GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 100-51-6
Chemical Name Benzyl alcohol
Substance ID R03-C-016-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2019   FY2008  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases -
-
-
- - -
3 Aerosols -
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-
- - -
4 Oxidizing gases -
-
-
- - -
5 Gases under pressure -
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-
- - -
6 Flammable liquids -
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-
- - -
7 Flammable solids -
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-
- - -
8 Self-reactive substances and mixtures -
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-
- - -
9 Pyrophoric liquids -
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-
- - -
10 Pyrophoric solids -
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-
- - -
11 Self-heating substances and mixtures -
-
-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
-
-
- - -
13 Oxidizing liquids -
-
-
- - -
14 Oxidizing solids -
-
-
- - -
15 Organic peroxides -
-
-
- - -
16 Corrosive to metals -
-
-
- - -
17 Desensitized explosives -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
-
-
- - -
1 Acute toxicity (Dermal) -
-
-
- - -
1 Acute toxicity (Inhalation: Gases) -
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-
- - -
1 Acute toxicity (Inhalation: Vapours) -
-
-
- - -
1 Acute toxicity (Inhalation: Dusts and mists) -
-
-
- - -
2 Skin corrosion/irritation -
-
-
- - -
3 Serious eye damage/eye irritation -
-
-
- - -
4 Respiratory sensitization -
-
-
- - -
4 Skin sensitization Category 1A


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		[Rationale for the Classification]
Based on (1) to (6), it was classified in Category 1A. Also, based on the new findings, the classification result was changed.

[Evidence Data]
(1) The Japan Society For Occupational Health (JSOH) classified this substance in occupational skin sensitizers Group 2 (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2019).
(2) In a patch test on 5,202 patients with suspected contact dermatitis, 48 (0.9%) of all the patients and 2 (1.3%) of 156 patients who developed allergic reaction to cosmetics were sensitized to this substance (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2019).
(3) In an open test with 19 healthy volunteers and 31 patients having dermatitis, 15 healthy people and 17 patients developed skin hives as immediate reactions. In addition, in a patch test, all of the healthy people and patients showed negative results for allergic contact dermatitis as delayed allergy to this substance (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2019).
(4) The Research Institute for Fragrance Materials (RIFM) conducted a maximization test with human volunteers and all the subjects showed negative results, and it was concluded that there was no evidence for irritation or sensitization from the 10% substance contained in petrolatum. In a repeated skin sensitization inducing test with human volunteers, sensitization was observed in 5 of 56 people with 20% solution of this substance, 5 of 46 people with 15% solution, 3 of 110 people with 7.5% solution, 2 of 101 people with 5% solution, and no sensitization was observed in any of 107 people with 3% solution (OEL Documentations (Occupational Sensitizer classification) (Japan Society For Occupational Health (JSOH), 2019).
(5) It was reported that results of human repeated insult patch tests (HRIPT) with doses of 3 to 20% (3,543 micro g/cm2 to 23,622 micro g/cm2) for induction and challenge pointed towards a weak to moderate skin sensitizing potential of this substance and increasing doses of this substance from 8,858 micro g/cm2 (7.5%) to 23,622 micro g/cm2 (20%) led to increasing numbers of sensitized subjects (EU REACH CoRAP Substance Evaluation Conclusion (2020)).
(6) There were a number of case reports which reported positive reactions to this substance to a varying degree (EU REACH CoRAP Substance Evaluation Conclusion (2020)).

[Reference Data, etc.]
(7) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=4), the stimulation index (SI values) were 1 (2.5%), 0.9 (5%), 0.5 (10%), 0.6 (25%), and 1.2 (50%) (CLH Report (2020), EU REACH CoRAP (2020), REACH registration dossier (Accessed Oct. 2021)).
5 Germ cell mutagenicity -
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6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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-
- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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