Item | Information |
---|---|
CAS RN | 77-58-7 |
Chemical Name | Dibutyltin dilaurate |
Substance ID | R03-C-020-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2012 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) to (5), it was classified in Category 2 in consideration of the findings on dibutyltin dichloride, which is a hydrolysate of this substance in the stomach. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) As for in vivo, positive results were reported in a comet assay using the rat cerebral cortical cells after 7-week repeated oral administration (CLH Report (2014), ECHA RAC Opinion (2015)). (2) As for in vitro, this substance was all negative in four bacterial reverse mutation tests (CLH Report (2014), ECHA RAC Opinion (2015), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2018)). (3) For dibutyltin dichloride (DBTC, CAS RN 683-18-1), which is a hydrolysate of this substance in the stomach, as for in vivo, in two in vivo micronucleus tests (OECD TG 474, GLP) using mouse bone marrow, positive and negative results were reported. However, since there was no reason to reject either result, the positive results were adopted (CLH Report (2014), ECHA RAC Opinion (2015)). (4) For DBTC, as for in vitro, in a bacterial reverse mutation assay and a gene mutation test using the cultured mammalian cells, positive and negative results were obtained, and in a chromosomal aberration test using the cultured mammalian cells, positive results were obtained (CLH Report (2014)). (5) The EU classified this substance in Muta. 2 (EU CLP Classification Results (Accessed Oct. 2021)) in consideration of the data of DBTC in exposure through the oral route since it was suggested from an in vitro test that this substance was hydrolyzed into DBTC in the acidic stomach (CLH Report (2014), ECHA RAC Opinion (2015)). [Reference Data, etc.] (6) DBTC, which is a metabolite of this substance, is classified in Category 2 in Japan (GHS classification result in FY2016) and in Muta. 2 in the EU (EU CLP Classification Results (Accessed Oct. 2021)) in the current classification. |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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