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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	75-99-0
Chemical Name	2,2-Dichloropropionic acid; Dalapon
Substance ID	R02-B-038-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." Besides, sodium salt was targeted in the previous classification, but the titled substance was used this time.
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (GESTIS (Access on May 2020)).
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, there is information that it attacks aluminium, copper, and their alloys (ICSC (2003)).
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). (3) was deleted from the rationale because it was not described in the source literature. [Evidence Data] (1) LD50 for rats: females: 6,936 mg/kg, males: 7,126 mg/kg (HSDB (Access on May 2020)) (2) LD50 for rats: 7,000 mg/kg (MAK (DFG) (2004)) [Reference Data, etc.] (3) LD50 for rats: 700-1,000 mg/kg (GESTIS (Access on May 2020))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (ACGIH (7th, 2001), MAK (DFG) (2004), HSDB (Access on May 2020))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	[Rationale for the Classification] It was classified in Category 2 from (1), (2). The classification result was changed due to new data obtained. [Evidence Data] (1) This substance was irritating to the eye, skin, and respiratory tract (GESTIS (Access on May 2020)). (2) This substance was moderately irritating to the eye and skin (HSDB (Access on May 2020)). [Reference Data, etc.] (3) It was classified in Skin Irrit. 2 (H315) in EU-CLP classification (EU CLP classification (Access on May 2020)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) Direct contact with this substance could cause permanent eye damage (GESTIS (Access on May 2020)). [Reference Data, etc.] (2) This substance was irritating to the eye, skin, and respiratory tract (GESTIS (Access on May 2020)). (3) It was classified in Eye Dam. 1 (H318) in EU-CLP classification (EU CLP classification (Access on May 2020)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Besides, the data used as the rationale in the previous classification could not be confirmed in available information sources.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for in vitro, it is reported that the sodium salt of this substance was negative in a bacterial reverse mutation test (ACGIH (7th, 2001)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There is no available report targeted at humans. No carcinogenicity test result on this substance was obtained in experimental animals, but ACGIH classified this substance in A4 in (1) based on the test results for the sodium salt in (2) and because this substance was not genotoxic. Therefore, this substance was classified as "Not classified." [Evidence Data] (1) As for classification results by domestic and international organizations, ACGIH classified it in A4 (ACGIH (7th, 2001)). (2) In tests in which the sodium salt of this substance (CAS RN 127-20-8) was administered to dogs for 1 year and rats for 2 years, no tumor incidences were observed in either species (ACGIH (7th, 2001)).
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified. Although the information source for the previous classification could not be used, a new information source and the information on the sodium salt of this substance were used. As a result, the classification results were changed from the previous classification. [Evidence Data] (1) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, only a decrease in fetal body weight was observed, and no teratogenicity was observed even at doses exceeding the limit level (ACGIH (7th, 2001)). (2) In a three-generation test in which 150 mg/kg/day of sodium salt of this substance (CAS RN 127-20-8) was dosed by feeding, no reproductive effects were observed (ACGIH (7th, 2001)).
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3 (respiratory tract irritation). New information sources were used and the classification results were changed. [Evidence Data] (1) Acute exposures to vapors or aerosols of this substance (details were not provided) triggered weak to moderate irritations of the eyes, respiratory tract, and skin as well as the gastrointestinal tract in humans. Exposures to 2 to 7 ppm of this substance resulted in minimal irritations of the respiratory tract (GESTIS (Access on May 2020)). (2) The TLV-TWA (5 mg/m3) for this substance was set to minimize the potential of ocular and respiratory tract irritation (ACGIH (7th, 2001)). [Reference Data, etc.] (3) Accidental oral intake of this substance is expected to entail irritative effects or possibly corrosive effects and gastrointestinal disorders (vomiting, diarrhea) in humans (GESTIS (Access on May 2020)). (4) Common symptoms of poisoning are a feeling of lassitude, vomiting, diarrhea, slowing of pulse, loss of appetite, etc. (HSDB (Access on May 2020)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1) and (2) showing data from the studies using sodium salt of this substance, this substance was considered to be classified as "Not classified" in the oral route but there was no data available on the other administration routes. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) In a 97-day study of rats dosed with sodium salt of this substance (CAS RN 127-20-8) by feeding, at 115 mg/kg/day, an increase in kidney weight was observed in female rats, but no abnormalities were observed in other examinations including histopathological examinations (ACGIH (7th, 2001)) (2) In a two-year study of rats dosed with sodium salt of this substance (CAS RN 127-20-8) by feeding, at 50 mg/kg/day, an increase in relative kidney weight was observed, but no histopathological changes were observed (ACGIH (7th, 2001), IRIS (1988)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 96-hour LC50 = 5,500 mg/L for fish (Alburnus alburnus) (ECOTOX, 2020).
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not rapidly degradable (BIOWIN), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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