NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10102-43-9
Chemical Name	Nitrogen monoxide
Substance ID	m-nite-10102-43-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified	- -	-	-	It is not combustible (ICSC (J) (2015)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Category 1	Danger	H270	P370+P376 P220 P244 P403	Oxygen equivalency coefficient is 0.3 (ISO 10156:2010), and it is classified in Category 1 in GHS classification guidance for the Japanese government. Besides, compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1660).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Compressed gas	Warning	H280	P410+P403	It was classified as compressed gas from a boiling point of -151.74 deg C and a critical temperature of -92.9 deg C (HSDB (Access on August 2017)). Besides, compressed one is classified in Division 2.3, Subsidiary risk 5.1, 8 in UNRTDG (UN 1660).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	It is a gas according to the GHS definition. According to the GHS classification guidance for the Japanese government, the classification was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	It is a gas according to the GHS definition. According to the GHS classification guidance for the Japanese government, the classification was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	There were reports of LC50 values of 128 ppm and 854 ppm for rats (DFGOT (2014) (Access on August 2017)). However, these lacked descriptions of exposure time and could not be used as rationale. It was reported that 11 out of 20 animals died at 1,000 ppm (converted 4-hour equivalent value: 354 ppm) in a 30-minute single inhalation exposure test with rats (DFGOT (2014) (Access on August 2017)), suggesting that the LC50 value is in the vicinity of 354 ppm. Therefore, this substance was classified in Category 2. The data from RTECS (2004) used in the previous classification was not adopted this time because it could not be confirmed, and the details were unknown. By using a new information source, the category was changed from the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there was a description that skin irritation was caused by the formation of nitric acid and nitrous acid from this substance (HSDB (Access on August 2017)), and a description that nitric acid was formed from nitrogen oxides and sweat, and caused skin burns (IPCS, PIM 283 (1992)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there was a description that eye irritation was caused by the formation of nitric acid and nitrous acid from this substance (HSDB (Access on August 2017)), and a description that fumes of nitrogen oxides cause eye irritation (IPCS, PIM 283 (1992)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There was no in vivo data. As for in vitro, this substance was positive in bacterial reverse mutation tests and mammalian-cell gene mutation tests (DFGOT (2014) (Access on August 2017)). Besides, with regard to the information sources cited in the previous classification, IUCLID was unavailable at the time of the current classification, and RTECS is the information source listed in List 3, therefore, both of these sources were not used.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it was reported that no carcinogenicity was observed in the lung when female mice were exposed by inhalation to this substance at a concentration of 2.4 ppm for 29 months (DFGOT (2014)) (Access on August 2017). However, this is a result from a study that was conducted at one dose level only and in which histopathological examination was performed on a small number of organs only.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (blood system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	As for humans, it was reported that in a 15-minute single inhalation exposure test with volunteers, a significant increase in the blood methemoglobin concentration was observed at 15 ppm or above (DFGOT (2014) (Access on August 2017)). As for experimental animals, it was reported that blood methemoglobin concentrations were increased to 60% following a 6-hour exposure at 322 ppm (converted 4-hour equivalent value: 394 ppm) in a single inhalation exposure test with mice, and that the animals developed cyanosis, and 11 out of 20 animals died following a 30-minute exposure at 1,000 ppm (converted 4-hour equivalent value: 354 ppm) in a single inhalation exposure test with rats (DFGOT (2014) (Access on August 2017)). Although blood methemoglobin concentrations were not measured in the latter study (with rats), the authors of the source article considered that the occurrence of cyanosis is the effect of methemoglobin formation on the basis of findings from a separate study with rats in which blood methemoglobin concentrations were increased to 65% or more after a 30-minute exposure at 1000 ppm. From the above, this substance was classified in Category 1 (haemal system). Besides, it is described that this substance is converted spontaneously to nitrogen dioxide (NO2, CAS RN 10102-44-0) (ACGIH (7th, 2001)). In the previous classification, the lung was adopted as the target organ based on a description in the ACGIH (7th, 2001) that the symptoms of acute pulmonary edema and cyanosis due to methemoglobin formation occurred in humans due to exposure to this substance. However, close examination of the ACGIH (7th, 2001) revealed that it was a description that by inhaling, as an anesthetic, a gaseous mixture of 75% nitrous oxide (N2O, CAS RN 10024-97-2) and 25% oxygen contaminated with more than 1.5% of this substance, two patients suffered from dyspnea and pulmonary edema attributed to nitrogen dioxide in addition to cyanosis and methemoglobinemia. The effect on the lung was therefore not considered to be caused directly by this substance and was not adopted this time. Therefore, the classification was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There was no data showing the relationship between exposure to this substance alone and effects in humans. As for experimental animals, data were obtained from inhalation toxicity studies with rats, mice, rabbits, and dogs. However, while some of these data showed that an effect on respiratory tract irritation was observed at concentrations within the guidance value range for Category 2 (gas), others showed that no effect was observed (DFGOT (2014) (Access on August 2017)). Therefore, these data were not available for the classification. From the above, this substance was classified as "Classification not possible" due to a lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information