NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10026-24-1
Chemical Name	Cobalt(II) sulfate heptahydrate
Substance ID	m-nite-10026-24-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From the information of being soluble in water (Merck (14th, 2006)), it is recognized that it does not react vigorously with water.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound which does not contain halogen but contains oxygen, however, the classification is not possible due to no data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on 761 mg/kg, which was obtained by molecular weight conversion of an LD50 value of 420 mg/kg for cobalt sulfate anhydrate for rats (NTP TR 471 (1998)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Data lack if it is limited to information on this substance. However, for cobalt and its compounds, it is described in DFGOT vol.23 (2006) that sensitization of the respiratory organs in humans was concluded from investigations on workers in hard metal production/processing and diamond polishing. Therefore, it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is described in DFGOT vol.23 (2006) that in two maximization tests in humans, positive reactions were observed in 10 out of 25 subjects and 42 out of 987 subjects, respectively. Furthermore, three tests with guinea pigs were reported, and it is described that it was positive (positive rate of 100%), although the positive control is unknown in all. Therefore, it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, cobalt chloride was positive in a micronucleus test and a chromosomal aberration test with mouse bone marrow cells (CICAD 69 (2006)). And cobalt was positive in a test in which oxidatively damaged DNA was investigated on the liver, kidney, and lung of rats (CICAD 69 (2006)). As for in vitro, this substance was positive in a bacterial reverse mutation test (CICAD 69 (2006), NTP DB (Access on August 2013)), and although it is not this substance, cobalt compounds and cobalt metal were reported to be positive in a chromosomal aberration test and a micronucleus test (CICAD 69 (2006)). From the above, although there are no in vivo data on this substance, cobalt chloride, the related substance of this substance, was positive in vivo, and cobalt compounds including this substance were positive as a whole also for in vitro. Therefore, it was classified in Category 2.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	This substance was classified in Category 2 because it is classified in Group 2B by IARC (IARC 86 (2006)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] As for data in experimental animals, information on reproductive effects of this substance itself is limited, and toxicity effects related to dosing of this substance are thought to be caused by cobalt ion after absorption in the body. Therefore, information on other water-soluble cobalt compounds was also used for this hazard class. As for effects in humans, it is reported that teratogenicity of cobalt chloride is not observed as written in (5). From (1), (3), (4), water-soluble cobalt compounds cause testicular toxicity and adverse effects on sperms in males and decrease the ability to impregnate females (fertilizing capacity). It is reported that fetotoxicity and teratogenicity occurred at doses where maternal animals did not show marked toxicity in rats and mice (2). From the above, for water-soluble cobalt compounds including this substance, in an oral route, adverse effects on the male genetic organs and decreased fertilizing capacity are reported, and it is reported that teratogenicity was shown at doses without maternal toxicity. Therefore, it was classified in Category 1B for this hazard class. [Evidence Data] (1) In a test in which mice were exposed to this substance by inhalation for 13 weeks, decreased sperm motility at or above 3 mg/m3 and decreased weight of the testis and epididymis, an increased ratio of abnormal sperms at 30 mg/m3 were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), NICNAS IMAP (Accessed Oct. 2018)). (2) As the result of dosing cobalt (II) sulfate (CAS: 10124-43-3) to pregnant rats by gavage through a gestation period, at the doses (25, 50 mg/kg/day) lower than 100 mg/kg/day where maternal animals showed slight effects (increases in relative weight of the liver, adrenal gland, and spleen), in addition to low values of fetal body weight, delayed development and increased malformations (malformations mainly in the cranium, spine, pelvis, renal tubule, ovary, and testis) in the skeletal system and viscera were observed. When pregnant mice were dosed with this substance at 50 mg/kg/day by gavage during the organogenesis period (gestation days 6-15), delayed development of the skeletal system and an increased incidence of malformations (mainly in the eyelid, kidney, cranium, and spine) were also observed in fetuses (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). (3) As the result of dosing male mice with cobalt (II) chloride (CAS: 7646-79-9) by drinking water for 12 weeks followed by mating with untreated females, decreases in the numbers of embryo resorptions and live fetuses at or above 200 ppm (25 mg/kg/day), decreases in the numbers of pregnant females and implantation sites at or above 400 ppm (47 mg/kg/day) were observed. Decreases in weight of the testis, epididymis and so on, a decreased number of sperms in the testis and epididymis, and decreased spermatogenesis were observed in males, and a decreased number of pregnant females is thought to be caused by decreased male fertility (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), NICNAS IMAP (Accessed Oct. 2018), Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). (4) As the result of dosing male mice with cobalt (II) chloride by drinking water at 72 mgCo/kg/day for 10 weeks followed by mating with untreated females, a decreased number of pregnant animals, a decreased number of live fetuses per litter, and an increased number of preimplantation losses per litter were observed in a dosed group. The results mentioned above are thought to be effects of decreased male fertility from decreased sperm concentrations. In a recovery group in which dosing males by drinking water was followed by mating and 6-week cessation of dosing, motility and movement speed of sperms became normal while concentrations did not (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). [Reference Data, etc.] (5) It is reported that teratogenicity is not observed in humans and that clinical changes were not observed in newborns from women who took cobalt chloride as an anti-anemia drug at delivery (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)). (6) It is classified in Repr. 1B in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (female reproductive organs)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	As a result of 13-week inhalation exposure to the aerosol of this substance in rats and mice at concentrations of 0.0003-0.03 mg/L, squamous metaplasia in the larynx in rats and mice from 0.0003 mg/L within the guidance value range for Category 1, inflammation in the lung in rats at or above 0.003 mg/L, and degeneration of the olfactory epithelium, etc. in the nasal cavity in rats and mice at or above 0.01 mg/L were observed. Furthermore, atrophy of the testis and decreased weights of the testis and epididymis were found in mice within the guidance value range for Category 2 (0.03 mg/L) (NTP TOX 5 (1991), CICAD 69 (2006)). From the above, it was classified in Category 1 (respiratory organs), Category 2 (male genitalia).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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