Item | Information |
---|---|
CAS RN | 97-88-1 |
Chemical Name | n-Butyl methacrylate |
Substance ID | R03-C-066-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2015 FY2007 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | Category 1B |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1B. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=5/group), the Stimulation Index (SI values) were 2.19 (25%), 3.28 (50%), and 5.14 (100%), and the EC3 value was calculated to be 43.6% (REACH registration dossier (Accessed Jan. 2022)). [Reference Data, etc.] (2) It was reported that 243 contact dermatitis patients who had been exposed to acrylate or methacrylate ester were given patch tests with this substance at a concentration of 2% and positive reactions were observed in 6 patients (2.5%) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2013), REACH registration dossier (Accessed Jan. 2022)). (3) 542 dermatitis patients were given patch tests with this substance at a concentration of 1% and one individual showed positive reactions. But this patient had used acrylic paint in the past and the reaction was considered to be associated with it (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2013), REACH registration dossier (Accessed Jan. 2022)). (4) Humans exposed to acrylates were given patch tests with this substance and a very few cases showed positive reactions and confirmed the weak skin sensitization potential of this substance (AICIS IMAP (2014), SIAP (2004), Canada CMP Screening Assessment (2018)). (5) 347 patients suspected to have contact dermatitis were given patch tests and one patient (0.3%) showed positive reactions to this substance at a concentration of 2% (REACH registration dossier (Accessed Jan. 2022)). (6) It was reported that 331 people who had been exposed to (meth)acrylates were given patch tests at a concentration of 2% and 2 people (0.6%) showed positive reactions (REACH registration dossier (Accessed Jan. 2022)). (7) It was reported that, in a Maximization test (OECD TG 406, GLP, intradermal induction: 5% solution) with guinea pigs (n=5), the positive rates in 24 and 48 hours after challenge were 80% (4/5 animals) and 40% (2/50 animals), respectively (REACH registration dossier (Accessed Jan. 2022)). (8) In the DFG, it was classified in Sh (List of MAK and BAT values (2020)). (9) In the ECHA, it was classified in Skin Sens. 1 (EU-CLP Classification Results (Accessed Jan. 2022)). |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | - |
- |
- | - | - |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|