GHS Classification Results by the Japanese Government

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GENERAL INFORMATION
Item Information
CAS RN 58011-68-0
Chemical Name 4-(2,4-dichlorobenzoyl)-1,3-dimethyl-5-pyrazolyl 4-toluenesulfonate; Pyrazolate
Substance ID R02-B-116-MHLW
Classification year (FY) FY2020
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."
2 Flammable gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
3 Aerosols Not classified (Not applicable)
-
-
- - Not aerosol products. It was classified as "Not classified."
4 Oxidizing gases Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
5 Gases under pressure Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
6 Flammable liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with self-reactive properties, a sulfonyl group, present in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - Solid (GHS definition). It was classified as "Not classified."
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (S). However, the classification is not possible due to no data.
15 Organic peroxides Not classified (Not applicable)
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."
16 Corrosive to metals Classification not possible
-
-
- - Classification is not possible because test methods applicable to solid substances are not available.
17 Desensitized explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
The application materials for registration of agricultural chemical (1978) used in the previous classification could not be obtained and confirmed. And (1) was regarded as reference data because it was the annual report of a company. Therefore, the classification result was changed from the previous classification.

[Reference Data, etc.]
(1) LD50 for rats: males: 9,550 mg/kg, females: 10,233 mg/kg (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984))
1 Acute toxicity (Dermal) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
The application materials for registration of agricultural chemical (1978) used in the previous classification could not be obtained and confirmed. And (1) was regarded as reference data because it was the annual report of a company. Therefore, the classification result was changed from the previous classification.

[Reference Data, etc.]
(1) LD50 for rats: > 5,000 mg/kg (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984))
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
The application materials for registration of agricultural chemical (1992) used in the previous classification could not be obtained and confirmed. Therefore, the classification result was changed from the previous classification.
2 Skin corrosion/irritation Classification not possible
-
-
- - [Rationale for the Classification]
There was a description of (1), but the application materials for registration of agricultural chemical (1992) used in the previous classification could not be obtained and were not data available for classification. Therefore, the classification was not possible due to lack of data.

[Reference Data, etc.]
(1) This substance was not irritating to the skin (auricle) of rabbits (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - [Rationale for the Classification]
There was a description of (1), but details were unknown, and the application materials for registration of agricultural chemical (1992) used in the previous classification could not be obtained, Therefore, the classification was not possible due to lack of data.

[Reference Data, etc.]
(1) This substance was not irritating to the eye of rabbits (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
4 Respiratory sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data. The classification result was changed because the application materials for registration of agricultural chemical (1986) used in the previous classification could not be obtained.
5 Germ cell mutagenicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

[Reference Data, etc.]
(1) As for in vitro, it was reported to be negative in a bacterial reverse mutation test (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
6 Carcinogenicity Classification not possible
-
-
- - [Rationale for the Classification]
No data available.
The classification result was changed from the previous classification because the application materials for registration of agricultural chemical (1989) used in the previous classification could not be obtained and confirmed.
7 Reproductive toxicity Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data. The application materials for registration of agricultural chemical (1986) used for the previous classification were not available. The annual reports of companies were available but the reliability of the data could not be verified, and they were not adopted as rationales for the classification. Therefore, the classification result was changed from the previous classification.

[Reference Data, etc.]
(1) In a three-generation reproduction toxicity study with rats dosed by feeding, a fertility examination revealed reduced body weight gain, a decrease in the number of pups, and a decrease in lactation index were observed, and a teratogenicity examination showed no teratogenic effect, and a growth examination revealed reduced body weight gain and an increase or decrease in weight of some organs, which was considered to be due to reduced body weight gain during the growing period (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - [Rationale for the Classification]
Classification was not possible due to lack of data. The application materials for registration of agricultural chemical (1986) used for the previous classification were not available. The annual reports of companies were available but the reliability of the data could not be verified, and they were not adopted as rationales for the classification. Therefore, the classification result was changed from the previous classification.

[Reference Data, etc.]
(1) It was reported that, in a 13-week feeding test with mice, an increase in blood glucose level was observed in females at 30 mg/kg/day (within the range for Category 2), and increases in AST and ALT activity were observed in males at 100 mg/kg/day (within the range for Category 2) (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
(2) It was reported that, in a two-year feeding test with dogs, increases in AST, ALT, and ALP activity and an increase in urea nitrogen level were observed at 10 mg/kg/day (within the range for Category 1), and death (1 male), worse general conditions, acceleration of erythrocyte sedimentation rate, an increase in ALP activity, and hepatomegaly were observed at 100 mg/kg/day (within the range for Category 2) (Annual Report of Sankyo Research Laboratories, Vol. 36, supplement (Japan Crop Protection Association, 1984)).
10 Aspiration hazard Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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