Item | Information |
---|---|
CAS RN | 82560-54-1 |
Chemical Name | Benfuracarb |
Substance ID | R03-C-071-MHLW |
Classification year (FY) | FY2021 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW) |
New/Revised | Revised |
Classification result in other fiscal year | FY2018 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
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1 | Explosives | - |
- |
- | - | - |
2 | Flammable gases | - |
- |
- | - | - |
3 | Aerosols | - |
- |
- | - | - |
4 | Oxidizing gases | - |
- |
- | - | - |
5 | Gases under pressure | - |
- |
- | - | - |
6 | Flammable liquids | - |
- |
- | - | - |
7 | Flammable solids | - |
- |
- | - | - |
8 | Self-reactive substances and mixtures | - |
- |
- | - | - |
9 | Pyrophoric liquids | - |
- |
- | - | - |
10 | Pyrophoric solids | - |
- |
- | - | - |
11 | Self-heating substances and mixtures | - |
- |
- | - | - |
12 | Substances and mixtures which, in contact with water, emit flammable gases | - |
- |
- | - | - |
13 | Oxidizing liquids | - |
- |
- | - | - |
14 | Oxidizing solids | - |
- |
- | - | - |
15 | Organic peroxides | - |
- |
- | - | - |
16 | Corrosive to metals | - |
- |
- | - | - |
17 | Desensitized explosives | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
- |
- | - | - |
1 | Acute toxicity (Dermal) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Gases) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Vapours) | - |
- |
- | - | - |
1 | Acute toxicity (Inhalation: Dusts and mists) | - |
- |
- | - | - |
2 | Skin corrosion/irritation | - |
- |
- | - | - |
3 | Serious eye damage/eye irritation | - |
- |
- | - | - |
4 | Respiratory sensitization | - |
- |
- | - | - |
4 | Skin sensitization | - |
- |
- | - | - |
5 | Germ cell mutagenicity | - |
- |
- | - | - |
6 | Carcinogenicity | - |
- |
- | - | - |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Since a reduced viability index in pups at the dose that caused general toxicity in parental animals was observed in (1) and (2) and adverse effects on fertility were observed in (2), it was classified in Category 1B. It was classified based on the new information source. [Evidence Data] (1) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 30 to 300 ppm), in parental animals, reduced body weight gain and decreased food consumption in P males and females and decreased adrenal weight in females were observed at or above the intermediate dose, and reduced body weight gain (males and females) and decreased food consumption (females) in F1 were observed at the high dose (300 ppm), but no adverse effects on fertility were observed; while in pups, reduced body weight gain in F1 and F2 males and females was observed at or above the intermediate dose and reduced viability index was observed at the high dose in F1 (viability index on postnatal day 4: 86.3%, viability index on postnatal day 14: 89.9%, viability index on postnatal day 21: 89.9%) and in F2 (viability index on postnatal day 4: 92.2%, no statistically significant difference but considered to be the effect of administration of the test substance) (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)). (2) It was reported that, in a two-generation reproduction toxicity study with rats dosed by feeding (GLP, 25 to 400 ppm), in the high-dose (400 ppm) group in which reduced body weight gain (about 10%) and increased food consumption (around 20%) in parental animals were observed, decreased male fertility, decreased number of live pups (viability index on postnatal day 4: 41.6% (92/221), viability index on postnatal day 21: 68.5% (63/92)), and lower pup weight (only F1) were observed (EFSA (2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019)). [Reference Data, etc.] (3) It was reported that, in a developmental toxicity study with female rats dosed by gavage (GLP, 2 to 40 mg/kg/day, days 6 to 19 of gestation), at the highest dose (40 mg/kg/day) that caused maternal toxicity (1/24 death, reduced body weight gain, tremor), slight effects such as decreased body weight and delayed ossification were observed in fetuses (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)). (4) It was reported that, in a developmental toxicity study with female rabbits dosed by gavage (GLP, 5 to 15 mg/kg/day, days 7 to 29 of gestation), in dams, two deaths were observed at the intermediate dose (10 mg/kg/day) and three deaths and reduced body weight gain were observed at the high dose (15 mg/kg/day); while in fetuses, only decreased body weight was observed at the high dose (Risk Assessment Report (Pesticide) (Food Safety Commission of Japan, 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2019), EFSA (2009)). (5) In the EU, it was classified in Repr. 2 (EU CLP Classification Results (Accessed Dec. 2021)). |
8 | Specific target organ toxicity - Single exposure | - |
- |
- | - | - |
9 | Specific target organ toxicity - Repeated exposure | - |
- |
- | - | - |
10 | Aspiration hazard | - |
- |
- | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
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