NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	10233-03-1
Chemical Name	Magnesium hypochlorite
Substance ID	R02-A-010-MHLW
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	It contains a metal (Mg), but the classification is not possible due to no data.
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen and halogen, but the classification is not possible due to no data. Besides, barium hypochlorite, lithium hypochlorite, and calcium hypochlorite are classified in Category 2 according to the UN numbers in this hazard class.
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] There are no data on this substance itself, but it was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) Because hypochlorite ion is alkaline, like calcium hypochlorite (CAS RN 7778-54-3), which is corrosive to the skin (AICIS (formerly, NICNAS IMAP) (2015)), this substance was also considered to be corrosive to the skin.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) This substance was classified in Category 1 in skin corrosion/irritation (GHS classification in 2020).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] There was no information on this substance itself, but since this substance was considered to dissociate into hypochlorite ions and magnesium ions in aqueous solution, classification was examined based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compounds. Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) As for in vivo of sodium hypochlorite (CAS RN 7681-52-9), in a micronucleus test using the bone marrow of mice dosed by intraperitoneal injection or oral administration, negative results were reported; in a mammalian bone marrow chromosomal aberration test with mice dosed by oral administration, negative results were reported; and in a DNA damage test with rats dosed by oral administration, negative results were reported (EURAR (2007), NTP TR392 (1992), Patty (6th, 2012)). (2) As for in vitro of sodium hypochlorite, in a bacterial reverse mutation test, and a mammalian cell chromosome aberration test, negative and positive results were reported (EURAR (2007), NTP TR392 (1992)), and in a sister chromatid exchange test, positive results were reported (EURAR (2007)). (3) As for in vivo of magnesium chloride (CAS RN 7786-30-3), in a micronucleus test using the bone marrow of mice dosed by intraperitoneal injection, negative results were reported (SIAR (2011)). (4) As for in vitro of magnesium chloride, in a bacterial reverse mutation test, and a mammalian cell chromosome aberration test, negative results were reported (SIAR (2011)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] No data available. [Reference Data, etc.] (1) The IARC classified hypochlorites in Group 3 (IARC 52 (1991)), although this substance was not included.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] There was no data on this substance, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in an aqueous solution, classification was examined based on the data of hypochlorous acid (CAS RN 7790-92-3) and water-soluble magnesium. As for hypochlorous acid, it was considered that there were generally no reproductive effects, but since there was no data of developmental toxicity at the administration only during the organogenesis period, it was determined that classification was not possible due to lack of data. As for magnesium ions, there were data in (4), and no reproductive effects were observed, but since the test was a screening test, and there was no data of developmental toxicity in the case of administration during the organogenesis period only, classification was not possible due to lack of data. From the above, classification was not possible due to lack of data. [Evidence Data] (1) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, alterations in body weight, sperm count, sperm motility or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-dependent effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (2) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) It was stated as follows in the EURAR (2007). There was no data on sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that although limited data was available, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. Similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). (4) As for reproductive effects of magnesium salt, the information on magnesium chloride (CAS RN 7786-30-3) was obtained. In a reproduction/developmental toxicity screening test (OECD TG 421) by oral administration of magnesium chloride to rats dosed by gavage, no reproductive effects or developmental effects were observed at the highest dose (1,000 mg/kg/day) at which toxicity in parent animals (soft stool, diarrhea, salivation, decreased body weight gain) was observed (SIAR (2011)).
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] There was no information on this substance itself, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compound. Based on (1) and (2), it was classified in Category 3 (respiratory tract irritation). Effects on the gastrointestinal system were not adopted because they were considered to be attributable to irritation by sodium hypochlorite. [Evidence Data] (1) In humans exposed to drugs containing sodium hypochlorite (CAS RN 7681-52-9), eye and upper respiratory tract irritations were observed (EURAR (2007)). (2) Accidental ingestion of a small amount of chlorine bleach containing sodium hypochlorite could cause esophageal irritation, and in high concentration, it could cause severe damage to the upper respiratory tract and even death (AICIS (previous NICNAS) IMAP (2014)). [Reference Data, etc.] (3) A 66-year-old woman who accidentally ingested chlorine bleach containing sodium hypochlorite (unknown quantity) died of cardiac arrest in 4.5 hours, and autopsy revealed esophageal and gastric mucosal erosions, perforations at the gastro-esophageal junction, and extensive necrosis of adjacent soft tissue (AICIS (previous NICNAS) IMAP (2014)). (4) In a child who accidentally ingested bleach containing sodium hypochlorite and swallowed small amounts, discomfort and vomiting by stomach irritation were observed (IPCS PIM 495 (1998)). (5) Gastrointestinal irritation with emesis and vomiting occurred with accidental ingestion of sodium hypochlorite, and corrosive injury of the stomach and hypernatremia with hyperchloremic acidosis occurred with ingestion of a large amount of sodium hypochlorite (IPCS PIM 495 (1998)). (6) Chlorine gas released from sodium hypochlorite caused burning in the throat and coughing. High levels of exposure could lead to swelling and obstruction of the airway, and in serious cases, noncardiogenic pulmonary edema could occur (IPCS PIM 495 (1998)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] There was no information on this substance itself, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compound. Based on (1) and (2), it was considered that repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was low, but since effects on the respiratory organs due to inhalation exposure were unknown, it was determined that classification was not possible. [Reference Data, etc.] (1) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only reduced body weight gain which was considered to be associated with reduced water consumption, was observed when rats and mice were dosed for 90 days and 2 years (EURAR (2007), SIAR (2006)). (2) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 8 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)). (3) As for magnesium chloride (CAS RN 7786-30-3), it was reported that in a reproduction/developmental toxicity screening test with rats (dosed by gavage for 42 days for males and 14 days for females), at 500 mg/kg/day (converted guidance value: males/females: 233/78 mg/kg/day, exceeding Category 2 for males, and within the range for Category 2 for females), soft stool, diarrhea, and salivation were observed (SIAR (2011)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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