GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 99-08-1
Chemical Name 3-Nitrotoluene
Substance ID R03-C-025-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2018   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives -
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2 Flammable gases -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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8 Self-reactive substances and mixtures -
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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11 Self-heating substances and mixtures -
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12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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17 Desensitized explosives -
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HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) -
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1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation -
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4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity Classification not possible
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- - [Rationale for the Classification]
Classification not possible due to lack of data. The DFG classified this substance in Category 3. However, since the classification by the DFG was based on analogy of the analogous compound (4-nitrotoluene) and no evidence for this substance itself could be obtained in either epidemiological or animal experiments, it was not used for classification.

[Reference Data, etc.]
(1) As for the classification results by domestic and international organizations, the DFG classified it in Category 3 (DFG MAK (2007)), as is the case with 4-nitrotoluene (CAS RN 99-99-0) which is an isomer of this substance, based on the data of (2) and (3). In addition, the IARC classified it in Group 3 (IARC 65 (1996)).
(2) 4-nitrotoluene and this substance have almost the same metabolic pathway and exhibit qualitatively and quantitatively similar effects (DFG MAK (2007)).
(3) It was reported that, in a carcinogenicity study for 4-nitrotoluene used as a test substance with rats dosed by feeding for two years, a significant increase in the incidence of clitoral gland adenoma and/or carcinoma in females and a significant increase of subcutaneous fibroma and of subcutaneous fibroma or fibrosarcoma (combined) in males were observed at 2,500 ppm, and there was equivocal evidence of carcinogenic activity in males and some evidence of carcinogenic activity in females (NTP TR498 (2002)).
(4) It was reported that, in a test for 4-nitrotoluene used as a test substance with B6C3F1 mice dosed by feeding for 105 or 106 weeks, an increase in the total incidences of bronchiolar/alveolar adenomas and carcinomas was observed in males at 5,000 ppm, and there was equivocal evidence of carcinogenic activity of this substance in males. Besides, as preneoplastic lesions related to lung neoplasms observed in males, alveolar bronchiolization and hyperplasia were observed in males and females (NTP TR498 (2002)).
7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
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11 Hazardous to the aquatic environment Long term (Chronic) -
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12 Hazardous to the ozone layer -
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NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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