms disappeared within the observation period (14 days) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). [Reference Data, etc.] (5) It was reported that in an acute dermal toxicity test with rabbits (GLP), neither death nor symptom was observed at 2,000 mg/kg (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), EFSA (2007)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver)	Warning	H373	P260 P314 P501	[Rationale for the Classification] Based on (1) to (3), the target organs were considered to be the blood system and liver, and effects were observed within the dosage range for Category 2, therefore, it was classified in Category 2 (blood system, liver). [Evidence Data] (1) It was reported that in a repeated dose 90-day oral toxicity study with rats (GLP), at 800 ppm (47 mg/kg/day (male), 52 mg/kg/day (female), within the range for Category 2), an increase in relative kidney weight was observed, and at 4,500 ppm (282 mg/kg/day (male), 305 mg/kg/day (female), in the range corresponding to "Not classified"), a death (1 male, 2 females), effects on the liver (an increase in relative weight, focal hepatocellular necrosis, hepatocyte hypertrophy, acidophilic change of the cytoplasm), diffuse necrosis of the bone marrow, and necrosis of the lymphoid tissues were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)). (2) It was reported that in a repeated dose 90-day oral toxicity study with dogs dosed by gavage (GLP), at 80 mg/kg/day (within the range for Category 2), effects on the liver (an increase in relative liver weight, an increase in ALP, an increase in absolute liver weight, hepatocyte hypertrophy, cholestasis, vacuolization of hepatocytes, increased acidophilic change of hepatocytes (female)), and effects on the hematopoietic system (erythroblastic regenerative hyperplasia of the bone marrow) were observed, and at 200 mg/kg/day (in the range corresponding to "Not classified"), effects on the blood (finding of anemia, an increase in platelet count), effects on the kidney (an increase in relative weight, nephrosis (male), tubular epithelium cell vacuolization (female)), and effects on the spleen (increased destruction of erythrocytes, hemosiderin deposit (male)) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011), EFSA (2007)). (3) It was reported that in a one-year chronic toxicity study with dogs dosed by gavage (GLP), at 80 mg/kg/day (within the range for Category 2), effects on the blood system (decreases in Hb, RBC, and MCHC, an increase in MCV), and effects on the liver (increases in absolute and/or relative liver weight, an increase in ALP) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). [Reference Data, etc.] (4) It was reported that in a two-year combined chronic toxicity/carcinogenicity study with rats dosed by feeding (GLP), at 1,000 ppm (48 mg/kg/day (male), 57 mg/kg/day (female), within the range for Category 2), an increase in urinary volume (male), a decrease in relative urine weight (male), and an increase in relative brain weight (female) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)). (5) It was reported that in an 18-month combined chronic toxicity/carcinogenicity study with mice dosed by feeding (GLP), at 2,400 ppm (269 mg/kg/day (male), 350 mg/kg/day (female), in the range corresponding to "Not classified"), low body weight was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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