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GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	77458-01-6
Chemical Name	O-1-(4-Chlorophenyl)-4-pyrazolyl O-ethyl S-propyl phosphorothioate; Pyraclofos
Substance ID	R02-B-052-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Classification not possible	- -	-	-	No data available.
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (P-O) present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN3018), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G.
9	Pyrophoric liquids	Not classified	- -	-	-	Because it is classified in Division 6.1 in UNRTDG (UN3018), and it does not correspond to pyrophoric substances, hazards of the highest precedence, it was classified as "Not classified."
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of 33 mg/L (20 deg C) (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)).
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition). It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] It was classified in Category 3 from (1). [Evidence Data] (1) LD50 for rats: 237 mg/kg (Food sanitation research vol. 46, No. 19 (Japan Crop Protection Association, 1996), Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). Besides, the classification result was changed from the previous classification due to the use of a new information source. [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	[Rationale for the Classification] It was classified in Category 4 from (1). Besides, the classification result was changed from the previous classification due to the use of a new information source. Because an exposure concentration was higher than the saturated vapor pressure concentration (2.3E-007 mg/L), a reference value in the unit of mg/L was applied as mist. [Evidence Data] (1) LC50 for rats (4 hours): females: 1.46 mg/L, males: 1.69 mg/L (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)) (2) Vapor pressure of this substance: 1.2E-008 mmHg (20 deg C) (Japan Crop Protection Association (1990)) (converted value for the saturated vapor pressure concentration: 2.3E-007 mg/L)
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) In a skin irritation test by 4-hour application of this substance (0.5 mL) to the rabbit skin, no irritation was observed (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) In an eye irritation test in which this substance (0.1 mL) was applied to rabbits, no irritation was observed (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) In a skin sensitization test (Buehler test) in which this substance (undiluted) was applied to guinea pigs, it was reported to be negative (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) As for in vitro, it was reported to be negative in a bacterial reverse mutation test and chromosomal aberration test using cultured mammalian cells (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. It was classified as "Not classified" from (1). The classification result was changed due to the use of a new information source. [Evidence Data] (1) In combined repeated dose toxicity/carcinogenicity tests by 2-year diet administration of this substance to male and female rats and mice, no carcinogenicity was observed in either species (Japanese Journal of Pesticide Science vol. 15 (Pesticide Science Society of Japan, 1990)).
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." A new information source was used and the classification results were changed from the previous classification. [Evidence Data] (1) In a two-generation reproduction toxicity study with rats dosed by feeding, reduced body weight gain and a decrease in food consumption were observed, but no effect on fertility was observed. A decrease in survival rate of offspring was observed at the maximum dose level, but it was considered to be due to abnormal behaviors of dams because deaths of offspring were observed mainly during the lactation period, there was no milk in the stomach of dead offspring, and cannibalism occurred frequently (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, no effect was observed in fetuses even at a dose at which maternal toxicity (respiratory rale, hypoactivity, tremor, excessive salivation, lacrimation, discharges around the eye, soiled fur in the perineal area, reduced body weight gain) was observed (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)). (3) In a developmental toxicity study with female rabbits dosed by gavage on days 6 to 18 of gestation, no effect was observed in fetuses even at a dose at which maternal toxicity (decreases in plasma and erythrocyte ChE activity, diarrhea, lying on side shortly after administration, reduced body weight gain, a decrease in food consumption) was observed (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (nervous system). A new information source was used and the classification results were changed from the previous classification. [Evidence Data] (1) As a result of oral administration of this substance (237 mg/kg or lower dose level) to rats and mice, a decrease in locomotor activity, gait abnormality, diarrhea, lacrimation, salivation, dyspnea, etc. were observed, but all the symptoms disappeared within 14 days at most (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)). (2) This substance was an organophosphorus pesticide, and in subacute and chronic toxicity studies, cholinesterase inhibition in plasma, erythrocyte, and brain was observed (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, blood system), Category 2 (gastrointestinal tract)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1) to (5), it was classified in Category 1 (nervous system, blood system) and Category 2 (gastrointestinal tract). In a chronic toxicity study with rats in (3), findings in the testis, uterus, liver, and thyroid were reported, but as for the liver, it was stated that these changes were considered to be due to a low nutritional state, and no effects on these organs were reported in a chronic toxicity study with rats in (4), and therefore, they were not considered to be target organs. Examination was conducted based on the information from the new source, and the classification results were changed from the previous classification. [Evidence Data] (1) As a result of three-month oral administration to rats by feeding, at or above 10 ppm (converted guidance value: 1 mg/kg/day, within the range for Category 1), decreases in plasma and erythrocyte cholinesterase (ChE) activity were observed in males and females; and at or above 1,000 ppm (converted guidance value: 100 mg/kg/day, within the range for Category 2), decreases in hematocrit value, hemoglobin concentration, and erythrocyte count, a decrease in brain ChE activity, vacuolation of the mucosa epithelial cells of the jejunum/ileum, edema of the lamina propria, slight small round cell infiltration, and catarrhal enteritis with adhesion of mucosa-like substances containing cell breakage objects on the mucosal surface were observed in males and females, and whitening of the adrenal gland was observed in females (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)). (2) As a result of three-month oral administration to mice by feeding, at or above 1 ppm (converted guidance value: 0.15 mg/kg/day, within the range for Category 1), a decrease in plasma ChE activity was observed; and at 200 ppm (converted guidance value: 30 mg/kg/day, within the range for Category 2), decreases in erythrocyte count, hemoglobin concentration, hematocrit value, and MCV, and decreases in erythrocyte and brain ChE activity were observed (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990)). (3) As a result of 24-month oral administration to rats by feeding, at or above 10 ppm (converted guidance value: 0.5 mg/kg/day, within the range for Category 1), atrophy of the seminiferous tubules of the testis, lumen dilation of the uterine horn, and a decrease in erythrocyte ChE activity were observed; at or above 100 ppm (converted guidance value: 5 mg/kg/day, within the range for Category 1), reduced body weight gain, fatty degeneration of the hepatocytes (it was stated that the change was considered to be due to a low nutritional state), enlarged follicles of the thyroid, a decrease in erythrocyte count, etc. were observed; and at 300 ppm (converted guidance value: 15 mg/kg/day, within the range for Category 2), a decrease in brain ChE activities, and decreases in plasma and erythrocyte ChE activity were observed (Japanese Journal of Pesticide Science Vol. 15 (Pesticide Science Society of Japan, 1990), Food Sanitation Research vol. 46, No. 19 (Japan Crop Protection Association, 1996)). (4) As a result of 24-month oral administration to mice by feeding, at 70 ppm (converted guidance value: 1.05 mg/kg/day, within the range for Category 1), reduced body weight gain and a decrease in erythrocyte ChE activity were observed (Same as above). (5) As a result of one-year oral administration to dogs, at or above 3 mg/kg (within the range for Category 1), increased pigmentation of the spleen, decreases in erythrocyte count, hemoglobin concentration, and hematocrit value, an increase in ALT activity, a decrease in erythrocyte ChE activity, etc. were observed; and at 15 mg/kg (within the range for Category 2), increased vacuolation of the adrenal cortex, an increase in serum potassium, an increase in ALP activity, and a decrease in brain ChE activity were observed (Food Sanitation Research vol. 46, No. 19 (Japan Crop Protection Association, 1996)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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