GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 97-88-1
Chemical Name n-Butyl methacrylate
Substance ID R03-C-066-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2015   FY2007   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases -
-
-
- - -
3 Aerosols -
-
-
- - -
4 Oxidizing gases -
-
-
- - -
5 Gases under pressure -
-
-
- - -
6 Flammable liquids -
-
-
- - -
7 Flammable solids -
-
-
- - -
8 Self-reactive substances and mixtures -
-
-
- - -
9 Pyrophoric liquids -
-
-
- - -
10 Pyrophoric solids -
-
-
- - -
11 Self-heating substances and mixtures -
-
-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
-
-
- - -
13 Oxidizing liquids -
-
-
- - -
14 Oxidizing solids -
-
-
- - -
15 Organic peroxides -
-
-
- - -
16 Corrosive to metals -
-
-
- - -
17 Desensitized explosives -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) -
-
-
- - -
1 Acute toxicity (Dermal) -
-
-
- - -
1 Acute toxicity (Inhalation: Gases) -
-
-
- - -
1 Acute toxicity (Inhalation: Vapours) -
-
-
- - -
1 Acute toxicity (Inhalation: Dusts and mists) -
-
-
- - -
2 Skin corrosion/irritation -
-
-
- - -
3 Serious eye damage/eye irritation -
-
-
- - -
4 Respiratory sensitization -
-
-
- - -
4 Skin sensitization Category 1B


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
[Rationale for the Classification]
Based on (1), it was classified in Category 1B. Also, based on the new findings, the classification result was changed.

[Evidence Data]
(1) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=5/group), the Stimulation Index (SI values) were 2.19 (25%), 3.28 (50%), and 5.14 (100%), and the EC3 value was calculated to be 43.6% (REACH registration dossier (Accessed Jan. 2022)).

[Reference Data, etc.]
(2) It was reported that 243 contact dermatitis patients who had been exposed to acrylate or methacrylate ester were given patch tests with this substance at a concentration of 2% and positive reactions were observed in 6 patients (2.5%) (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2013), REACH registration dossier (Accessed Jan. 2022)).
(3) 542 dermatitis patients were given patch tests with this substance at a concentration of 1% and one individual showed positive reactions. But this patient had used acrylic paint in the past and the reaction was considered to be associated with it (Environmental Risk Assessment for Chemical Substances (Ministry of the Environment, 2013), REACH registration dossier (Accessed Jan. 2022)).
(4) Humans exposed to acrylates were given patch tests with this substance and a very few cases showed positive reactions and confirmed the weak skin sensitization potential of this substance (AICIS IMAP (2014), SIAP (2004), Canada CMP Screening Assessment (2018)).
(5) 347 patients suspected to have contact dermatitis were given patch tests and one patient (0.3%) showed positive reactions to this substance at a concentration of 2% (REACH registration dossier (Accessed Jan. 2022)).
(6) It was reported that 331 people who had been exposed to (meth)acrylates were given patch tests at a concentration of 2% and 2 people (0.6%) showed positive reactions (REACH registration dossier (Accessed Jan. 2022)).
(7) It was reported that, in a Maximization test (OECD TG 406, GLP, intradermal induction: 5% solution) with guinea pigs (n=5), the positive rates in 24 and 48 hours after challenge were 80% (4/5 animals) and 40% (2/50 animals), respectively (REACH registration dossier (Accessed Jan. 2022)).
(8) In the DFG, it was classified in Sh (List of MAK and BAT values (2020)).
(9) In the ECHA, it was classified in Skin Sens. 1 (EU-CLP Classification Results (Accessed Jan. 2022)).
5 Germ cell mutagenicity -
-
-
- - -
6 Carcinogenicity -
-
-
- - -
7 Reproductive toxicity -
-
-
- - -
8 Specific target organ toxicity - Single exposure -
-
-
- - -
9 Specific target organ toxicity - Repeated exposure -
-
-
- - -
10 Aspiration hazard -
-
-
- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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