GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 69-72-7
Chemical Name Salicylic acid
Substance ID R03-C-015-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2011  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
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- - -
2 Flammable gases -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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-
- - -
8 Self-reactive substances and mixtures -
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-
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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- - -
11 Self-heating substances and mixtures -
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- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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-
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17 Desensitized explosives -
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- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
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- - -
1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310 		[Rationale for the Classification]
Based on (1), it was classified in Category 1. Based on the new findings, the classification result was changed.

[Evidence Data]
(1) It was reported that, in an eye irritation test with rabbits (n=3) (21-day observation), marked irritating effects on the cornea and conjunctivae were observed and the mean scores for cornea and conjunctivae evaluated according to the Draize method were 54.1 (full score: 80) and 10.3 (full score: 20), respectively, and the effects did not fully recover within 21 days of observation (ECHA RAC Opinion (2016), CLH Report (2014), SCCS (2019), REACH registration dossier (Accessed Oct. 2021)).

[Reference Data, etc.]
(2) It was reported that, in an eye irritation test with rabbits (n=6) (72-hour observation), this substance induced severe irritation after 24 hours (mean score of eye irritation: 51.5/110). The severe irritation subsided after 48 hours (the same score: 40.3/110) but the effects were observed even after 72 hours (the same score: 38.7/110) (ECHA RAC Opinion (2016), CLH Report (2014), REACH registration dossier (Accessed Oct. 2021)).
(3) It was reported that, in an in vitro eye irritation test using bovine cornea (BCOP assay), the opacity readings with this substance at the concentrations of 0.1%, 1%, and 10% were 7.2%, 70.2%, and 98.7%, respectively, and this substance was considered a severe irritant (ECHA RAC Opinion (2016), CLH Report (2014), SCCS (2019), REACH registration dossier (Accessed Oct. 2021)).
4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
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-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
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12 Hazardous to the ozone layer -
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- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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