GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 72-20-8
Chemical Name 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8-dimethanonaphthalene; endrin
Substance ID R02-B-045-MHLW, MOE
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. It was classified as "Not classified."
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
7 Flammable solids Not classified
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on May 2020)).
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties, an epoxide, present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2761), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G.
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
10 Pyrophoric solids Not classified
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on May 2020)).
11 Self-heating substances and mixtures Not classified
-
-
- - It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on May 2020)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
14 Oxidizing solids Not classified (Not applicable)
-
-
- - The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified."
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16 Corrosive to metals Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid substances are not available. Besides, there is information that it mildly attacks metals (HSDB (Access on May 2020)).
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 1


Danger
H300 P301+P310
P264
P270
P321
P330
P405
P501
[Rationale for the Classification]
it was classified in Category 1 from (1) - (13).
Besides, the classification result was changed from the previous classification by reviewing information.

[Evidence Data]
(1) LD50 for rats: 3 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), GESTIS (Access on May 2020), HSDB (Access on May 2020))
(2) LD50 for rats: 4 mg/kg (EHC 130 (1992))
(3) LD50 for rats: females: 4.0 mg/kg, males: 8.9 mg/kg (EHC 130 (1992))
(4) LD50 for rats: 5.3 mg/kg (ACGIH (7th, 2001), HSDB (Access on May 2020))
(5) LD50 for rats: females: 5.3 mg/kg, males: 5.6 mg/kg (EHC 130 (1992))
(6) LD50 for rats: 5.3-43.4 mg/kg (ATSDR (2019))
(7) LD50 for rats: females: 7.3 mg/kg, males: 43.4 mg/kg (EHC 130 (1992))
(8) LD50 for rats: females: 7.5 mg/kg, males: 17.8 mg/kg (EHC 130 (1992))
(9) LD50 for rats: males: 9.0 mg/kg (EHC 130 (1992))
(10) LD50 for rats: females: 16.8 mg/kg, males: 28.8 mg/kg (EHC 130 (1992))
(11) LD50 for rats: 16.8-28.8 mg/kg (ATSDR (2019))
(12) LD50 for rats: males: 27 mg/kg (EHC 130 (1992))
(13) LD50 for rats: males: 40 mg/kg (EHC 130 (1992))
1 Acute toxicity (Dermal) Category 1


Danger
H310 P302+P352
P361+P364
P262
P264
P270
P280
P310
P321
P405
P501
[Rationale for the Classification]
It was classified in Category 1 from (1) - (6).

[Evidence Data]
(1) LD50 for rats: 5-20 mg/kg (EHC 130 (1992), MAK (DFG) vol.18 (2002), GESTIS (Access on May 2020))
(2) LD50 for rats: females: 5-10 mg/kg, males: 10-20 mg/kg (EHC 130 (1992))
(3) LD50 for rats: about 10 mg/kg (EHC 130 (1992))
(4) LD50 for rats: 12.5 mg/kg (EHC 130 (1992))
(5) LD50 for rats: females: 15 mg/kg, males: 18 mg/kg (ATSDR (2019), EHC 130 (1992), HSDB (Access on May 2020))
(6) LD50 for rats: 18 mg/kg (EHC 130 (1992), Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002))

[Reference Data, etc.]
(7) LD50 for rabbits: 60 mg/kg (GESTIS (Access on May 2020))
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - [Rationale for the Classification]
From (1), there were data that 3-5 out of 10 animals died in a test by 1-hour exposure of rats to dust at a concentration of 2 mg/L of air (converted 4-hour equivalent value: 0.5 mg/L), but there were no LC50 value data, and the category could not be determined. Therefore. it was classified as "Classification not possible."

[Reference Data, etc.]
(1) In a test by 1-hour exposure of rats to dust at a concentration of 2 mg/L of air (converted 4-hour equivalent value: 0.5 mg/L), 3-5 out of 10 animals died (EHC 130 (1992), MAK (DFG) vol.18 (2002)).
2 Skin corrosion/irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1), (2).

[Evidence Data]
(1) No irritation was seen in an experiment in which the powders of this substance (75 or 150 mg/kg) were applied to rabbits for 2 hours/day, 5 days/week for 14 weeks, and no effects in the skin were observed in an experiment in which the powders of this substance (250 mg/kg) were applied to the rabbit skin for 24 hours (EHC 130 (1992), MAK (DFG) vol.18 (2002), GESTIS (Access on May 2020)).
(2) This substance does not irritate or sensitize the skin (GESTIS (Access on May 2020)).

[Reference Data, etc.]
(3) Despite its extensive use for many years with the associated possibilities of contact with eyes and skin, no local irritation or damage has been reported (GESTIS (Access on May 2020)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - [Rationale for the Classification]
There is a description of (1), but it was classified as "Classification not possible" due to lack of data.

[Reference Data, etc.]
(1) Despite extensive use of this substance for many years with the associated possibilities of contact with eyes and skin, no local irritation or damage has been reported (GESTIS (Access on May 2020)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
There is a description of (1), but it was classified as "Classification not possible" due to lack of data.

[Reference Data, etc.]
(1) This substance does not irritate or sensitize the skin (GESTIS (Access on May 2020)).
5 Germ cell mutagenicity Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1) - (3).

[Evidence Data]
(1) As for in vivo, it was reported to be negative in a dominant lethal test with mice. On the other hand, positive results in DNA damage tests using mice and rats were reported, but these effects were considered to be caused by oxidative stress induced by high levels of this substance in the tissues (ATSDR (2019), MAK (DFG) vol.18 (2002), EHC 130 (1992)).
(2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test, a chromosomal aberration test in cultured mammalian cells, a gene mutation test in cultured mammalian cells, a sister chromatid exchange test with human lymphocytes, and unscheduled DNA synthesis tests using human lung fibroblasts and rat hepatocytes. And it was reported to be positive and negative in DNA damage tests using cultured rat cells (ATSDR (2019), EHC 130 (1992), CEBS (Access on May 2020)).
(3) It is reported that no chromosomal aberrations in peripheral blood lymphocytes from workers exposed to this substance (MAK (DFG) vol.18 (2002), EHC 130 (1992)).
6 Carcinogenicity Not classified
-
-
- - [Rationale for the Classification]
There was no available report targeted to humans. It was classified as "Not classified" from (1), (2).

[Evidence Data]
(1) As for classification results by domestic and international organizations, It was classified in Group 3 by IARC (IARC Sup7 (1987)), A4 by ACGIH (ACGIH (7th, 2001)), and D (not classifiable as to carcinogenicity for humans) by EPA (IRIS (1989)).
(2) In carcinogenicity tests by 80-week diet administration of this substance to male and female rats and mice, no treatment-related increases in tumor incidences were observed in either species, and it was concluded that this substance was not carcinogenic in rats and mice (NTP TR12 (1979)).
7 Reproductive toxicity Not classified
-
-
- - [Rationale for the Classification]
Based on (1) to (5), it was classified as "Not classified."

[Evidence Data]
(1) In a three-generation reproduction toxicity test with rats dosed by feeding, no reproductive effects were observed (EHC 130 (1992)).
(2) In a reproduction toxicity study with mice dosed by feeding, a significant increase in parental mortality (32%) and a decrease in litter size were observed, but fertility, fecundity, and the number of litters produced per pair were not affected (EHC 130 (1992)).
(3) In a developmental toxicity study with female rats dosed by gavage on days 7 to 20 of gestation, even at doses at which maternal toxicity effects (reduced body weight gain) were observed, no effect was observed in fetuses (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002), EHC 130 (1992)).
(4) In a developmental toxicity study with female mice by gavage on days 7 to 17 of gestation, even at doses at which maternal toxicity effects (reduced body weight gain, an increase in liver weight, death) were observed, no teratogenicity or embryonic lethality was observed (EHC 130 (1992)).
(5) In a developmental toxicity study with female hamsters by gavage on days 4 to 13 of gestation, even at a dose at which maternal toxicity effects (reduced body weight gain) were observed, no teratogenicity was observed in fetuses, although delayed ossification was observed (EHC 130 (1992)).

[Reference Data, etc.]
(6) In a developmental toxicity study with female hamsters dosed by gavage with a single oral dose at 5 mg/kg (half of the LD50 value) on day 7, 8 or 9 of gestation, after administration on day 8 of gestation, a high incidence of congenital abnormalities was observed, and open eye, webbed foot, cleft palate, and fused ribs increased. On all dose days, cleft palate and fused ribs increased to the same degree (EHC 130 (1992)). The EHC 130 (1992) indicated that congenital abnormalities, which were observed in this study, could not be confirmed in other studies.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
Based on (1) to (7), it was classified in Category 1 (nervous system, liver, kidney).

[Evidence Data]
(1) Acute human poisoning by this substance caused central nervous system toxicity effects such as jerking of the arms and legs, twitching of facial muscles, tonic and clonic contractions, convulsions and sudden collapse, and death. In workers who manufactured this substance, numerous cases of convulsions following acute, high-level exposure were reported (ATSDR (2019)).
(2) In mild cases of poisoning, dizziness, weakness of the legs, abdominal discomfort, nausea, and vomiting were reported. Severe poisoning was manifested by sudden epileptiform fits with frothing at the mouth, facial congestion, and violent convulsive movements of the limbs, sometimes leading to dislocation of the shoulder or other injuries (EHC 130 (1992)).
(3) In humans, the severe neurotoxic effects of this substance rapidly resulted in symptoms such as nausea, vomiting, dizziness, stomachache, headache, sudden unconsciousness, convulsions, and depression of the central nervous system (MAK (DFG) vol.18 (2002)).
(4) In the past, there were cases of intoxication as a result of repeated and accidental ingestion of contaminated food and after dermal exposure. The main symptoms reported were nausea, vomiting, dizziness, stomachache, headache, sudden unconsciousness, seizures, and depression of the central nervous system, which began 0.5 to 10 hours after uptake of this substance (MAK (DFG) vol.18 (2002)).
(5) In a case of an accidental exposure at a plant in the Netherlands, convulsions due to intoxication were observed but they regressed completely in a short time (Environmental Risk Assessment for Chemical Substances Vol. 1 (Ministry of the Environment, 2002)).
(6) As a result of single oral administration (4 mg/kg, within the range for Category 1) using rats, mice, hamsters, and guinea pigs, apoptosis and focal necrosis (changes in the cell nucleus, cytoplasm and membrane fragmentation), inflammatory reactions (leukocyte infiltration and congestion), interstitial edema, hyperplasia of Kupffer's cells, etc. in the liver were observed in all species. In rats, fat accumulation and bile stasis were also observed. In the kidney, cell necrosis, cloudy swelling, accumulation of hyaline droplets in the renal tubules (only rats and hamsters), interstitial edema, narrowing of the lumen, and infiltration of inflammatory cells (only rats and mice) were observed (MAK (DFG) vol.18 (2002), ATSDR (2019)).
(7) In single oral, dermal, and inhalation toxicity tests with experimental animals, increased liver weight, altered liver serum enzymes, diffuse degenerative lesions, necrosis, vacuolation, fatty degeneration, and lipid peroxidation were observed (ATSDR (2019)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver)


Danger
H372 P260
P264
P270
P314
P501
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1 (nervous system, liver).

[Evidence Data]
(1) In a two-year feeding study with rats, reduced body weight gain during the first 40 weeks and an increase in relative liver weight were observed at or above 5 ppm (0.25 mg/kg/day, within the range for Category 1); an increase in mortality, diffuse degenerative changes in the brain, liver, kidney, and adrenal gland in animals that died, and an increase in relative liver weight in females were observed at or above 25 ppm (1.25 mg/kg/day, within the range for Category 1); and over-sensitivity to external stimuli, epileptic seizures, and degenerative changes in the liver in surviving animals were observed at or above 50 ppm (2.5 mg/kg/day, within the range for Category 1) (MAK (DFG) vol.18 (2002), JMPR (1965), ATSDR (2019)).
(2) In a two-year feeding study with dogs, convulsions and hepatic cell vacuolation were observed in females at or above 0.05 mg/kg/day (within the range for Category 1) and in males at 0.1 mg/kg/day (within the range for Category 1) (ATSDR (2019)).

[Reference Data, etc.]
(3) It was suggested that the most sensitive effects in experimental animals were neurological effects (such as changes in activities and convulsions) and hepatotoxicity. Diffuse disorders of organs (lung, heart, kidney, endocrine gland), effects on body weight, etc. were generally observed only at the lethal dose (ATSDR (2019)).
(4) It was stated that, in addition to effects on the central nervous system, other major symptoms of acute and chronic toxicity were damages of the liver and kidney, probably as a result of oxidative stress (MAK (DFG) vol.18 (2002)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 96-hour LC50 = 0.000037 mg/L for crustacea (Penaeus duorarum) (EHC 130, 1992).
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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