GHS Classification Results by the Japanese Government

Japanese



GENERAL INFORMATION
Item Information
CAS RN 82560-54-1
Chemical Name Benfuracarb
Substance ID R03-C-071-MHLW
Classification year (FY) FY2021
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)
New/Revised Revised
Classification result in other fiscal year FY2018   FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives -
-
-
- - -
2 Flammable gases -
-
-
- - -
3 Aerosols -
-
-
- - -
4 Oxidizing gases -
-
-
- - -
5 Gases under pressure -
-
-
- - -
6 Flammable liquids -
-
-
- - -
7 Flammable solids -
-
-
- - -
8 Self-reactive substances and mixtures -
-
-
- - -
9 Pyrophoric liquids -
-
-
- - -
10 Pyrophoric solids -
-
-
- - -
11 Self-heating substances and mixtures -
-
-
- - -
12 Substances and mixtures which, in contact with water, emit flammable gases -
-
-
- - -
13 Oxidizing liquids -
-
-
- - -
14 Oxidizing solids -
-
-
- - -
15 Organic peroxides -
-
-
- - -
16 Corrosive to metals -
-
-
- - -
17 Desensitized explosives -
-
-
- - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) -
-
-
- - -
1 Acute toxicity (Dermal) -
-
-
- - -
1 Acute toxicity (Inhalation: Gases) -
-
-
- - -
1 Acute toxicity (Inhalation: Vapours) -
-
-
- - -
1 Acute toxicity (Inhalation: Dusts and mists) -
-
-
- - -
2 Skin corrosion/irritation -
-
-
- - -
3 Serious eye damage/eye irritation -
-
-
- - -
4 Respiratory sensitization -
-
-
- - -
4 Skin sensitization -
-
-
- - -
5 Germ cell mutagenicity -
-
-
- - -
6 Carcinogenicity -
-
-
- - -
7 Reproductive toxicity Category 1B


Danger
H360 P308+P313
P201
P202
P280
P405
P501
[Rationale for the Classification]
Since a reduced viability index in pups at the dose that caused general toxicity in parental animals was observed in (1) and (2) and adverse effects on fertility were observed in (2), it was classified in Category 1B. It was classified based on the new information source.

[Evidence Data]
(1) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 30 to 300 ppm), in parental animals, reduced body weight gain and decreased food consumption in P males and females and decreased adrenal weight in females were observed at or above the intermediate dose, and reduced body weight gain (males and females) and decreased food consumption (females) in F1 were observed at the high dose (300 ppm), but no adverse effects on fertility were observed; while in pups, reduced body weight gain in F1 and F2 males and females was observed at or above the intermediate dose and reduced viability index was observed at the high dose in F1 (viability index on postnatal day 4: 86.3%, viability index on postnatal day 14: 89.9%, viability index on postnatal day 21: 89.9%) and in F2 (viability index on postnatal day 4: 92.2%, no statistically significant difference but considered to be the effect of administration of the test substance) (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)).
(2) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 25 to 400 ppm), in the high-dose (400 ppm) group in which reduced body weight gain (about 10%) and increased food consumption (around 20%) in parental animals were observed, decreased male fertility, decreased number of live pups (viability index on postnatal day 4: 41.6% (92/221), viability index on postnatal day 21: 68.5% (63/92)), and lower pup weight (only F1) were observed (EFSA (2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)).

[Reference Data, etc.]
(3) It was reported that, in a developmental toxicity study with female rats dosed by gavage (GLP, 2 to 40 mg/kg/day, days 6 to 19 of gestation), at the highest dose (40 mg/kg/day) that caused maternal toxicity (1/24 death, reduced body weight gain, tremor), slight effects such as decreased body weight and delayed ossification were observed in fetuses (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)).
(4) It was reported that, in a developmental toxicity study with female rabbits dosed by gavage (GLP, 5 to 15 mg/kg/day, days 7 to 29 of gestation), in dams, two deaths were observed at the intermediate dose (10 mg/kg/day) and three deaths and reduced body weight gain were observed at the high dose (15 mg/kg/day); while in fetuses, only decreased body weight was observed at the high dose (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)).
(5) In the EU, it was classified in Repr. 2 (EU CLP Classification Results (Accessed Dec. 2021)).
8 Specific target organ toxicity - Single exposure -
-
-
- - -
9 Specific target organ toxicity - Repeated exposure -
-
-
- - -
10 Aspiration hazard -
-
-
- - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment Short term (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment Long term (Chronic) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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