NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	67-66-3
Chemical Name	Chloroform
Substance ID	R03-C-059-MHLW
Classification year (FY)	FY2021
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)
New/Revised	Revised
Classification result in other fiscal year	FY2015 FY2014 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solids	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-
17	Desensitized explosives	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	[Rationale for the Classification] Based on (1) to (4), it was classified in Category 4. [Evidence Data] (1) LD50 for rats (males): 908 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (2) LD50 for rats (females): 1,117 mg/kg (OECD TG 401) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2009), DFG MAK (2000)) (3) LD50 for rats (males): 445 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), ATSDR, (1997), CLH Report (2010)) (4) LD50 for rats (males): 2,000 mg/kg (ATSDR (1997), DFG MAK (2000), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), the data on rabbits was adopted and it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: > 3,980 mg/kg (AICIS IMAP (2014)) [Reference Data, etc.] (2) LD50 for mice: between 696 to 3,245 mg/kg (Hazard Assessment Report (CERI, NITE, 2006))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified."
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3 by adopting the category with the higher hazard. Also, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (233,290 ppm), it was judged to be a vapor and classified based on the reference value in units of ppmV. Based on the new findings, the classification result was changed. [Evidence Data] (1) LC50 (6 hours) for rats: 9.2 g/m3 (converted 4-hour equivalent value: 11.3 g/m3, 2,310 ppm) (Risk Assessment Documents (National Institute of Advanced Industrial Science and Technology, 2007), EURAR (2007), AICIS IMAP (2014)) (2) LC50 (4 hours) for rats: 9,770 ppm (ATSDR (1997), US AEGL (2012)) (3) LC50 (4 hours) for rats: 47,702 mg/m3 (9,775 ppm) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 1999)) [Reference Data, etc.] (4) This substance was classified in Category 3 in the EU CLH.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	-	- -	-	-	-
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment Long term (Chronic)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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