GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 7718-54-9
Chemical Name Nickel chloride
Substance ID R03-C-060-MHLW, MOE
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009   FY2008   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases -
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-
- - -
3 Aerosols -
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-
- - -
4 Oxidizing gases -
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-
- - -
5 Gases under pressure -
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-
- - -
6 Flammable liquids -
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-
- - -
7 Flammable solids -
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-
- - -
8 Self-reactive substances and mixtures -
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-
- - -
9 Pyrophoric liquids -
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-
- - -
10 Pyrophoric solids -
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-
- - -
11 Self-heating substances and mixtures -
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-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
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13 Oxidizing liquids -
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14 Oxidizing solids -
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-
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15 Organic peroxides -
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-
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16 Corrosive to metals -
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-
- - -
17 Desensitized explosives -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501 		[Rationale for the Classification]
Based on (1) to (3), it was classified in Category 3. Besides, based on the converted value equivalent to nickel chloride, the classification result was changed.

[Evidence Data]
(1) LD50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9)) for rats (females): 210 mg/kg (converted value equivalent to nickel chloride: 115 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008))
(2) LD50 (Nickel Chloride Hexahydrate) for rats (males): 175 mg/kg (converted value equivalent to nickel chloride: 95.4 mg/kg) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2017), Hazard Assessment Report (CERI, NITE, 2008))
(3) LD50 (Nickel Chloride Hexahydrate) for rats (females): 500 mg/kg (converted value equivalent to nickel chloride: 273 mg/kg) (OECD TG 425) (AICIS IMAP (2014), EU EFSA (2018))

[Reference Data, etc.]
(4) This substance was classified in Category 3 in the EU CLH.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not classified
-
-
- - [Rationale for the Classification]
Solid (GHS definition). It was classified as "Not classified."
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - [Rationale for the Classification]
Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501 		[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 2. Also, based on the new findings, the classification result was changed.

[Evidence Data]
(1) LC50 (Nickel Chloride Hexahydrate (CAS RN: 7718-54-9), 4 hours) for rats (males): 0.593 mg/L (converted value equivalent to nickel chloride: 0.323 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022))
(2) LC50 (Nickel Chloride Hexahydrate, 4 hours) for rats (females): 0.746 mg/L (converted value equivalent to nickel chloride: 0.407 mg/L) (OECD TG 403, GLP) (REACH registration dossier (Accessed Jan. 2022))
2 Skin corrosion/irritation -
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3 Serious eye damage/eye irritation -
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4 Respiratory sensitization -
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4 Skin sensitization -
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5 Germ cell mutagenicity -
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6 Carcinogenicity -
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7 Reproductive toxicity -
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8 Specific target organ toxicity - Single exposure -
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-
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9 Specific target organ toxicity - Repeated exposure -
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-
- - -
10 Aspiration hazard -
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-
- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) Category 1


Warning
H400 P273
P391
P501 		It was classified in Category 1 from 48-hour LC50 = 0.013 mg Ni/L (a converted value equivalent to this substance: 0.029 mg/L) for crustacea (Ceriodaphnia dubia) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)).
11 Hazardous to the aquatic environment Long term (Chronic) Category 1


Warning
H410 P273
P391
P501 		Sufficient data on rapid degradability were not obtained. It was classified in Category 1 from 17-day NOEC = 0.002 mg/L for crustacea (Ceriodaphnia dubia) (EU RAR, 2008).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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