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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	131475-57-5
Chemical Name	(RS)-N-[2-(3,5-Dimethylphenoxy)-1-methylethyl]-6-(1-fluoro-1-methylethyl)-1,3,5-triazine-2,4-diamine; Triaziflam
Substance ID	R02-A-088-METI
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Economy, Trade and Industry (METI)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)
Model SDS by MHLW (External link)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing fluorine and oxygen (but not chlorine) which are chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) LD50 for rats (exposure time: unknown): > 2,000 mg/kg (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] The classification is not possible because effects are unknown at a dose near the upper limit for Category 4 in (1). [Reference Data, etc.] (1) LC50 for rats: > 3,080 mg/m3 (3.08 mg/L) (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) No skin irritation was seen in a skin irritation test with rabbits (n = 6) (4-hour application, 72-hour observation) (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	[Rationale for the Classification] It was classified in Category 2B from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 6), slight irritation was seen (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in a maximization test with guinea pigs (n = 20) (intradermal administration: 1% solution), no skin sensitization was seen (Document for Evaluating Safety of Agricultural Chemicals, Central Environment Council (2011)).
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test with the ICR mice, negative results were reported (Pesticide safety evaluation materials (Central Environment Council, 2011)). (2) In a bacterial reverse mutation test, negative results were reported (Pesticide safety evaluation materials (Central Environment Council, 2011)). (3) It was reported that in a chromosomal aberration test using the cultured mammalian cells, this substance was positive at doses that were cytotoxic, but in an in vivo micronucleus test using chromosomal aberrations as an indicator, negative results were obtained in all dose groups. Therefore, this substance was not considered to be genotoxic in vivo (Pesticide safety evaluation materials (Central Environment Council, 2011)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data. In (1) and (2), slight developmental toxicity effects were only observed in pups at doses at which general toxicity effects were observed in maternal animals, but there was no data available on effects on fertility. [Evidence Data] (1) It was reported that in a developmental toxicity study with rats dosed by gavage, at a dose at which general toxicity effects (2/30 cases of death, a decrease in defecation, staining in the anogenital area, alopecia, reduced body weight gain, a reduction in food consumption) were observed in parental animals, slight developmental effects (lower body weight, a delay in ossification and skeletal variations (a delay in ossification of the vertebral arch, no ossification of the sternebrae, an increasing trend in incidence of the 14th rudimentary ribs)) were observed in pups (Pesticide safety evaluation materials (Central Environment Council, 2011)). (2) It was reported that in a developmental toxicity study with rabbits dosed by gavage, at a dose at which general toxicity effects (1/23 case of death, a decrease in body weight, reduced body weight gain, a reduction in food consumption) were observed in parental animals, slight developmental effects (an increased number of fetuses having skeletal variations (bent hyoid arch)) were observed in pups (Pesticide safety evaluation materials (Central Environment Council, 2011)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes. [Evidence Data] (1) It was reported that in a repeated dose 90-day oral toxicity study with rats dosed by feeding, higher serum CHOL (cholesterol) levels, higher absolute and relative weight of the liver and the thyroid/parathyroid (as a percentage of body weight or brain weight), and higher serum PL (phospholipid) levels in males were observed at or above 1,250 ppm (90.7 mg/kg/day (males), 97.3 mg/kg/day (females), within the range for Category 2); and reduced body weight gain, lower food consumption, lower water intake, lower Hb (hemoglobin) levels, lower MCV (mean corpuscular volume), higher serum CHOL, PL, TP (total protein), ALB (albumin), and GLOB (total globulin) levels, higher absolute and relative weight of the liver and the thyroid/parathyroid (as a percentage of body weight or brain weight), and urine granular casts, vacuolation (fatty changes) of hepatocytes and renal hyaline casts in males and alopecia (20%) and lower MCH (mean corpuscular hemoglobin) levels in females were observed at 5,000 ppm (350 mg/kg/day (males), 376 mg/kg/day (females), in the range corresponding to "Not classified") (Pesticide safety evaluation materials (Central Environment Council, 2011)). (2) It was reported that in a repeated dose 90-day neurotoxicity test with rats dosed by feeding, no effect was observed at 5,000 ppm (306 mg/kg/day (males), 348 mg/kg/day (females), in the range corresponding to "Not classified") (Pesticide safety evaluation materials (Central Environment Council, 2011)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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