NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	107-94-8
Chemical Name	3-Chloropropionic acid
Substance ID	R02-B-037-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2009
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (GESTIS (Access on May 2020)).
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) LDLo for mice: 1,040 mg/kg (GESTIS (Access on May 2020))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)). (2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1) - (3). [Evidence Data] (1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)). (2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)). (3) This substance was classified in Category 1 in skin corrosion/irritation.
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) As for in vitro, it was reported to be positive in a bacterial reverse mutation test (Mutagenicity Test Data of Existing Chemical Substances based on the toxicity investigation system of the Industrial Safety and Health Law (Access on July 2020)). [Reference Data, etc.] (2) This substance is the chemical substance for which mutagenicity was recognized based on Article 57-3 of the Industrial Safety and Health Law.
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. Because a trend toward an increased tumor incidence was observed in female rats in (1), and the carcinogenicity of this substance was shown, it was classified in Category 2. By taking the results in female rats as limited evidence of carcinogenicity, the classification result was changed. [Evidence Data] (1) In carcinogenicity tests by 2-year drinking water administration of this substance to male and female rats and mice, increased incidences of endometrial stromal polyps and endometrial stromal sarcoma were observed in female rats, and the carcinogenicity of this substance was shown in female F344/DuCrj (Fischer) rats. In mice, no increase in tumor incidences due to the administration of this substance was found in males or females, and no carcinogenicity of this substance was shown in male and female Crj: BDF1 mice (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1994)).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1 (respiratory organs). A new information source was used and the classification result was changed from the previous classification. [Evidence Data] (1) Inhalation of this substance is expected to entail strong irritations in the area of the respiratory tract (burning sensations of the mucosae, respiratory disorders, cough etc.), and there is a risk of severe damage of the respiratory tract (inflammation, pharyngeal/pulmonary edema) (GESTIS (Access on May 2020)). [Reference Data, etc.] (2) Accidental oral intake of this substance must be assumed to involve a high risk due to the possible local corrosive effects alone (damage of the digestive tract) (GESTIS (Access on May 2020)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] There was no finding in the oral route that should be adopted as a rationale for the classification. There was no data available in the other administration routes, and it was classified as "Classification not possible." [Evidence Data] (1) In a 13-week toxicity test with rats dosed by drinking water, at the maximum dose of 8,000 ppm (1,600 mg/kg/day, exceeding Category 2), a decrease in water intake due to the repellent action, a decrease in food consumption, and reduced body weight gain were observed, and in a blood biochemical examination, findings indicating nutritional disorders were observed (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1994)). (2) In a 13-week toxicity test with mice dosed by drinking water, as was the case with rats, a decrease in water intake due to the repellent action and reduced body weight gain were observed at or above 4,000 ppm (800 mg/kg/day, exceeding Category 2), and in a blood biochemical examination, findings indicating nutritional disorders were observed at 8,000 ppm (1,600 mg/kg/day, exceeding Category 2)) (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1994)). (3) In a 104-week toxicity test with rats dosed by drinking water, at 7,200 ppm (900mg/kg/day, exceeding Category 2), eosinophilic changes in the olfactory epithelium of the nasal cavity and retinal atrophy were observed in males and females and bile duct hyperplasia was observed in males (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1994)). (4) In a 104-week toxicity test with mice dosed by drinking water, exfoliation of the epithelium of the renal pelvis was observed in females at 1,000 ppm (200 mg/kg/day, exceeding Category 2), eosinophilic changes in the respiratory epithelium of the nasal cavity were observed at or above 4,000 ppm (800 mg/kg/day, exceeding Category 2), and eosinophilic changes in the olfactory epithelium of the nasal cavity were observed at 16,000 ppm (3,200 mg/kg/day, exceeding Category 2) (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 1994)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 72-hour EC50 = 45.3 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2020). The classification result was changed from the previous classification by using new information.
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because sufficient data on rapid degradability were not obtained, and it was classified in Category 3 in acute toxicity. The classification result was changed from the previous classification by using new information.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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