Item | Information |
---|---|
CAS RN | 102-77-2 |
Chemical Name | 2-(morpholinothio)benzothiazole |
Substance ID | m-nite-102-77-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Of four rat LD50 values documented (> 7940 mg/kg, > 5000 mg/kg, > 10000 mg/kg, and 1980 mg/kg (IUCLID (2000)), three values fall under the "Not classified" category and one value falls under Category 4. Giving precedence to the more represented category of two, the substance was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Since its rabbit LD50 is > 7940 mg/kg (IUCLID (2000)), the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Draize tests using rabbits found that a 24-hour application of the substance is not irritating (IUCLID (2000)). Other skin irritation tests using rabbits also discovered that the substance is not irritating (IUCLID (2000)). Based on these results, the substance was classified into the "Not classified" category. As additional information, skin irritation tests using guinea pigs found that the substance produced irritant reactions (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Draize tests using rabbits found that a 24-hour application of the substance is slightly irritating. Other rabbit tests also revealed that the substance is slightly to moderately irritating. Based on these results, the substance was classified into Category 2B. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Positive results have been obtained in both human patch tests (IUCLID (2000)) and guinea pig tests adopting Buehler's method (IUCLID (2000), HSDB (2003)). Thus, the substance was classified into Category 1. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Dominant lethal assays using rats (in vivo heritable mutagenicity tests using germ cells) found positive results (IUCLID (2000)); however, because only one dose was used in the assays and insufficient test information was provided, evaluation of the results was difficult. Regarding in vitro mutagenicity tests, Ames tests (IUCLID (2000)) and chromosomal aberration tests using CHO cells (HSDB (2003)) yielded negative results while mouse lymphoma assays gave positive results (IUCLID (2000)), and in mutation tests using CHO cells, both negative and positive results have been obtained (IUCLID (2000), HSDB (2003)). Overall, with an expert judgement, we could not validate the positive results obtained in in vivo tests (dominant lethal assays), and we could not reach definitive conclusions based on negative and positive results found in in-vitro tests. Thus, the substance was classified into the "Classification not possible" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Not classified |
- |
- | - | No signs of carcinogenicity were detected in the following tests: 2-year oral administration (mixed diet) tests using rats, 79-week forced oral administration tests using mice, 21-month oral administration (mixed diet) tests, and 18-month oral administration tests (IUCLID (2000)). Thus, the substance was classified into the "Not classified" category. In addition, no indication of tumorigenicity was detected in mice that received subcutaneous administration (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Not classified |
- |
- | - | In reproduction tests using female and male rats, no visible signs of poisoning, such as changes in the estrous cycle, delay in conceptions, and increased total embryonic mortality, were detected (IUCLID (2000)). In addition, in several oral administration tests conducted during the organogenetic period using rats, no adverse effects of administration such as incidences of fetal malformation and a decreased number of embryos due to post-implantation loss, were detected (IUCLID (2000)). Based on these results, the substance was classified into the "Not classified" category. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | No changes due to administration of the substance were detected, other than changes in organ weight, at the following doses in the following tests: an application of 1000 mg/kg in 4-week oral administration tests using rats (dose: 100, 200, 500, and 1000 mg/kg), an application of 1125 mg/kg in 3-month oral administration (mixed diet) tests (dose: 18, 69, 282, and 1125 mg/kg), an application of 1500 mg/kg in 21-month oral administration (mixed diet) tests (dose: 15, 150, and 1500 mg/kg), and an application of 125 and 250 mg/kg in 56-day forced oral administration tests (dose: 125, 250, and 500 mg/kg) (IUCLID (2000)). Since no effects of administration were detected within the range of guidance doses, the substance was classified into the "Not classified" category. Additionally, in 4-week inhalation exposure tests (6 hours/day and 5 days/week, dose: 0.0044, 0.0098, and 0.0102 mg/L), no pathological changes were observed, other than slight body weight reductions and changes in organ weights and biochemical values, at the highest dose tested (IUCLID (2000)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
Since its 96-hour LC50 = 1.3 mg/L for fish (Oncorhynchus mykiss) (IUCLID, 2004), the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Since its classification for acute toxicity is Category 2, and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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