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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	13593-03-8
Chemical Name	O,O-Diethyl O-2-quinoxalinyl phosphorothioate; Quinalphos
Substance ID	R02-B-048-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is information that it is combustible (GESTIS (Access on May 2020)).
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (P-O) present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2783), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G.
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Not classified	- -	-	-	Because it is classified in Division 6.1 in UNRTDG (UN2783), and it does not correspond to pyrophoric substances, hazards of the highest precedence, it was classified as "Not classified."
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 17.8 ppm (22-23 deg C, Japan Crop Protection Association (1991)).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] It was classified in Category 3 from (1). [Evidence Data] (1) LD50 for rats: females: 51 mg/kg, males: 56 mg/kg (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	[Rationale for the Classification] It was classified in Category 3 from (1), (2). [Evidence Data] (1) LD50 for rats: 300 mg/kg (GESTIS (Access on May 2020)) (2) LD50 for rats: females: 850 mg/kg, males: 940 mg/kg (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] It was classified in Category 2 from (1). Besides, because an exposure concentration was higher than the saturated vapor pressure concentration (4.2E-005 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) LC50 for rats (4 hours): 0.45 mg/L (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)) (2) Vapor pressure of this substance: 2.6E-006 mmHg (20 deg C) (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)) (converted value for the saturated vapor pressure concentration: 4.2E-005 mg/L)
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" (Category 3 in UN GHS classification) from (1). [Evidence Data] (1) In a skin irritation test by 24-hour occlusive application of this substance (0.5 mL) to rabbits, no skin reactions were seen except for very slight erythema observed in 1/3 animals at 24 hours after the application (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In an eye irritation test in which this substance (0.1 mL) was applied to the rabbit eye, 1/6 animals died at 21 hours after the application, but no irritation reactions were seen in the other five animals. Besides, the dead animal did not show signs of organophosphorus poisoning (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In a skin sensitization test with guinea pigs (20 animals) (maximization test), 5/20 animals died after the application of the first patch, but the remaining 15 animals showed only skin reactions in part of the animals that were similar to those in the control group after a challenge, and it was judged as negative for sensitization (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)).
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells and a chromosomal aberration test with rat bone marrow cells (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)). (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test (same as the above).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. It was classified as "Not classified" from (1), (2). [Evidence Data] (1) In a combined chronic toxicity/carcinogenicity test by 2-year diet administration of this substance to male and female rats, no significant increase in tumor incidences was observed (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)). (2) In a carcinogenicity test by 18-month diet administration of this substance to male and female mice, no significant increase in tumor incidences was observed (Japanese Journal of Pesticide Science Vol. 16 No. 2 (Pesticide Science Society of Japan, 1991)).
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." [Evidence Data] (1) In a three-generation reproduction toxicity study with rats dosed by feeding, no effects on fertility or teratogenicity were observed (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, at a dose at which maternal toxicity effects (tremor, a decrease in body weight) were observed, no effect was observed in fetuses (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (3) It was reported that in a developmental toxicity study with female rabbits dosed by gavage on days 6 to 18 of gestation, at a dose at which maternal toxicity (no description) was observed, only effects on fetuses, which were considered to be due to maternal toxicity, were observed and there was no teratogenicity (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (nervous system). [Evidence Data] (1) After a single oral dose of up to 30 mg/kg was given to mice, behaviors and symptoms were observed. As a result, dose-dependent neurologic symptoms, such as tremors and tonic convulsions, were observed, and 1/4 mice in the group dosed at 30 mg/kg died about 30 minutes after administration (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (2) In single exposure tests with rats, the LD50 value was within the range for Category 1 in each of the oral, dermal, and inhalation routes (Same as above). [Reference Data, etc.] (3) Organophosphorus pesticides, such as this substance, are absorbed by all routes, including inhalation, ingestion, and dermal absorption. The toxicological effects of the organophosphorus pesticides are due to the inhibition of acetylcholinesterase in the nervous system, resulting in respiratory, myocardial, and neuromuscular transmission impairment (IPCS PIM G001 (1998)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1) to (5), inhibition of red blood cell, plasma, and brain cholinesterase (ChE) activities was observed at doses within the range for Category 1, and therefore, it was classified in Category 1 (nervous system). The inhibition of ChE activities was adopted as the rationale for the classification and the classification results were changed from the previous classification. [Evidence Data] (1) In a 13-week dietary administration study with rats, an increase in relative liver weight and inhibition of brain ChE activity were observed at 10 ppm (0.5 mg/kg/day, within the range for Category 1) (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (2) In a 13-week dietary administration study with rats, inhibition of red blood cell and plasma ChE activities was observed at or above 12 ppm (0.6 mg/kg/day, within the range for Category 1), and inhibition of brain ChE activity was observed at 48 ppm (2.4 mg/kg/day, within the range for Category 1) (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (3) In a two-year dietary administration study with rats, inhibition of red blood cell and plasma ChE activities was observed at 10 ppm (later, increased to 20 ppm) (0.5 to 1.0 mg/kg/day, within the range for Category 1) (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (4) In an 18-month dietary administration study with mice, inhibition of plasma ChE activities was observed at 5 ppm (0.75 mg/kg/day, within the range for Category 1) (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)). (5) In a two-year dietary administration study with dogs, inhibition of plasma ChE activities was observed at 2 ppm (0.05 mg/kg/day, within the range for Category 1) (Japanese Journal of Pesticide Science Vol. 16, No. 2 (Pesticide Science Society of Japan, 1991)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.00021 mg/L for crustacea (Daphnia magna) (ECOTOX, 2020).
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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