GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 25134-01-4
Chemical Name Polymer of 2,6-dimethylphenol
Substance ID R02-B-106-MHLW
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2017  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. It was classified as "Not classified."
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
14 Oxidizing solids Not classified (Not applicable)
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified."
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16 Corrosive to metals Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1).

[Evidence Data]
(1) LD50 for rats: > 5,000 mg/kg (Patty (6th, 2012))
1 Acute toxicity (Dermal) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
Rats were exposed to concentrations that would likely occur in workplace situations for 6 hours, but no deaths or signs of toxicity were noted. Signs of eye and nasal irritation were observed but disappeared shortly after the animals were removed from the exposure chamber. No anomalies were found at gross necropsy (Patty (6th, 2012)).
2 Skin corrosion/irritation Not classified
-
-
- - [Rationale for the Classification]
It was classified as "Not classified" from (1). The previous classification was "Classification not possible" by referring to the same evidence data, but it was judged that it could be used as the evidence data for classification from experiment conditions (applied amount and application time).

[Evidence Data]
(1) In a skin irritation test by 4-hour application of this substance (500 mg) to rabbits, no irritation was seen (Patty (6th, 2012)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - [Rationale for the Classification]
There were data of (1), but the classification was not possible. The previous classification was Category 2B by using the same data as the evidence data, but the classification was not possible because detailed information such as the number of animals and scores was lacking.

[Reference Data, etc.]
(1) It is reported that in an eye irritation test with rabbits on this substance, within 1 hour after application, redness of the conjunctivae and chemosis were observed but resolved by 48 hours, and it produced mild and transient irritation (Patty (6th, 2012)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
There were data of (1), but details of test methods were unknown, and it was classified as "Classification not possible" due to lack of data.

[Reference Data, etc.]
(1) In a skin sensitization test with guinea pigs on this substance (three weekly 6-hour epicutaneous applications, application concentration: 100%), no skin sensitization was observed (Patty (6th, 2012)).
5 Germ cell mutagenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Evidence Data]
(1) There were no in vivo data.
(2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test (Patty (6th, 2012)).
6 Carcinogenicity Classification not possible
-
-
- - [Rationale for the Classification]
No data available.
7 Reproductive toxicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 3 (respiratory tract irritation).

[Evidence Data]
(1) In an inhalation toxicity test with rats exposed to processing fumes at concentrations higher than those expected in the workplace, no death or signs of toxicity were observed during the 6-hour exposure. Signs of eye and nasal irritation were observed but disappeared shortly after the animals were removed from the exposure chamber. At the necropsy, there were no treatment-related changes in tissues or organs (Patty (6th, 2012)).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory organs)


Warning
H373 P260
P314
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 2 (respiratory organs).

[Evidence Data]
(1) In an inhalation toxicity test with rats exposed to dust of this substance for 13 weeks (6 hours/day, 5 days/week), increases in absolute and relative lung weight, mild acute or chronic pulmonary inflammation, and increased thymic/peribronchial lymph node histiocytosis were observed at 50 m/m3 (converted guidance value: 0.036 mg/L, within the range for Category 2) (Patty (6th, 2012)).

[Reference Data, etc.]
(2) In a 22-month feeding test with rats and a two-year feeding test with dogs, no treatment-related effects were observed (Patty (6th, 2012)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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