GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 799247-52-2
Chemical Name Methyl [2-chloro-5-((E)-1-{[(6-methyl-2-pyridyl)methoxy]imino}ethyl)benzyl]carbamate; Pyribencarb
Substance ID R02-A-023-MHLW, MOE
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. It was classified as "Not classified."
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
10 Pyrophoric solids Not classified
-
-
- - It was classified as "Not classified" because it is estimated that it does not ignite at normal temperatures from information that it does not decompose at up to 150 deg C (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16 Corrosive to metals Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
[Rationale for the Classification]
It was classified in Category 4 from (1).

[Evidence Data]
(1) LD50 for rats: females: 300-2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018))
1 Acute toxicity (Dermal) Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) LD50 for rats: > 2,000 mg/kg (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018))
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) LC50 for rats (nose exposure, 4 hours): > 4.91 mg/L (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018))
2 Skin corrosion/irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) No irritation was observed in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).
3 Serious eye damage/eye irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) In an eye irritation test with rabbits, conjunctival reactions were observed from 1 hour after the end of applying the sample in all the animals, but the mean score at 24/48/72 hours after application was <= 1, and all signs disappeared after 72 hours (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) It was negative in a skin sensitization test with guinea pigs (maximization test, intradermal administration 5%) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).
5 Germ cell mutagenicity Not classified
-
-
- - [Rationale for the Classification]
Based on (1) to (3), it was classified as "Not classified."

[Evidence Data]
(1) As for in vivo, in a micronucleus test using the bone marrow cells of mice, negative results were reported (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018))
(2) As for in vitro, in a bacterial reverse mutation test, negative results were obtained, and in an in vitro mammalian cell chromosome aberration test, there was a slight increase in the incidence of cells having structural aberrations at the highest treatment concentration (Same as above)
(3) It was summarized that this substance was not considered to have genotoxicity, which might be a problem for a living organisms (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
6 Carcinogenicity Not classified
-
-
- - [Rationale for the Classification]
There are no classification results by domestic and international organizations. There was no report available on humans. Based on (1), it was classified as "Not classified."

[Evidence Data]
(1) In carcinogenicity studies by diet administration of this substance to male and female rats for two years and male and female mice for 18 months, no effect of the administration on the incidence of neoplastic lesions was observed and no carcinogenicity was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
7 Reproductive toxicity Not classified
-
-
- - [Rationale for the Classification]
Based on (1) to (3), it was classified as "Not classified."

[Evidence Data]
(1) In a two-generation reproduction study with rats dosed by feeding, reduced body weight gain, increases in absolute and relative liver weight, centrilobular hypertrophy of hepatocytes, etc. were observed in both parental animals and pups, but no effect on fertility was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
(2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 19 of gestation, even at a dose at which stained fur around the external urethral opening, reduced body weight gain, etc. were observed in dams, no effect was observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
(3) In a developmental toxicity study with female rabbits dosed by gavage on days 6 to 27 of gestation, at a dose at which maternal toxicity effects (premature delivery (4 cases), reduced body weight gain, a decrease in food consumption, and a decrease in placental weight) were observed, lower body weight, skeletal variations (an increase in the percentage of fetuses and the incidence of litters having unossified sternebrae and a decrease in ossified sternebrae) were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data. In the Reference Data (1), respiratory murmur was observed in only one case and it was not adopted as a rationale for the classification.

[Reference Data, etc.]
(1) In a four-hour inhalation exposure test with rats, at 4.91 mg/L (within the range for Category 2), an increase in respiration rate, respiratory murmur (1 case), hunched posture, piloerection (1 case), and red/brown staining around the head (2 cases) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018))
9 Specific target organ toxicity - Repeated exposure Category 2 (liver)


Warning
H373 P260
P314
P501
[Rationale for the Classification]
There was no report on hazard by repeated exposure to this substance in humans. In experimental animals, based on (1), at doses for Category 2, toxicity effects on the liver were observed. Therefore, it was classified in Category 2 (liver).

[Evidence Data]
(1) It was reported that in a one-year oral toxicity study with rats dosed by feeding, at or above 500 ppm (males/females: 19.8/25.5 mg/kg/day, both within the range for Category 2), diffuse fatty change of hepatocytes was observed in males; and at 2,500 ppm (males/females: 103/130 mg/kg/day, both exceeding Category 2), a decrease in brown pigmentation of the spleen was observed, and furthermore, an increase in BUN, diffuse hypertrophy of hepatocytes, and thyroidal colloidal alterations in males, and an increase in total cholesterol and a decrease in triglyceride in females were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).

[Reference Data, etc.]
(2) In a 90-day oral toxicity study with mice dosed by feeding, at or above 600 ppm (males/females: 76.8/90.8 mg/kg/day, both within the range for Category 2), hypertrophy of hepatocytes was observed; and at 3,600 ppm (males/females: 463/531 mg/kg/day, both exceeding Category 2), a decrease in triglyceride, dilatation of the duodenum lumen, and single cell necrosis of hepatocytes were observed, and furthermore, in females, increases in ALT and BUN were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
(3) As a result of liver drug metabolic enzyme induction studies with rats (dosed by feeding for 14 days), the effects of the administration of this substance on the rat liver, such as increases in absolute and relative liver weight and centrilobular hypertrophy of hepatocytes, were considered to be due to induction of liver drug metabolic enzymes (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
(4) It was reported that in a 90-day oral toxicity study with dogs dosed by capsules, emesis, loose stools, etc. were observed at or above 30 mg/kg/day (within the range for Category 2) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 48-hour EC50 = 0.6 mg/L for crustacea (Daphnia magna) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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