GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 2867-47-2
Chemical Name 2-(Dimethylamino)ethyl methacrylate
Substance ID R03-C-018-MHLW, MOE
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2007   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases -
-
-
- - -
3 Aerosols -
-
-
- - -
4 Oxidizing gases -
-
-
- - -
5 Gases under pressure -
-
-
- - -
6 Flammable liquids -
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-
- - -
7 Flammable solids -
-
-
- - -
8 Self-reactive substances and mixtures -
-
-
- - -
9 Pyrophoric liquids -
-
-
- - -
10 Pyrophoric solids -
-
-
- - -
11 Self-heating substances and mixtures -
-
-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
-
-
- - -
13 Oxidizing liquids -
-
-
- - -
14 Oxidizing solids -
-
-
- - -
15 Organic peroxides -
-
-
- - -
16 Corrosive to metals -
-
-
- - -
17 Desensitized explosives -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
-
-
- - -
1 Acute toxicity (Dermal) -
-
-
- - -
1 Acute toxicity (Inhalation: Gases) -
-
-
- - -
1 Acute toxicity (Inhalation: Vapours) -
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-
- - -
1 Acute toxicity (Inhalation: Dusts and mists) -
-
-
- - -
2 Skin corrosion/irritation -
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-
- - -
3 Serious eye damage/eye irritation -
-
-
- - -
4 Respiratory sensitization -
-
-
- - -
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		[Rationale for the Classification]
Based on (1) to (3), it was classified in Category 1. Also, based on the new findings, the classification result was changed.

[Evidence Data]
(1) It was reported that, in a study of 1,632 patients in the dental field conducted in 1995 to 2004, a patch test with 0.2% of this substance was given to 48 patients who showed positive reactions to one or more methacrylate compounds and positive reactions were observed in 4 people (2 dental patients and 2 dental workers) (DFG MAK (2014)).
(2) From several case reports indicating positive results in patch tests with this substance in patients having eczema, it could be concluded that this substance induced sensitization in humans (DFG MAK (2014)).
(3) It was reported that patch tests on 79 dentists (72 women, 7 men) and 46 dental nurses (women) in Poland who were suspected of occupational allergic contact dermatitis were conducted in 1990 to 2000, and as a result, one person showed positive reactions to this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), Environmental Risk Assessment for Chemical Substances, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2006), DFG MAK (2014)).

[Reference Data, etc.]
(4) It was reported that, in a maximization test (OECD TG 406, GLP, intradermal induction: 1% solution) with guinea pigs (n=20), the positive rate was 0% (0/20 animals) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Hazard Assessment Report (CERI, NITE, 2007), DFG MAK (2014), REACH registration dossier (Accessed Oct. 2021)).
(5) In the ECHA, it was classified in Skin Sens. 1.
(6) In the DFG, it was classified in Sh.
5 Germ cell mutagenicity -
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- - -
6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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-
- - -
10 Aspiration hazard -
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- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 2
-
-
H401 P273
P501 		It was classified in Category 2 from 72-hour ErC50 = 9.0 mg for algae (Raphidocelis subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997)).
11 Hazardous to the aquatic environment Long term (Chronic) Category 2


-
H411 P273
P391
P501 		If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN) and 21-day NOEC = 0.48 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (fish), then it is classified in Category 3 due to being not rapidly degradable and 96-hour LC50 = 19 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997), Initial Risk Assessment (NITE, CERI, NEDO, 2008)).
By drawing a comparison between the above results, it was classified in Category 2. The classification result was revised from the previous classification by changing how to classify it in chronic toxicity and using new information.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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