NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	102-82-9
Chemical Name	Tributylamine
Substance ID	m-nite-102-82-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since the flash point by ICSC(2005) is 63degC(closed type), it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 210degC (ICSC,2005)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound not containing oxygen, fluorine or chlorine.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	LD50 value of the oral administration test employing a rat includes 540 mg/kg (Patty (5th, 2001) and 114 mg/kg (RTECS (2008)).). From LD50 value 540 mg/kg described in the information source of List1, it was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	From a description of LD50 value of 250 mu L/kg (equivalent: 195 mg/kg) (Patty (5th, 2001), RTECS (2006)) in the dermal administration test employing rabbits, it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It is written that mortality with 75 ppm of exposure level: 4/6 in 4-hour inhalation exposure test employing rats (Patty (5th, 2001), and LC50 value is considered to be <75 ppm. Since saturated vapor pressure level of this substance (25degC)is 122.89 ppm, it was classified into Category 1 by applying the gas standard.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	The irritation of Amines was evaluated as Grade 1-10 in the 24 hour skin irritation test with rabbits and this substance is presumed to be stimulating, because there is a description, "Grade 4" (Patty (5th, 2001)), although it is not a datum of 4-hour exposure. Moreover, since there are descriptions, "It has skin irritation" (Patty (5th, 2001, ICSC (2005)), "burns in the skin" and "stimulating" (HSDB (2002), it was classified in Category 2, although reversibility is not unknown.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is description that when Grade 1-10 estimates the irritation of amines in the eye irritation test employing rabbits, this substance shows "Grade 1: slight necrosis when 0.5 mLof non-diluted substance is instilled in the eye."(Patty (5th, 2001) effect), the level of irritation is unknown. Moreover, there is a description of "Almost all aliphatic Amins has eye irritation" (Patty (5th, 2001)), "It has serious influence and may cause dacryorrhea, conjunctivitis, and cornea dropsy," "It has irritation" (HSDB (2002)), and "It has a slight irritation."(ICSC (2005)). Although the level of irritation ranges from severe to mild, since this substance was a skin irritation substance, it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although there is a description that "skin sensitization is caused" (Patty (5th, 2001), HSDB (2002)), classification is not possible because of unknown details and insufficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the in vitro mutagenicity test (Ames test employing a Salmonella typhimurium) (NTP DB (Access on November 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified into Category 3 (Respiratory tract irritation) based on a description that "the lung irritation is deduced from decrease in a breathing rates" by the test which calculates RD50 value (50% breathing rates inhibitory concentrations) in inhalation exposures employing a mouse (HSDB (2002)). In addition, Patty (5th, 2001) has descriptions that aliphatic amines "showed very strong stimulus property and will stimulate mucosa and airway when steamy exposure of the animal is carried out by high concentrations", and that "a single dose in concentrations proximate for deaths causes tracheitis, bronchitis, pneumonia and lung edemas. "Moreover, the oral study on this article using the mammal (species unknown) has a description of "lethargy, agitation" (RTECS (2008)), and another description that "headache, nausea, vomit, dizziness, agitation and convulsion are caused" (HSFS (1999)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (central nervous system)	Warning	H373	P260 P314 P501	In the 19-day inhalation exposure test to male and female rats, "nasal irritation, disquiet, incoordination and trembling were observed" (Patty (5th, 2001), HSDB (2002)). Although these symptoms were observed within the limits of the guidance value of Category 1, it was classified into Category 2 (central nervous systems) since the OECD TG compliance and GLP were unknown. Moreover, although there is the description that "tracheitis, bronchitis, pneumonia and lung edema are caused by repeated inhalation exposure to sublethal concentration of aliphatic amines" (Patty (5th, 2001)), it is not adopted to categorize since the period and the concentration of exposure are unknown. In addition, "there are reports of central nervous system irritation" (Patty (5th, 2001) and (HSDB (2002)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 72-hour EC50 (biomass, pH not adjusted) = 3.6 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS: 2014).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (not readily degradable, an average degradation rate by BOD: 2% (J-CHECK, 1996)), and 72-hour EC10 (biomass, pH not adjusted) = 1.4 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS: 2014). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, an average degradation rate by BOD: 2% (J-CHECK, 1996)), and 48-hour EC50 = 8 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2014). From the above results, it was classified in Category 2.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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