Item | Information |
---|---|
CAS RN | 25134-01-4 |
Chemical Name | Polymer of 2,6-dimethylphenol |
Substance ID | R02-B-106-MHLW |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2017 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. It was classified as "Not classified." |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Patty (6th, 2012)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] Rats were exposed to concentrations that would likely occur in workplace situations for 6 hours, but no deaths or signs of toxicity were noted. Signs of eye and nasal irritation were observed but disappeared shortly after the animals were removed from the exposure chamber. No anomalies were found at gross necropsy (Patty (6th, 2012)). |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). The previous classification was "Classification not possible" by referring to the same evidence data, but it was judged that it could be used as the evidence data for classification from experiment conditions (applied amount and application time). [Evidence Data] (1) In a skin irritation test by 4-hour application of this substance (500 mg) to rabbits, no irritation was seen (Patty (6th, 2012)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There were data of (1), but the classification was not possible. The previous classification was Category 2B by using the same data as the evidence data, but the classification was not possible because detailed information such as the number of animals and scores was lacking. [Reference Data, etc.] (1) It is reported that in an eye irritation test with rabbits on this substance, within 1 hour after application, redness of the conjunctivae and chemosis were observed but resolved by 48 hours, and it produced mild and transient irritation (Patty (6th, 2012)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] There were data of (1), but details of test methods were unknown, and it was classified as "Classification not possible" due to lack of data. [Reference Data, etc.] (1) In a skin sensitization test with guinea pigs on this substance (three weekly 6-hour epicutaneous applications, application concentration: 100%), no skin sensitization was observed (Patty (6th, 2012)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) There were no in vivo data. (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test (Patty (6th, 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) In an inhalation toxicity test with rats exposed to processing fumes at concentrations higher than those expected in the workplace, no death or signs of toxicity were observed during the 6-hour exposure. Signs of eye and nasal irritation were observed but disappeared shortly after the animals were removed from the exposure chamber. At the necropsy, there were no treatment-related changes in tissues or organs (Patty (6th, 2012)). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (respiratory organs) |
Warning |
H373 | P260 P314 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2 (respiratory organs). [Evidence Data] (1) In an inhalation toxicity test with rats exposed to dust of this substance for 13 weeks (6 hours/day, 5 days/week), increases in absolute and relative lung weight, mild acute or chronic pulmonary inflammation, and increased thymic/peribronchial lymph node histiocytosis were observed at 50 m/m3 (converted guidance value: 0.036 mg/L, within the range for Category 2) (Patty (6th, 2012)). [Reference Data, etc.] (2) In a 22-month feeding test with rats and a two-year feeding test with dogs, no treatment-related effects were observed (Patty (6th, 2012)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|