GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 10124-43-3
Chemical Name Cobalt(II) sulfate
Substance ID R03-C-033-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2018   FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
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2 Flammable gases -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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8 Self-reactive substances and mixtures -
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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11 Self-heating substances and mixtures -
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12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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17 Desensitized explosives -
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HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
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1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation -
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4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501 		[Rationale for the Classification]
Although the available data on this substance and its hydrates was only (1) and (2), it can be considered that water-soluble divalent cobalt compounds have common characteristics based on (3) and (4). Therefore, as for the potential toxicity of this substance, the classification result of cobalt (II) dichloride, on which the data that can be used for classification was richest, was applied, and it was classified in Category 2.

[Evidence Data]
(1) For this substance, both positive and negative results in vitro were obtained in a bacterial reverse mutation test. As for in vivo, however, there was no data available (AICIS IMAP (2014)).
(2) For cobalt sulfate heptahydrate (CAS RN 10124-43-3), negative results in vivo were obtained in a chromosome aberration test using the bone marrow cells of rats (single oral gavage dose, up to 320 mg/kg) (AICIS IMAP (2014)).
(3) This substance is a soluble cobalt compound and the data of cobalt (II) dichloride (CAS RN 7646-79-9), which is divalent soluble cobalt, can be used. This is because both substances are considered to cause adverse effects directly by released divalent cobalt ion after being taken into the body and the read across principles of the OECD are applicable (AICIS IMAP (2014), ECHA RAC & SEAC Final Opinion (Background Doc.) (2020)).
(4) Cobalt (II) dichloride, on which the mutagenicity data is richest, was classified in Category 2 for this hazard class (GHS classification result in FY2015).

[Reference Data, etc.]
(5) In the EU, this substance was classified as Muta. 2 (REACH registration dossier (Accessed Oct. 2021)). Besides, this substance was identified as SVHC based on the classification for carcinogenicity and reproductive toxicity (EU REACH SVHC Support Document (2010)).
6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
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11 Hazardous to the aquatic environment Long term (Chronic) -
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12 Hazardous to the ozone layer -
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NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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