NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	460-19-5
Chemical Name	Oxalonitrile; Dicyan; Cyanogen
Substance ID	R02-B-099-MHLW, MOE
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	It was classified in Category 1 from explosion limits of 6.6-32 vol% (NFPA (14th, 2010)). Besides, it is classified in Division 2.3, Subsidiary Risk 2.1 in UNRTDG (UN1026).
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified	- -	-	-	It is classified in Division 2.3, Subsidiary Risk 2.1 in UNRTDG (UN1026), not Division 5.1, including Subsidiary Risk. Therefore, it was classified as "Not classified."
5	Gases under pressure	Low pressure liquefied gas	Warning	-	-	It was classified as low-pressure liquefied gases from a critical temperature of 128.3 deg C (HSDB (Access on June 2020)).
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to gas substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) LC50 for rats (1 hour): > 250 ppm - < 400 ppm (converted 4-hour equivalent value: > 125 ppm - < 200 ppm) (US AEGL (2014)) (2) LC50 for rats (1 hour): 350 ppm (converted 4-hour equivalent value: 175 ppm) (ACGIH (7th, 2016), Patty (6th, 2012))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified."
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] There was a description of (1), but the classification was not possible due to lack of data. [Reference Data, etc.] (1) It is reported that in a test by whole-body exposure of rabbits equivalent to EU Method B.4 (Acute Toxicity: Dermal Irritation/Corrosion), there was no irritation (REACH registration dossier (Access on September 2020)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) This substance caused eye irritation at 16 ppm in humans (ACGIH (7th, 2016), ATSDR (2006), US AEGL (2014), GESTIS (Access on June 2020), HSDB (Access on June 2020), REACH registration dossier (Access on September 2020)). (2) Effects of this substance on the eye included conjunctival hyperemia, mild chemosis, lacrimation, photophobia, and tingling sensation (CICAD 61 (2004)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Only EPA's classification result in (1) was obtained, and it was classified as "Classification not possible." [Evidence Data] (1) As for classification results by domestic and international organizations, EPA classified it in I (Inadequate information to assess the carcinogenic potential) (IRIS Tox Review (2010)).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (narcotic effects, respiratory tract irritation)	Danger Warning	H370 H336 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system), and Category 3 (narcotic effects, respiratory tract irritation). [Evidence Data] (1) In humans, irritations of the eyes and nose were observed in volunteers who were exposed to this substance at 16 ppm for 6 or 8 minutes, and the irritations lasted for several minutes after the exposure was stopped. These irritations were not observed in a 6-minute exposure at 8 ppm (ACGIH (7th, 2016), US AEGL (2014), ATSDR (2006)). (2) As a result of a 7.5 to 120-minute exposure of rats to this substance at 250 ppm (the converted 4-hour equivalent value of a 120-minute exposure was 85 ppm (within the range for Category 1)), eye irritation, asphyxia, and effects on the central nervous system (restless and panic movements, poor coordination, tremor, lethargy, etc.) were observed (ATSDR (2006)). [Reference Data, etc.] (3) The target organs of acute cyanide exposure were the central nervous system, respiratory system, and cardiovascular system. Exposure to high levels of cyanide led to rapid death (ATSDR (2006)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification was not possible due to lack of data. As a result of reviewing the information, the classification result was changed from the previous classification. [Reference Data, etc.] (1) It was reported that, in a 6-month inhalation exposure test with rats, no effect was observed at doses up to 25 ppm (gas, 0.0532 mg/L, within the range for Category 1) (ACGIH (7th, 2016), CICAD 61 (2004), IRIS Tox Review (2010), US AEGL (2014)). (2) In a 6-month inhalation exposure test with monkeys, it was reported that only a decrease in total lung moisture content at or above 11 ppm (gas, 0.0234 mg/L, within the range for Category 1) and transient behavioral changes (the details were not known) at 25 ppm (gas, 0.0532 mg/L, within the range for Category 1) were observed (Same as above).
10	Aspiration hazard	Not classified	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour ErC50 = 0.12 mg/L for algae (Desmodesmus subspicatus) (REACH registration dossier, 2020). Besides, this substance rapidly forms hydrogen cyanide (CAS RN 74-90-8) by hydrolysis. When hydrogen cyanide is in water, undissociated hydrogen cyanide and cyanide ion are in equilibrium, and 93% or more exists as undissociated form at pH < 8 (Initial Risk Assessment (NITE, CERI, NEDO, 2008), inorganic cyanides), but reliable acute toxicity data were not obtained. The classification result was changed from the previous classification by using new information.
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it was classified in Category 1 in acute toxicity. Besides, this substance rapidly forms hydrogen cyanide (CAS RN 74-90-8) by hydrolysis. When hydrogen cyanide is in water, undissociated hydrogen cyanide and cyanide ion are in equilibrium, and 93% or more exists as undissociated form at pH < 8 (Initial Risk Assessment (NITE, CERI, NEDO, 2008), inorganic cyanides), but reliable toxicity data were not obtained. The classification result was changed from the previous classification by using new information.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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