Item | Information |
---|---|
CAS RN | 99-08-1 |
Chemical Name | 3-Nitrotoluene |
Substance ID | R03-C-025-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2018 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. The DFG classified this substance in Category 3. However, since the classification by the DFG was based on analogy of the analogous compound (4-nitrotoluene) and no evidence for this substance itself could be obtained in either epidemiological or animal experiments, it was not used for classification. [Reference Data, etc.] (1) As for the classification results by domestic and international organizations, the DFG classified it in Category 3 (DFG MAK (2007)), as is the case with 4-nitrotoluene (CAS RN 99-99-0) which is an isomer of this substance, based on the data of (2) and (3). In addition, the IARC classified it in Group 3 (IARC 65 (1996)). (2) 4-nitrotoluene and this substance have almost the same metabolic pathway and exhibit qualitatively and quantitatively similar effects (DFG MAK (2007)). (3) It was reported that, in a carcinogenicity study for 4-nitrotoluene used as a test substance with rats dosed by feeding for two years, a significant increase in the incidence of clitoral gland adenoma and/or carcinoma in females and a significant increase of subcutaneous fibroma and of subcutaneous fibroma or fibrosarcoma (combined) in males were observed at 2,500 ppm, and there was equivocal evidence of carcinogenic activity in males and some evidence of carcinogenic activity in females (NTP TR498 (2002)). (4) It was reported that, in a test for 4-nitrotoluene used as a test substance with B6C3F1 mice dosed by feeding for 105 or 106 weeks, an increase in the total incidences of bronchiolar/alveolar adenomas and carcinomas was observed in males at 5,000 ppm, and there was equivocal evidence of carcinogenic activity of this substance in males. Besides, as preneoplastic lesions related to lung neoplasms observed in males, alveolar bronchiolization and hyperplasia were observed in males and females (NTP TR498 (2002)). |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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