NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	3333-52-6
Chemical Name	Tetramethyl succinonitrile
Substance ID	R02-B-008-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006 FY2010
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (ICSC (1999)).
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] It was classified in Category 2 from (1) - (3). [Evidence Data] (1) LD50 for rats: 30 mg/kg (ACGIH (7th, 2019)) (2) LD50 for rats: 38.9 mg/kg (ACGIH (7th, 2019), HSDB (Access on April 2020)) (3) LD50 for rats: 27 mg/kg (GESTIS (Access on April 2020))
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	[Rationale for the Classification] Because LD50 was considered to be within the range for Category 2 (50-200 mg/kg) from (1), (2), it was classified in Category 2. The classification result was changed from the previous classification by the use of a new information source. [Evidence Data] (1) The lethal dose was 100 mg/kg in a dermal application test in rabbits (ACGIH (7th, 2019)). (2) LDLo for rabbits: 79.4 mg/kg (ACGIH (7th, 2019))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] There were data in (2), and LC50 was considered to be within the range for Category 2 (0.05-0.5 mg/L) from (1). Therefore, it was classified in Category 2. Besides, because exposure concentrations were higher than the saturated vapor pressure concentration (0.00843 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) In an inhalation exposure test (2-3 hours) in rats, a lethal dose was 60 ppm (0.334 mg/L) (converted 4-hour equivalent value from 2 hours: 0.167 mg/L, converted 4-hour equivalent value from 3 hours: 0.25 mg/L) (ACGIH (7th, 2019)). (2) The minimum lethal concentration was 235 mg/m3 (0.235 mg/L) in an inhalation exposure test (4 hours) in rats (ACGIH (7th, 2019)). (3) Vapor pressure of this substance: 0.00115 mmHg (25 deg C) (converted value for the saturated vapor pressure concentration: 0.00843 mg/L) (HSDB (Access on April 2020))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) No irritation reactions were observed during the 7-day observation period in a skin irritation test in which this substance (500 mg) was applied to rabbits for 24 hours (GESTIS (Access on April 2020)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In an eye irritation test in which this substance (100 mg) was applied to rabbits, slight conjunctival redness occurred and persisted for 48 hours (GESTIS (Access on April 2020)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) As for in vivo, there are no test data on this substance. (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test and a mouse lymphoma test (ACGIH (7th, 2019), CEBS (Access on April 2020)).
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data. [Reference Data, etc.] (1) In a test with hamsters parenterally dosed by single injection during the organogenesis period, at a dose at which maternal toxicity (death: 37%, subnormal temperature) was observed, a reduction in crown-rump length and an increase in exencephaly were observed in fetuses (ACGIH (7th, 2019), HSDB (Access on April 2020)). (2) In a teratogenicity test with hamsters using this substance or succinonitrile (CAS RN 110-61-2), there was a clear potential for teratogenic effects to occur from metabolically released cyanide in the group dosed with succinonitrile. Meanwhile, in the group dosed with this substance, no teratogenic effects were induced, and no cyanide was detected in the blood (GESTIS (Access on April 2020)).
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] As for humans, there was information in (1) to (3), and effects on the central nervous system were suggested. Although there was insufficient information on exposure for all of them, since the information on test animals in (4) showed central nervous system effects of this substance, it was classified in Category 1 (central nervous system). [Evidence Data] (1) It was reported that in a plant making vinyl foam products in Germany, 12 out of 16 workers (9 men, 7 women) complained of a headache, and 5 workers experienced convulsions, however, since the concentration of exposure to this substance was not measured, and there was a possibility that the workers were exposed to other chemical compounds including vinyl chloride monomer and azoisobutyronitrile, it was not known whether the effects were solely due to to this substance (ACGIH (7th, 2019)). (2) Five accident cases in which foam plastic manufacturing workers suffered loss of consciousness and convulsions were reported, and other symptoms such as headaches, salivation, impaired sense of taste, nausea, and vomiting were also reported, but no detailed data on exposure was reported (HSDB (Access on April 2020), GESTIS (Access on April 2020)). (3) It was reported that in studies on 16 workers who allegedly exhibited symptoms due to exposure to vapor (concentration was unknown) of this substance, they suffered headaches, dizziness, nausea, vomiting, unpleasant taste sensations, frothy spittle, respiratory distress, insomnia, lapses of consciousness, and convulsions, and 2 subject workers lost consciousness after acute exposure. Although the presence of this substance in the workplace had not been proven, the authors speculated that this substance was released as a thermal decomposition product of azoisobutyronitrile which was used as a PVC foaming agent (HSDB (Access on April 2020)). (4) Animals (rats and guinea pigs) orally dosed with this substance developed violent convulsions and asphyxia, and died within 1 minute to 5 hours after the onset of the convulsions. Although the minimum dose at which the effects were observed was not described, since the LD50 values were 27-38.9 mg/kg, they were considered to be effects within the range for Category 1 at around the LD50 values (ACGIH (7th, 2019), GESTIS (Access on April 2020)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1 (central nervous system). [Evidence Data] (1) In a study of 44 workers at a polyvinyl chloride processing plant in Switzerland, convulsions were reported in 4 workers involved in cutting and sanding PVC boards. Four of the workers had normal blood glucose levels, but exhibited reversible pathologic electroencephalograms. Other symptoms reported by the workers were headaches (13 workers), dizziness (8 workers), and unpleasant taste sensations (7 workers), and 16 workers were hypoglycemic. The concentration of this substance in recirculated exhaust air was 38 mg/m3, and the concentration detected by a personal sampler was 11 mg/m3 (ACGIH (7th, 2019)). [Reference Data, etc.] (2) It was reported that in a 90-day test with orally dosed rats, lowered blood glucose levels, enlarged hepatocytes, etc. were observed at 10 mg/kg/day (ACGIH (7th, 2019), HSDB (Access on April 2020)). (3) The ACGIH set TLV-TWA in order to minimize headache, nausea, and central nervous system toxicity that could result in convulsions and hypoglycemia (ACGIH (7th, 2019)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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