NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	144-54-7
Chemical Name	N-methyldithiocarbamic acid; Carbam
Substance ID	R02-B-114-MHLW
Classification year (FY)	FY2020
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine. It was classified as "Not classified."
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] It was classified in Category 4 from (1), (2). [Evidence Data] (1) LD50 for rats (the ammonium salt of this substance (CAS RN 39680-90-5)): females: 402 mg/kg, males: 412 mg/kg (a converted value equivalent to this substance: females: 347 mg/kg, males: 356 mg/kg) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)) (2) LD50 for rats (the ammonium salt of this substance (CAS RN 39680-90-5)): males: 706 mg/kg, females: 744 mg/kg (a converted value equivalent to this substance: males: 609 mg/kg, females: 642 mg/kg) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] The category could not be determined from (1), and it was classified as "Classification not possible." [Evidence Data] (1) LD50 for rats (the ammonium salt of this substance (CAS RN 39680-90-5)): > 628 mg/kg (a converted value equivalent to this substance: > 542 mg/kg) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LC50 for rats (4 hours) (the ammonium salt of this substance (CAS RN 39680-90-5)): males: 1.98 mg/L, females: 3.20 mg/L (a converted value equivalent to this substance: males: 1.71 mg/L, females: 2.76 mg/L) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Because the data used in the previous classification could be that on the ammonium salt of this substance (CAS RN 39680-90-5), by reviewing information, the classification result was changed from the previous classification. [Reference Data, etc.] (1) In a skin irritation test with rabbits on the ammonium salt of this substance (CAS RN 39680-90-5), erythema was seen, but due to tissue destruction, it was hard to make a judgment (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. Because the data used in the previous classification could be that on the ammonium salt of this substance (CAS RN 39680-90-5), by reviewing information, the classification result was changed from the previous classification. [Reference Data, etc.] (1) In an eye irritation test with rabbits on the ammonium salt of this substance (CAS RN 39680-90-5), slight irritation of the cornea and conjunctiva was observed but disappeared 7 days after application (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] From (1), it was classified in Category 1 based on data on the ammonium salt of this substance (CAS RN 39680-90-5). [Evidence Data] (1) In a skin sensitization test with guinea pigs on the ammonium salt of this substance (CAS RN 39680-90-5) (maximization test), it was reported to be positive (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] From (1) - (3), standard combination tests, including in vivo and in vitro tests, on the ammonium salt of this substance (CAS RN 39680-90-5) were all negative. Because this substance was considered to be similar, it was classified as "Not classified." [Evidence Data] (1) As for in vivo, a micronucleus test with bone marrow cells after single intraperitoneal administration of the ammonium salt of this substance to mice was reported to be negative. And the ammonium salt was reported to be negative in an unscheduled DNA synthesis test with hepatocytes after single oral administration to rats (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). (2) As for in vitro, for the ammonium salt of this substance, a negative result in a bacterial reverse mutation test and positive (S9+) and negative (S9-) results in a chromosomal aberration test with cultured mammalian cells were obtained (same as the above). (3) It is described that it was considered that the ammonium salt of this substance did not have genotoxicity that could pose a problem in vivo (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)).
6	Carcinogenicity	Not classified	- -	-	-	[Rationale for the Classification] No classification results by domestic and international organizations or carcinogenicity reports were obtained for this substance, but from animal test results on the ammonium salt and sodium salt of this substance in (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In combined chronic toxicity/carcinogenicity tests by gavage administration of the ammonium salt of this substance (CAS RN 39680-90-5) to male and female rats and mice for 2 years for rats and 18 months for mice, no treatment-related increases in the incidences of neoplastic lesions were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (2) In a combined chronic toxicity/carcinogenicity test by 2-year gavage administration of the sodium salt of this substance (CAS RN 137-42-8) to male and female rats and a carcinogenicity test by 18-month gavage administration of the sodium salt to mice, no treatment-related increases in the incidences of neoplastic lesions were observed in either test (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). [Reference Data, etc.] (3) The sodium salt of this substance (CAS RN 137-42-8) was classified in L (Likely To Be Carcinogenic To Humans) by EPA (EPA Annual Cancer Report 2019 (Access on November 2020): classified in 2009). (4) In a carcinogenicity test by 2-year drinking water administration of the sodium salt of this substance (CAS RN 137-42-8) to male and female mice, an increased incidence of angiosarcoma in the spleen was observed in males and females. Therefore, EU EFSA concluded that there was limited evidence of the carcinogenicity of this substance (R40, "Limited evidence of carcinogenic effect") (EU EFSA (2011)).
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] No data was available for this substance, but it was classified using the data of the ammonium salt (CAS RN 39680-90-5) and sodium salt (CAS RN 137-42-8) of this substance. In a reproductive study, based on (1), a decrease in the number of live pups, an increase in the number of stillborn pups, etc. were observed at a dose at which parental toxicity was observed. In a developmental toxicity study, based on (2), low body weight, skeletal variations, etc. were observed in fetuses at a dose at which no maternal toxicity was observed, and based on (3) to (6), in multiple studies, an increase in resorption, a decrease in the number of live fetuses, meningocele, etc. were observed in fetuses at a dose at which maternal toxicity was observed. Based on the above, it was classified in Category 1B. Based on the information from a new information source, the classification result was changed from the previous classification. [Evidence Data] (1) In a two-generation reproductive study by oral administration of the ammonium salt of this substance to rats dosed by gavage, at a dose (15 mg/kg/day) at which an increase in liver weight in males and reduced body weight gain in females were observed in parent animals, a decrease in the number of live pups (without significant difference), an increase in the number of stillborn pups (without significant difference), and a decrease in the survival rate of newborns (on postnatal day 0) (significant only in F1 offspring) were observed in male and female offspring (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (2) In a developmental toxicity study by oral administration of the ammonium salt of this substance to female rats dosed by gavage on days 6 to 15 of gestation, at a dose at which no maternal toxicity was observed, low body weights, delayed ossification (cervical vertebral body), and skeletal variations (7th lumbar vertebra) were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (3) In a developmental toxicity study by oral administration of the sodium salt of this substance to female rats dosed by gavage on days 6 to 15 of gestation, at doses at which toxicity (reduced body weight gain, etc.) was observed in dams, meningocele, etc. were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (4) In another developmental toxicity study by oral administration of the sodium salt of this substance to female rats dosed by gavage on days 6 to 15 of gestation, at doses at which toxicity (salivation, incontinence of urine, reduced body weight gain, etc.) was observed in dams, maxillary hypoplasia, cleft lip, internal hydrocephalus, skeletal abnormalities (an increase in unossified cervical vertebral arch, unossified cervical vertebral body, and unossified sternebrae), skeletal variations, etc. were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (5) In a developmental toxicity study by oral administration of the sodium salt of this substance to female rabbits dosed by gavage on days 6 to 18 of gestation, at doses at which toxicity (reduced body weight gain, etc.) was observed in dams, an increase in resorption (without significant difference), an increase in post-implantation embryo loss, a decrease in the number of live fetuses (without significant difference), meningocele, and spina-bifida were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (6) In a developmental toxicity study by oral administration of the sodium salt of this substance to female rabbits dosed by gavage on days 7 to 19 of gestation, at doses at which toxicity (decreased amount of feces, reduced body weight gain, etc.) was observed in dams, complete embryo resorption (9 animals), an increase in early intrauterine deaths, an increase in post-implantation loss, a decrease in the number of live fetuses (without significant difference), meningocele, skeletal abnormalities (7th sternebra), etc. were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). [Reference Data, etc.] (7) In a two-generation reproductive study by oral administration of the sodium salt of this substance to rats dosed by gavage, reduced body weight gain was observed, but no effect on fertility was observed in parent animals and offspring (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (8) In a developmental toxicity study by oral administration of the ammonium salt of this substance to female rabbits dosed by gavage on days 6 to 18 of gestation, a tendency of reduced body weight gain and a decrease in food consumption (days 7 to 19 of gestation) were observed in dams, but no treatment-related effects were observed in fetuses (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] No data was available for this substance, but it was classified using the data of the ammonium salt (CAS RN 39680-90-5) and sodium salt (CAS RN 137-42-8) of this substance. There was no report on acute exposure to this substance in humans. In experimental animals, based on (1) to (7), it was classified in Category 1 (nervous system, respiratory organs). With the addition of new information, the classification results were changed from the previous classification. [Evidence Data] (1) In an acute oral toxicity test with rats using the ammonium salt of this substance, at or above 356 mg/kg (within the range for Category 2), a decrease in locomotor activity, crouching, salivation and lacrimation, lying on belly, and soiled fur in the lower neck, chest, and around the anus were observed, and from the day following the treatment, reduced body weight gain was observed in all treated groups. In the animals that died, retention of pleural effusion and ascites, and stomach mucosal hyperemia and hemorrhage were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (2) In an acute oral toxicity test with mice using the ammonium salt of this substance, at or above 228 mg/kg (within the range for Category 1), a decrease in locomotor activity, salivation, tonic convulsions, crouching, lying on belly, and soiled fur in the lower neck and around the chest were observed, and from the day following the treatment, reduced body weight gain was observed in all treated groups. In necropsy findings, retention of pleural effusion and ascites, gas-filled stomachs, and retention of serous fluid in the stomach were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (3) In a 4-hour inhalation exposure test with rats using the ammonium salt of this substance, at or above 0.694 mg/L (within the range for Category 1), a decrease in locomotor activity, salivation, crouching, eyelid ptosis, a decrease in respiration, smudge around the snout, soiled fur, and lying on belly were observed. In the animals that died (males: 1.03 mg/L, females: 1.63 mg/L (both within the range for Category 2)), dark red lung, intratracheal foams, gastrointestinal gas, black spots in the glandular stomach mucosa, dark red spots in the thymus, white spots in the liver, and pale in color in the kidney and spleen were observed, and in the animals that survived, contractile dysfunction of the lung in males at or above 1.63 mg/L (within the range for Category 2), atrophy of the thymus in 1 animal at 2.76 mg/L (within the range for Category 2), and black spots in the glandular stomach mucosa in 1 female at 2.76 mg/L (within the range for Category 2) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (4) In an acute oral toxicity test with rats using the sodium salt of this substance (the minimum dose at which effects were observed was not described, and it was assumed that effects were observed at around the dose at which deaths began to be observed (males: 440 mg/kg, females: 552 mg/kg, within the range for Category 2 in both sexes)), sedation, eyelid ptosis, and salivation were observed in all treated groups. Convulsions, cyanosis, retention of the test substance in the stomach, desquamation and thickening of the forestomach mucosa, and hydrops of the forestomach submucosa were observed in the animals that died, and hyperkeratosis of the forestomach mucosa, proliferation of forestomach epithelial cells, and slight thickening of forestomach submucosa were observed in the animals that survived (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (5) In an acute dermal application test with rats using the sodium salt of this substance (the minimum dose at which effects were observed was not described, and it was assumed that effects were observed at around the dose at which deaths began to be observed (males: 5,700 mg/kg (exceeding Category 2), females: 871 mg/kg (within the range for Category 2)), sedation, salivation, and eyelid ptosis were observed, and cyanosis and convulsions in the animals that died, and scabbing and cicatricial changes in the application portion of the skin in the animals that survived were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (6) In an inhalation exposure test with rats using the sodium salt of this substance (the exposure time was unknown, the minimum dose at which effects were observed was not described, and it was assumed that effects were observed at around the dose at which deaths began to be observed (males: 840 mg/m3, females: 1,280 mg/m3)), a decrease in locomotor activity, abnormal breathing, reddening of the limbs and nose, swelling and scabbing of the front limbs, miosis, and lacrimation were observed, and red lungs or red spots on the lungs were observed in the animals that died (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (7) In a general pharmacological test (oral) with mice using the sodium salt of this substance, a decrease in grooming and a slight decrease in locomotor activity at or above 100 mg/kg (within the range for Category 1); a slight pupillary enlargement, lacrimation, and subnormal temperature at or above 300 mg/kg (upper limit of Category 1); and piloerection, and subnormal temperature at 1,000 mg/kg (within the range for Category 2) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver), Category 2 (blood system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	[Rationale for the Classification] No data was available for this substance, but it was classified using the data of the ammonium salt (CAS RN 39680-90-5) and sodium salt (CAS RN 137-42-8) of this substance. There was no report on repeated exposure to these substances in humans. In test animals, based on (1) to (4), effects on the liver at a dose of Category 1 or Category 2, and effects on the blood system at a dose of Category 2 were observed in both substances, and therefore, it was classified in Category 1 (liver) and Category 2 (blood system). Effects on the stomach were also observed in both substances, but since they were considered to be findings due to irritation, the stomach was not adopted as a target organ. With the addition of new information, the classification results were changed from the previous classification. [Evidence Data] (1) It was reported that, in a 90-day test with rats dosed by gavage using the ammonium salt of this substance, at or above 10 mg/kg/day (a converted value equivalent to this substance: 8.6 mg/kg/day, within the range for Category 1), hyperkeratosis and mucosal epithelial thickening of the forestomach were observed, and in males, an increase in the total excretion of sodium was also observed; and at 50 mg/kg/day (within the range for Category 2), salivation, an increase in total cholesterol, an increase in relative liver weight, and centrilobular hepatocyte hypertrophy were observed, and in males, increases in urinary volume and total excretion of chlorine, an increase in platelet count, increases in phospholipid, albumin, and A/G ratio, an increase in absolute liver weight, and hyperplasia of the mucosal epithelium of the glandular stomach were also observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (2) It was reported that, in a one-year oral toxicity test with dogs dosed by capsules using the ammonium salt of this substance, at or above 3 mg/kg/day (a converted value equivalent to this substance: 2.6 mg/kg/day, within the range for Category 1), vomiting, salivation, and an increase in AST were observed, and in males, increases in ALT and ALP, and mononuclear cell infiltration of the liver were also observed; and at 15 mg/kg/day (a converted value equivalent to this substance: 13 mg/kg/day, within the range for Category 2), animals died or were sacrificed in extremis (all males and 3/4 females by week 21 after the administration), and in these animals, single cell necrosis of the liver, mononuclear cell infiltration of the liver, stomach mucosa epithelium proliferation, single cell necrosis of the liver (males only), and an increase in leukocyte count (males only) were observed, and findings observed in females other than those before death or sacrifice in extremis were decreases in red blood cell count, hematocrit (Ht), and hemoglobin (Hb), prolonged activated partial thromboplastin time (APTT), increases in ALT, ALP, LDH, and total bilirubin, and mononuclear cell infiltration of the liver. It was reported that, at 100 mg/kg/day (a converted value equivalent to this substance: 86 mg /kg/day, within the range for Category 2), all animals died or were sacrificed in extremis by week 3 after the administration, and in these animals, vacuolar degeneration of the hepatocytes, stomach mucosa epithelium proliferation, and an increase in platelet count (males only) were observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)). (3) It was reported that, in a 13-week oral toxicity test with rats dosed by gavage using the sodium salt of this substance, at or above 20 mg/kg/day (a converted value equivalent to this substance: 7.0 mg/kg/day, within the range for Category 1), hyperkeratosis of the forestomach mucosa was observed; at or above 60 mg/kg/day (a converted value equivalent to this substance: 20.9 mg/kg/day, within the range for Category 2), an increase in mean corpuscular volume (MCV) and hyperplasia of the forestomach mucosa epithelium were observed, and diffuse hepatocyte hypertrophy and hyperplasia of the urinary bladder mucosa epithelium in males, and an increase in mean corpuscular hemoglobin (MCH) and a decrease in erythrocyte count in females were also observed; and at or above 200 mg/kg/day (a converted value equivalent to this substance: 70 mg/kg/day, within the range for Category 2), decreases in Ht and Hb, and an increase in the extramedullary hematopoiesis of the spleen were observed, and a decrease in erythrocyte count, an increase in platelet count, and increases in total cholesterol and chlorine in males, and an increase in ALP, weakly alkaline urine, diffuse hepatocyte hypertrophy, an increase in extramedullary hematopoiesis, and hyperplasia of the urinary bladder mucosa epithelium in females were also observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2016)). (4) It was reported that, in a 13-week oral toxicity test with mice dosed by gavage using the sodium salt of this substance, at or above 30 mg/kg/day (a converted value equivalent to this substance: 10.5 mg/kg/day, within the range for Category 2), hyperplasia of the urinary bladder mucosa epithelium was observed, and at or above 100 mg/kg/day (a converted value equivalent to this substance: 34.8 mg/kg/day, within the range for Category 2), hyperkeratosis and epithelial hyperplasia of the forestomach mucosa were observed, and hyperplasia of the urinary bladder mucosa epithelium were also observed in females (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2016)).
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information