Item | Information |
---|---|
CAS RN | 100-43-6 |
Chemical Name | 4-Vinylpyridine |
Substance ID | m-nite-100-43-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 3 |
Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 50 degrees C [closed cup] (GESTIS (Access on Jan. 2011)) is >= 23 degrees C and <= 60 degrees C, therefore, it corresponds to Category 3. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | The classification is not possible due to no data although it contains a chemical group related to self-reactivity (unsaturated bond). Besides, it is class 6.1 subsidiary risk 3, 8PGII in UNRTDG (UN3073: VINYLPYRIDINES, STABILIZED), and it is conceivable that that containing a stabilizer is equivalent to Type G because it does not correspond to self-reactive. In addition, that not containing a stabilizer is judged to be Type A because that corresponds to dangerous goods forbidden from transport in UNRTDG. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 440 degrees C (GESTIS (Access on Jan. 2011)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain oxygen, fluorine, or chlorine. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | An organic compound that does not contain -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of LD50 values of 100-200 mg/kg for rats (PATTY (5th, 2001)), it was classified in Category 3. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data because the category cannot be determined only from a reported LD50 value of < 500 mg/kg bw for guinea pigs (PATTY (5th, 2001)). Besides, it corresponds to Category 3 or lower. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
On the basis of an LC50 value of 0.38 mg/L/2h = 0.27 mg/L/4h = 62.79 ppm/4h for mice (HSDB (2002)), it was classified in Category 1. Besides, a reference value of gasses was applied because the toxicity value (0.38 mg/L = 88.4 ppm) is lower than 90 % of the saturated vapour pressure concentration (2237 ppm). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
On the basis of an evaluation result as "severe skin irritation" in a rabbit test (PATTY (5th, 2001)), it was classified in Category 2. Besides, there is information on vinyl pyrimidine that "direct skin contact with the liquid results in burning pain, followed by fairly severe skin burns" (HSDB (2002)). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
On the basis of a report in which "instillation of the undiluted liquid caused severe eye irritation in rabbits" (PATTY (5th, 2001)), it was classified in Category 2A. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
This substance is listed as sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006). Besides, a positive result in a skin sensitization test by murine LLNA in which the test chemicals demonstrated a greater than threefold increase in lymph node cells proliferation was reported (HSDB (2002)), on the other hand, several skin sensitization results in human exposure to this substance were reported ((Initial Risk Assessment, 18, NITE (2005)), (PATTY (5th, 2001), (HSDB (2002))). It was classified in Category 1 from the above knowledge. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, a negative result in an Ames test in an in vitro test is obtained (PATTY (5th, 2001). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
There is information that human exposure to this substance during laboratory use caused mild and transient irritations to eye, nose, and throat (PATTY (5th, 2001)) and a transient mucous membrane irritation (HSDB (2002)). From a report on a test using rabbits and mice in which accelerated respiration and respiratory distress occurred (HSDB (2002)), it was classified in Category 3 (respiratory tract irritation). |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 96-hour LC50 = 1.0 mg/L for fish (Oryzias latipes) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007), it was classified in Category 1. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 because it is non-rapidly degradable (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 1985)) and 72-hour EC50 = 0.86 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007). If acute toxicity data are used for trophic levels for which chronic toxicity data are lacking, then it is classified in Category 1 because it is non-rapidly degradable (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 1985)) and 96-hour LC50 = 1.0 mg/L for fish (Oryzias latipes) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2007). It was classified in Category 1 by a comparison between the above results. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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