NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10213-79-3
Chemical Name	Disodium silicate pentahydrate
Substance ID	m-nite-10213-79-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified	- -	-	-	Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Since it is reported that anhydrous form of this substance, sodium metasilicate (CAS No. 6834-92-0) is non flammable (SIDS (Access on May 2010)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although it contains a metal (Na), its water solubility is 610 mg/L (30 degC) (SIDS (Access on May. 2010)) and it is considered stable in contact with water.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an inorganic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen. Since no test results using designated methods for classification of oxidizing solids are available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the mouse LD50 value of 1200 - 1700 mg/kg (SIDS (Access on May 2010)), the substance was classified as Category 4. [Refer to sodium metasilicate (CAS: 6834-92-0) as the anhydrous form of this substance.]	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	The substance was classified as Category 1 based on the documented case of "corrosive" resulted from the rabbit test (OECD TG 404) in which dose of 0.5 g of test substance for 4 hours caused necrosis at application site, and symptoms did not disappear after 14 days, primary skin irritation index value was 7.8 - 8.0 (SIDS (Access on May 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified into Category 1 because its preexisting classification for skin corrosion/irritation is Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data were available. As relevant information, negative result was reported in the mouse local lymph node assay (OECD TG429) of anhydrous compounds. In humans, urticaria by contact to skin was observed in one case and ulcer formation and wheal were observed in patch tests for the same person (but not in 30 control subjects) (SIDS (Access on Dec. 2008)). However, details were not provided.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	No data are available in this substance. The substance was classified as "Not classified" based on the negative results in the chromosome aberration test using bone marrow of mice after oral administration with an anhydrous form of this substance (in vivo mutagenicity test in somatic cells) (SIDS (Access on Dec. 2008)). As relevant information, as for in vitro study, the negative results in the Ames test were reported (SIDS (Access on Dec. 2008)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available. As relevant information, no carcinogenicity were found in the oral administration tests for 14 months and 2 years to rats with anhydrous compound (SIDS (Access on Dec. 2008), IUCLID (2000)). However, there are no data using other animal species.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data were available. In the oral administration study using the anhydrous compound with pregnant mice during the organogenetic period, no developmental effects were observed (SIDS (Access on Dec. 2008)). However, there were no data on the effects on reproductive function, fertility of parent animals.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	No data were available for the substance itself, however, in the oral toxicity studies in rats using anhydrous compound (dose levels: 538 - 2000 mg/kg (males), 910 - 2600 mg/kg (females)), lethargy, increased breathing frequency, mydriasis and convulsion were observed (SIDS (Access on Dec. 2008)). In the oral toxicity study in mice (dose levels: 500 - 1920.8 mg/kg (males), 500 - 1372 mg/kg (females)), lethargy was also observed (SIDS (Access on Dec. 2008)). By converting the doses as equivalent doses to pentahydrate, those values that neurotoxic signs occurred were equivalent to those within Category 2 of the guidance values, therefore, the substance was classified as Category 2 (nervous system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In rats exposed to 500 pm of silicate (equivalent to 1259 mg/kg/day as sodium metasilicate, pentahydrate) for 8 weeks by feeding, it was reported that no other effects were seen except for reductions of concentrations in calcium and magnesium and decreased zinc concentration in liver (SIDS (Access on May 2010)). However, due to no description of histopathological findings and limited endpoints in addition to limitation of the study design (single dose with males only), "Classification not possible" was judged as relevant from the study. Otherwise, in the 3-month study of anhydrate in rats via drinking water (similar to OECD TG 408), the NOAEL was determined as 227 - 237 mg/kg/day based on no effects seen up to the highest dose (SIDS (Access on Dec. 2008)). It was also reported that in the 3-month study of anhydrate with mice via drinking water, no remarkable findings except for an increase in liver weight as well as a decrease in leukocyte count in females at the highest dose (ca. 600 mg/kg/day), and that the NOAEL was determined as 260 - 284 mg/kg/day (SIDS (Access on Dec. 2008)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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