GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 23135-22-0
Chemical Name N',N'-dimethylcarbamoyl(methylthio)methylenamine N-methylcarbamate; Oxamyl
Substance ID R02-B-097-MHLW, MOE
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified
-
-
- - There is a chemical group associated with explosive properties (N-O bond) present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2757), and it does not correspond to explosives, hazards of the highest precedence, it was classified as "Not classified."
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. It was classified as "Not classified."
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with explosive properties (N-O bond) present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2757), and it does not correspond to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G.
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16 Corrosive to metals Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives Classification not possible
-
-
- - There is a chemical group associated with explosive properties (N-O bond) present in the molecule, but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 1


Danger
H300 P301+P310
P264
P270
P321
P330
P405
P501
[Rationale for the Classification]
It was classified in Category 1 from (1) - (4).
Besides, the classification result was changed from the previous classification by using new information sources.

[Evidence Data]
(1) LD50 for rats: 2.5 mg/kg (JMPR Report (2017), GESTIS (Access on June 2020))
(2) LD50 for rats: females: 2.5 mg/kg, males: 3.1 mg/kg (EPA Pesticides RED (2007), HSDB (Access on June 2020))
(3) LD50 for rats: 2.5-3.1 mg/kg (US AEGL (2009))
(4) LD50 for rats: 5.4 mg/kg (EHC 64 (1986), HSDB (Access on June 2020))
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
[Rationale for the Classification]
It was classified in Category 3 from (1) - (5).
Besides, the classification result was changed from the previous classification by using new information sources.

[Evidence Data]
(1) LD50 for rabbits: 710 mg/kg (EHC 64 (1986))
(2) LD50 for rabbits: 740 mg/kg (GESTIS (Access on June 2020))
(3) LD50 for rabbits: > 2,000 mg/kg (JMPR Report (2017), US AEGL (2009))
(4) LD50 for rabbits: 2,960 mg/kg (HSDB (Access on June 2020))
(5) LD50 for rats: > 1,200 mg/kg (HSDB (Access on June 2020))
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
[Rationale for the Classification]
It was classified in Category 2 from (1) - (3).
Besides, because exposure concentrations were higher than the saturated vapor pressure concentration (0.0027 mg/L), a reference value in the unit of mg/L was applied as dust.

[Evidence Data]
(1) LC50 for rats (4 hours): 0.05-0.065 mg/L (JMPR (2002))
(2) LC50 for rats (4 hours): 0.056 mg/L (US AEGL (2009))
(3) LC50 for rats (4 hours): males: 0.064 mg/L (US AEGL (2009), HSDB (Access on June 2020))
(4) Vapor pressure of this substance: 2.3E-004 mmHg (20-25 deg C) (HSDB (Access on May 2020)) (converted value for the saturated vapor pressure concentration: 0.0027 mg/L)
2 Skin corrosion/irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1), (2).

[Evidence Data]
(1) This substance was not irritating to the eyes or skin of rabbits (JMPR Report (2017), US AEGL (2009)).
(2) It is reported that in a skin irritation test with rabbits according to EPA OPPTS 870.2500 on this substance, it was classified in toxicity Category IV (at 72 hours after application, slight irritation (no irritation or slight erythema)) (EPA Pesticides RED (2007)).
3 Serious eye damage/eye irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from results from a GLP-compliant test in (1).

[Evidence Data]
(1) This substance was reported to be not irritating in an eye irritation test with rabbits according to OPPTS 870.2400 and OECD 405 (GLP-compliant) (JMPR Report (2017), US AEGL (2009)).

[Reference Data, etc.]
(2) It is reported that in an eye irritation test with rabbits according to EPA OPPTS 870.2400 (unpublished data), this substance was classified in toxicity Category III (there were corneal effects, or other symptoms disappeared within 7 days after application) (EPA Pesticides RED (2007)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1), (2).

[Evidence Data]
(1) This substance did not sensitize the skin of guinea pigs (JMPR Report (2017), US AEGL (2009)).
(2) It was not a sensitizer in a skin sensitization test with guinea pigs according to EPA OPPTS 870.2600 (EPA Pesticides RED (2007)).
5 Germ cell mutagenicity Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified."

[Evidence Data]
(1) As for in vitro, it was reported to be negative in a bacterial reverse mutation test, a chromosomal aberration test, a gene mutation test, and an unscheduled DNA synthesis test using cultured mammalian cells (JMPR (2002), US AEGL (2009)).
6 Carcinogenicity Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1), (2).

[Evidence Data]
(1) As for classification results by domestic and international organizations, EPA classified it in E (Evidence of Non-Carcinogenicity for Humans) (EPA Annual Cancer Report 2019 (Access on September 2020): classified in 1996).
(2) In carcinogenicity tests by 2-year diet administration of this substance to rats and mice, no treatment-related increases in tumor incidence were observed in either species, and it was concluded that this substance was not carcinogenic in rats or mice (JMPR Report (2017)).
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
[Rationale for the Classification]
Based on (1) and (2), effects on offspring and fetuses were observed at a dose of maternal toxicity. Since the degree of effects was unknown, it was classified in Category 2 according to the GHS Classification Guidance for the Japanese Government. New information sources were used and the classification results were changed from the previous classification.

[Evidence Data]
(1) In a two-generation reproduction toxicity test with rats dosed by feeding, a decrease in body weight, reduced body weight gain, a decrease in food consumption, etc. were observed in dams at or above 75 ppm; and in fetuses, a decrease in body weight of offspring was observed at or above 75 ppm, and a decrease in litter size was observed at 150 ppm (JMPR (2002)).
(2) In a developmental toxicity study with female rabbits dosed by gavage on days 6 to 19 of gestation, reduced body weight gain was observed in dams at or above 2 mg/kg/day, and a decrease in fetal viability and complete embryo resorption (2 dams) were observed in fetuses at 4 mg/kg/day (JMPR (2002)).

[Reference Data, etc.]
(3) In a developmental toxicity study with female rats dosed by gavage on days 7 to 16 of gestation, reduced body weight gain at or above 0.5 mg/kg/day, a decrease in food consumption at or above 0.8 mg/kg/day, and clinical signs of cholinesterase activity inhibition (tremors, salivation, wet perineum, diarrhea, etc.) at 1.5 mg/kg/day were observed in dams, and a decrease in fetal weight was observed in fetuses at or above 0.5 mg/kg/day (JMPR (2002)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
[Rationale for the Classification]
There was no report on acute exposure effects of this substance in humans. Based on (1) and (2), it was classified in Category 1 (nervous system). New information sources were used and the classification results were changed from the previous classification.

[Evidence Data]
(1) In a 4-hour acute inhalation exposure test with male rats (0.036 mg/L, within the range for Category 1), intense salivation, facial fasciculations, red discharge around the nose, lacrimation, exophthalmos, difficulty in breathing, and gasping were observed (US AEGL (2009)).
(2) In an acute inhalation exposure test with rats (the minimum dose at which effects were observed was not described, and it was assumed that effects were observed at least around the LC50 value (0.056 mg/L, within the range for Category 1)), red nasal discharge, gasping, and salivation were observed, and after the exposure, lethargy, a decrease in muscle tone, tremors, spasms, fasciculations, abnormal posture, abnormal gait, ataxia, etc. were observed (US AEGL (2009)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system)


Danger
H372 P260
P264
P270
P314
P501
[Rationale for the Classification]
There was no report on repeated exposure to this substance in humans. Based on (1) and (2), effects on the nervous system at doses of Category 1 were observed in experimental animals. Therefore, it was classified in Category 1 (nervous system). As a result of reviewing the information, the classification results were changed from the previous classification.

[Evidence Data]
(1) It was reported that, in a 90-day test with rats dosed by feeding, decreases in brain, plasma, and erythrocyte cholinesterase (ChE) activity inhibition, and impaired performance based on the criteria of the Functional Observational Battery (FOB) items were observed at 250 ppm (males/females: 14.9/19.9 mg/kg/day, within the range for Category 2 in both sexes) (US AEGL (2009)).
(2) It was reported that, in a 29-day test with rats dosed by feeding, at or above 100 ppm (converted guidance value: 5 mg/kg/day, within the range for Category 1), a decrease in plasma ChE activity was observed, and in addition, decreases in erythrocyte ChE activity in males and brain ChE activity in females were also observed (HSDB (Access on June 2020)).

[Reference Data, etc.]
(3) The clinical picture of poisoning by carbamate pesticides, including this substance, resulted from the accumulation of acetylcholine at nerve endings, and exhibited muscarinic, nicotinic, and central nervous system manifestations. Mild poisoning might include muscarinic and nicotinic signs only, but severe cases might include respiratory failure and pulmonary edema by the central nervous system manifestations (HSDB (Access on June 2020)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 48-hour EC50 = 0.321 mg/L for crustacea (Daphnia magna) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2011).
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 because it is not rapidly degradable (BIOWIN) and 28-day NOEC = 0.0189 mg/L for crustacea (Americamysis bahia) (EPA OPP Pesticide Ecotoxicity Database, 2020).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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