Item | Information |
---|---|
CAS RN | 7791-08-4 |
Chemical Name | Antimony chloride oxide |
Substance ID | R02-A-009-MHLW |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | It contains a metalloid (Sb), but the classification is not possible due to no data. |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen and halogen, but the classification is not possible due to no data. |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound. It was classified as "Not classified." |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) Skin disease and disease in the anterior part of the eye are described for antimony and its compounds in Article 35 in the Ordinance of Enforcement of the Labor Standards Act (Ordinance of Enforcement of the Labor Standards Act, Article 35 Appended Table (1996)). (2) It is described that as detailed symptoms due to exposure to antimony and its compounds, they are irritating or corrosive to the skin and eye and may cause dermatitis (Investigation report to collect medical knowledge on occupational disease (2015)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1) - (3). [Evidence Data] (1) Skin disease and disease in the anterior part of the eye are described for antimony and its compounds in Article 35 in the Ordinance of Enforcement of the Labor Standards Act (Ordinance of Enforcement of the Labor Standards Act, Article 35 Appended Table (1996)). (2) It is described that as detailed symptoms due to exposure to antimony and its compounds, they are irritating or corrosive to the skin and eye and may cause dermatitis (Investigation report to collect medical knowledge on occupational disease (2015)). (3) This substance was classified in Category 1 in skin corrosion/irritation. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. [Reference Data, etc.] (1) Antimony chloride (antimony trichloride) (CAS RN 10025-91-9) was classified in Category 2 (GHS Classification Results in FY2015). (2) Sodium hypochlorite (CAS RN 7681-52-9) was classified as "Not classified" (GHS Classification Results in FY2020). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] No data available and classification was not possible. [Reference Data, etc.] (1) IARC classified hypochlorites in Group 3 (IARC 52, 1991), although this substance was not included. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no data of this substance, but since it was considered that this substance dissociated into hypochlorite ions and antimony ions in an aqueous solution, classification was examined based on the data of hypochlorous acid (CAS RN 7790-92-3) and aqueous antimony. Based on the data of hypochlorous acid, it was considered that there were generally no reproductive effects, but since there was no data of developmental toxicity solely due to the administration during the organogenesis period, it was determined that classification was not possible due to lack of data. As for antimony ions, classification was not possible. From the above, classification was not possible due to lack of data. [Evidence Data] (1) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, alterations in body weight, sperm count, sperm motility or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-dependent effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (2) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) It was stated as follows in the EURAR (2007). There was no data on sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that although limited data was available, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. Similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). (4) As for reproductive effects of antimony salt, classification was not possible for antimony chloride (antimony trichloride) (CAS RN 10025-91-9) (GHS Classification Results in FY2015). |
8 | Specific target organ toxicity - Single exposure | Category 1 (lung, cardiovascular system), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
[Rationale for the Classification] There was no report on this substance, but it was classified in Category 1 (lung, cardiovascular system) and Category 3 (narcotic effects) based on (1) and (2) which provided information on antimony compounds. [Evidence Data] (1) As for antimony and its compounds, it was stated that pneumonitis, and cardiac and hematological disorders were anticipated due to acute exposure to high concentrations (ACGIH (7th, 2001)). (2) Subjective symptoms such as headache, dizziness, and emesis, skin lesions, anterior eye disease, myocardial dysfunction, or gastrointestinal dysfunction caused by antimony and its compounds were specified as employment-related diseases stated in Appended Table 1-2, Ordinance for Enforcement of the Labor Standards Act (Ministry of Labour Notification No. 33, 1996)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (lung, cardiovascular system, gastrointestinal tract) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] There was no information on this substance itself, but classification was examined based on the information on sodium hypochlorite (CAS RN 7681-52-9) and antimony compounds. Based on (3) and (4), repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was considered to be low, but based on the information on adverse effects of antimony compounds in (1) and (2), it was classified in Category 1 (lung, cardiovascular system, gastrointestinal tract). [Evidence Data] (1) As for antimony and its compounds, it was stated that pneumonitis, and cardiac and hematological disorders were anticipated due to acute or chronic exposure to high concentrations (ACGIH (7th, 2001)). (2) Subjective symptoms such as headache, dizziness, and emesis, skin lesions, anterior eye disease, myocardial dysfunction, or gastrointestinal dysfunction caused by antimony and its compounds were specified as employment-related diseases stated in Appended Table 1-2, Ordinance for Enforcement of the Labor Standards Act (Ministry of Labour Notification No. 33, 1996)). (3) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only reduced body weight gain which was considered to be associated with reduced water consumption, was observed when rats and mice were dosed for 90 days and 2 years (EURAR (2007), SIAR (2006)). (4) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 8 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|