NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	13477-10-6
Chemical Name	Dihypochlorous acid barium salt
Substance ID	R02-B-109-MHLW
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2007
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" because it is classified in Division 5.1, PG II in UNRTDG (UN2741), and it is considered to be not applicable to pyrophoric substances, hazards of the highest precedence.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Ba), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from obtained data: it is slightly soluble in water (HSFS (2001)).
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Category 2	Danger	H272	P370+P378 P210 P220 P280 P501	It was classified in Category 2 because it is classified in Division 5.1, PG II in UNRTDG (UN2741).
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] There were no data on this substance itself, but it was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) In the same way that calcium hypochlorite (CAS RN 7778-54-3) is corrosive to the skin due to the alkalinity of the hypochlorite ion (AICIS (formerly, NICNAS) IMAP (2015)), this substance was considered to be corrosive to the skin.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) This substance was classified in Category 1 in skin corrosion/irritation (GHS classification result in FY2020).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] There was no information on this substance itself, but because this substance was considered to dissociate into the hypochlorite ion and barium ion in aqueous solutions, an investigation was conducted based on information on sodium hypochlorite (CAS RN 7681-52-9) and barium chloride, dihydrate (CAS RN 10326-27-9). From (1) - (4), it was classified as "Classification not possible" due to lack of in vivo data on barium chloride, dihydrate. [Evidence Data] (1) As for in vivo data on sodium hypochlorite (CAS RN 7681-52-9), it was reported to be negative in micronucleus tests using the bone marrow after intraperitoneal or oral administration to mice, negative in a chromosomal aberration test using the bone marrow after oral administration to mice, and negative in a DNA damage test after oral administration to rats (EURAR (2007), NTP TR392 (1992), Patty (6th, 2012)). (2) As for in vitro data on sodium hypochlorite, it is reported that bacterial reverse mutation tests gave negative and positive results, chromosomal aberration tests with cultured mammalian cells gave negative and positive results (EURAR (2007), NTP TR392 (1992)), and a sister chromatid exchange test with cultured mammalian cells was positive (EURAR (2007)). (3) There were no in vivo data on barium chloride, dihydrate (CAS RN 10326-27-9). (4) As for in vitro data on barium chloride, dihydrate, it was reported to be negative in a bacterial reverse mutation test, and a chromosomal aberration test and a sister chromatid exchange test (SCE) with cultured mammalian cells, and positive in a mouse lymphoma test (CEBS (Access on August 2019), NTP TR432 (1994)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] No classification results by domestic and international organizations or carcinogenicity reports were obtained for this substance, but because this substance was considered to dissociate into the hypochlorite ion and barium ion in aqueous solutions, it was classified as "Not classified" from classification results by other organizations in (1) and carcinogenicity test results in experimental animals for sodium hypochlorite in (2) and (3). [Evidence Data] (1) As for classification results by domestic and international organizations, ACGIH classified barium and soluble barium compounds in A4 (ACGIH (7th, 2001)). And IARC classified hypochlorite salts in Group 3 (IARC 52 (1991)), although this substance was not included. (2) In a 104-week drinking water administration test in rats and a 103-week drinking water administration test in mice both using sodium hypochlorite (CAS RN 7681-52-9), no significant increase in tumor incidences was observed (IARC 52 (1991)). (3) In a carcinogenicity test with mice using sodium hypochlorite in the dermal route, no carcinogenicity was seen (IARC 52 (1991)).
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] There were no data on this substance, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, classification was made based on the data of hypochlorous acid (CAS RN 7790-92-3) and water-soluble barium. Based on the data of hypochlorous acid, it could be considered that there were generally no reproductive effects, however, since there were no data on developmental toxicity when administerted only during the organogenesis period, it was determined that classification was not possible due to lack of data. As for barium ions, classification was not possible. From the above, classification was not possible due to lack of data. [Evidence Data] (1) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, body weight depression, alterations in sperm count, sperm motility, or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-related effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (2) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) In the EURAR (2007), there were no data of sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that, although the data available were limited, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. It was stated that, similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). (4) As for reproductive effects of barium salt, classification was not possible due to lack of information for barium chloride (CAS RN 10361-37-2) and barium carbonate (CAS RN 513-77-9) (GHS Classification Results in FY2014).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, cardiovascular system, muscle, digestive organ), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	[Rationale for the Classification] There was no information on this substance, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and water-soluble barium compounds. Based on (1) to (4), it was classified in Category 1 (nervous system, cardiovascular system, muscle, digestive organs) and Category 3 (respiratory tract irritation). New information sources were used and the classification results were changed from the previous classification. [Evidence Data] (1) It was reported that barium and its soluble compounds caused irritation of the eyes and skin, gastrointestinal distress including nausea, vomiting, colic, and diarrhea, and myocardial and other adverse muscular stimulation (ACGIH (7th, 2001)). (2) It was reported that poisoning by barium in humans included acute gastroenteritis, loss of deep reflexes with onset of muscular paralysis, and progressive muscular paralysis (EHC 107 (1990)). (3) It was reported that, in rats, the effects of barium ingestion included salivation, nausea, diarrhea, tachycardia, hypokalemia, twitching, flaccid paralysis of skeletal muscle, respiratory muscle paralysis, and ventricular fibrillation (EHC 107 (1990)). (4) The specific target organ toxicity (single exposure) of sodium hypochlorite (CAS RN 7681-52-9) was Category 3 (respiratory tract irritation) (GHS Classification Results in FY2020). [Reference Data, etc.] (5) The specific target organ toxicity (single exposure) of barium carbonate (CAS RN 513-77-9) was Category 1 (nervous system, cardiovascular system, muscular system) and Category 3 (respiratory tract irritation) (GHS Classification Results in FY2014). (6) The specific target organ toxicity (single exposure) of barium chloride (CAS RN 10361-37-2) was Category 1 (nervous system, cardiovascular system, muscular system, kidney) and Category 3 (respiratory tract irritation) (GHS Classification Results in FY2006).
9	Specific target organ toxicity - Repeated exposure	Category 1 (cardiovascular system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] There was no information on this substance itself, however, since this substance was considered to dissociate into hypochlorite ions and barium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and water-soluble barium compounds. Based on (3) and (4), repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was considered to be low, but based on the information of water-soluble barium compounds in (1) and (2), it was classified in Category 1 (cardiovascular system). As a result of examination by adding new information, the classification results were changed from the previous classification. [Evidence Data] (1) In a human group in a community who ingested drinking water containing soluble barium, such as barium chloride, an increase in the incidence of hypertension, heart disease, or stroke was reported, and in another similar group, an increase in mortality due to cardiovascular disease and heart disease such as arteriosclerosis was observed (ATSDR (2007)). (2) It was reported that the incidence of hypertension increased in workers exposed to soluble barium of an average of 1.07 mg/m3 by mixing and grinding various grades of barium in a mineral processing facility (CICAD 33 (2001)). (3) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only a decrease in body weight gain, presumably due to low water intake, was observed even when rats and mice were dosed for 90 days and 2 years (EURAR (2007), SIAR (2006)). (4) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 51 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information