GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 122-18-9
Chemical Name N-Benzyl-N,N-dimethylhexadecan-1-aminium,chloride(1:1)
Substance ID R02-A-094-METI
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Economy, Trade and Industry (METI)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link)  
Model SDS by MHLW (External link)  
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition)
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products.
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition)
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition)
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - No data available. Besides, there is information that it is combustible (GESTIS (2020)).
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not classified (Not applicable)
-
-
- - The substance is an organic compound containing chlorine (but not fluorine or oxygen), which is chemically bonded to the element other than carbon or hydrogen (N). However, because this is an ionic bond and does not contribute to oxidization, it was classified as "Not classified."
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) Alkyl (C=12-16) (benzyl) (dimethyl) ammonium chloride (CAS RN: 68424-85-1), a mixture containing this substance, was classified in Category 3 for this hazard class (GHS classification in FY2020).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) Alkyl (C=12-16) (benzyl) (dimethyl) ammonium chloride (CAS RN: 68424-85-1), a mixture containing this substance, was classified in Category 3 for this hazard class (GHS classification in FY2020).
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) Alkyl (C=12-16) (benzyl) (dimethyl) ammonium chloride (CAS RN: 68424-85-1), a mixture containing this substance, was classified in Category 2 for this hazard class (GHS classification in FY2020).
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
[Rationale for the Classification]
It was classified in Category 1 from (1) based on expert judgment.

[Evidence Data]
(1) Alkyl (C=12-16) (benzyl) (dimethyl) ammonium chloride (CAS RN: 68424-85-1), a mixture containing this substance, was classified in Category 1 for this hazard class (GHS classification result in FY2020).

[Reference Data, etc.]
(2) It is reported that as a result of applying 150 microg of this substance to the human skin for 3 days, slight irritation was seen (REACH registration dossier (Accessed Dec. 2020)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
[Rationale for the Classification]
It was classified in Category 1 from (1) based on expert judgment.

[Evidence Data]
(1) Alkyl (C=12-16) (benzyl) (dimethyl) ammonium chloride (CAS RN: 68424-85-1), a mixture containing this substance, was classified in Category 1 for this hazard class (GHS classification result in FY2020).

[Reference Data, etc.]
(2) It is reported that in an eye irritation test with rabbits (n = 5), after 15-time applications of a 0.002% solution of this substance at 5-minute intervals, slight conjunctival redness was observed after 4 hours but was fully reversible within 24 hours (REACH registration dossier (Accessed Dec. 2020)).
(3) In a test in which eye irritation was evaluated by measuring in-vitro corneal transepithelial electrical resistance (TER) in rabbits, no significant changes in TER were seen in a 0.0025% solution. In the case of 0.005% and 0.01%, TER decreased to 61.1% and 43.7%, respectively, compared with the control group, and this substance exhibited moderate corneal barrier dysfunction (REACH registration dossier (Accessed Dec. 2020)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) It is reported that in a patch test in 11,237 patients with suspected contact allergy, after 48-hour application of petrolatum ointment containing 0.1% of this substance, the positive rate was 0.2% (26/11,237) after 72 hours (REACH registration dossier (Accessed Dec. 2020)).
5 Germ cell mutagenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.

[Reference Data, etc.]
(1) In a bacterial reverse mutation test, negative results were reported (REACH registration dossier (Accessed Dec. 2020)).
6 Carcinogenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.

[Reference Data, etc.]
(1) It was reported that in a two-generation reproduction toxicity study for didecyldimethylammonium chloride (CAS RN 7173-51-5) used as the test substance with rats dosed by feeding, lower body weight and food consumption in parental animals and reduced body weight gain in pups were observed at 100 mg/kg/day. In a subacute oral toxicity test (13 weeks) for benzyltrimethylammonium chloride (CAS RN 56-93-9) used as the test substance with mice dosed by gavage, no effects on male and female reproductive organs, sperm test results, and estrus cycle of females were observed. Based on these findings, the REACH registration dossier indicated that this substance was not likely to be classified as a reproductive toxicant (REACH registration dossier (Accessed Dec. 2020)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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