GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 62-73-7
Chemical Name Dimethyl 2,2-dichlorovinyl phosphate (synonym: DDVP)
Substance ID R03-C-052-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2011   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
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2 Flammable gases -
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3 Aerosols -
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4 Oxidizing gases -
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5 Gases under pressure -
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6 Flammable liquids -
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7 Flammable solids -
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8 Self-reactive substances and mixtures -
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9 Pyrophoric liquids -
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10 Pyrophoric solids -
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11 Self-heating substances and mixtures -
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12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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15 Organic peroxides -
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16 Corrosive to metals -
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17 Desensitized explosives -
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HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) -
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1 Acute toxicity (Dermal) -
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1 Acute toxicity (Inhalation: Gases) -
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1 Acute toxicity (Inhalation: Vapours) -
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1 Acute toxicity (Inhalation: Dusts and mists) -
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2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation -
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4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity Category 1B


Danger
H350 P308+P313
P201
P202
P280
P405
P501 		[Rationale for the Classification]
Based on (1) and (2), an increase in the incidence of tumors including malign ones was observed in two animal species (malignant fibrous histiocytoma in male rat, forestomach tumor in female mice), and in animal studies, it was considered that there was sufficient evidence of carcinogenicity, and therefore, this substance was classified in Category 1B.

[Evidence Data]
(1) In a carcinogenicity study with rats and mice dosed by feeding for 80 weeks (after the dosing period, rats were observed for 30 weeks and mice were observed for 12 to 14 weeks before sacrifice), a dose-dependent increase in the incidence of malignant fibrous histiocytoma was observed in male rats (0, 150, 1,000/300 ppm). But there was no significant increase in tumors in female rats and male and female mice (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2013), IARC 53 (1991), ACGIH (2014)).
(2) In a carcinogenicity study with rats and mice dosed by gavage for 2 years (5 days/week), in the test with rats (males and females: 0, 4, 8 mg/kg/day), dose-dependent increases in the incidences of pancreatic acinar cell adenomas and mononuclear cell leukemia in males and mammary gland tumors with mammary gland fibromas and fibroadenomas combined in females were observed. The NTP concluded that some evidence of carcinogenicity for male rats and equivocal evidence for female rats were obtained. In contrast, in the test with mice (males: 0, 10, 20 mg/kg/day, females: 0, 20, 40 mg/kg/day), a dose-dependent increase in forestomach papillomas was observed in both males and females. At 40 mg/kg/day, a significant increase in the incidence of forestomach papillomas was observed in females compared to controls, and squamous cell carcinomas were also observed in 2/50 animals. The NTP concluded that some evidence of carcinogenicity for male mice and clear evidence for female mice were obtained (NTP TR342 (1989), Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2013), IARC 53 (1991), ACGIH (2014)).
(3) This substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act (guidelines in order to prevent the impairment of worker's health, announcement No. 27 on February 7, 2020).
(4) As for the classification results by domestic and international organizations, the IARC classified this substance in Group 2B (IARC 53 (1991)), the Japan Society For Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2021): proposed in 2001), the EPA classified it in S (EPA OPP Annual Cancer Report (2020): 2000), and the ACGIH classified it in A4 (ACGIH (2014): proposed in 2000).

[Reference Data]
(5) The ACGIH assessed the test results including (1) and (2) and concluded that the tumors observed in rats and mice were inconsistent and the relevance of forestomach tumors, etc. to humans was unclear. Therefore, it was classified in A4 (ACGIH (2014)).
7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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9 Specific target organ toxicity - Repeated exposure -
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10 Aspiration hazard -
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ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
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11 Hazardous to the aquatic environment Long term (Chronic) -
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12 Hazardous to the ozone layer -
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- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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