Item | Information |
---|---|
CAS RN | 10233-03-1 |
Chemical Name | Magnesium hypochlorite |
Substance ID | m-nite-10233-03-1_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | It contains a metal (Mg), but the classification is not possible due to no data. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen and halogen, but the classification is not possible due to no data. Besides, barium hypochlorite, lithium hypochlorite, and calcium hypochlorite are classified in Category 2 according to the UN numbers in this hazard class. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] There are no data on this substance itself, but it was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) Because hypochlorite ion is alkaline, like calcium hypochlorite (CAS RN 7778-54-3), which is corrosive to the skin (AICIS (formerly, NICNAS IMAP) (2015)), this substance was also considered to be corrosive to the skin. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed based on new information. [Evidence Data] (1) This substance was classified in Category 1 in skin corrosion/irritation (GHS classification in 2020). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] There was no information on this substance itself, but since this substance was considered to dissociate into hypochlorite ions and magnesium ions in aqueous solution, classification was examined based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compounds. Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) As for in vivo of sodium hypochlorite (CAS RN 7681-52-9), in a micronucleus test using the bone marrow of mice dosed by intraperitoneal injection or oral administration, negative results were reported; in a mammalian bone marrow chromosomal aberration test with mice dosed by oral administration, negative results were reported; and in a DNA damage test with rats dosed by oral administration, negative results were reported (EURAR (2007), NTP TR392 (1992), Patty (6th, 2012)). (2) As for in vitro of sodium hypochlorite, in a bacterial reverse mutation test, and a mammalian cell chromosome aberration test, negative and positive results were reported (EURAR (2007), NTP TR392 (1992)), and in a sister chromatid exchange test, positive results were reported (EURAR (2007)). (3) As for in vivo of magnesium chloride (CAS RN 7786-30-3), in a micronucleus test using the bone marrow of mice dosed by intraperitoneal injection, negative results were reported (SIAR (2011)). (4) As for in vitro of magnesium chloride, in a bacterial reverse mutation test, and a mammalian cell chromosome aberration test, negative results were reported (SIAR (2011)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] No data available. [Reference Data, etc.] (1) The IARC classified hypochlorites in Group 3 (IARC 52 (1991)), although this substance was not included. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no data on this substance, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in an aqueous solution, classification was examined based on the data of hypochlorous acid (CAS RN 7790-92-3) and water-soluble magnesium. As for hypochlorous acid, it was considered that there were generally no reproductive effects, but since there was no data of developmental toxicity at the administration only during the organogenesis period, it was determined that classification was not possible due to lack of data. As for magnesium ions, there were data in (4), and no reproductive effects were observed, but since the test was a screening test, and there was no data of developmental toxicity in the case of administration during the organogenesis period only, classification was not possible due to lack of data. From the above, classification was not possible due to lack of data. [Evidence Data] (1) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, alterations in body weight, sperm count, sperm motility or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-dependent effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (2) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) It was stated as follows in the EURAR (2007). There was no data on sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that although limited data was available, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. Similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). (4) As for reproductive effects of magnesium salt, the information on magnesium chloride (CAS RN 7786-30-3) was obtained. In a reproduction/developmental toxicity screening test (OECD TG 421) by oral administration of magnesium chloride to rats dosed by gavage, no reproductive effects or developmental effects were observed at the highest dose (1,000 mg/kg/day) at which toxicity in parent animals (soft stool, diarrhea, salivation, decreased body weight gain) was observed (SIAR (2011)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] There was no information on this substance itself, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compound. Based on (1) and (2), it was classified in Category 3 (respiratory tract irritation). Effects on the gastrointestinal system were not adopted because they were considered to be attributable to irritation by sodium hypochlorite. [Evidence Data] (1) In humans exposed to drugs containing sodium hypochlorite (CAS RN 7681-52-9), eye and upper respiratory tract irritations were observed (EURAR (2007)). (2) Accidental ingestion of a small amount of chlorine bleach containing sodium hypochlorite could cause esophageal irritation, and in high concentration, it could cause severe damage to the upper respiratory tract and even death (AICIS (previous NICNAS) IMAP (2014)). [Reference Data, etc.] (3) A 66-year-old woman who accidentally ingested chlorine bleach containing sodium hypochlorite (unknown quantity) died of cardiac arrest in 4.5 hours, and autopsy revealed esophageal and gastric mucosal erosions, perforations at the gastro-esophageal junction, and extensive necrosis of adjacent soft tissue (AICIS (previous NICNAS) IMAP (2014)). (4) In a child who accidentally ingested bleach containing sodium hypochlorite and swallowed small amounts, discomfort and vomiting by stomach irritation were observed (IPCS PIM 495 (1998)). (5) Gastrointestinal irritation with emesis and vomiting occurred with accidental ingestion of sodium hypochlorite, and corrosive injury of the stomach and hypernatremia with hyperchloremic acidosis occurred with ingestion of a large amount of sodium hypochlorite (IPCS PIM 495 (1998)). (6) Chlorine gas released from sodium hypochlorite caused burning in the throat and coughing. High levels of exposure could lead to swelling and obstruction of the airway, and in serious cases, noncardiogenic pulmonary edema could occur (IPCS PIM 495 (1998)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no information on this substance itself, but since it was considered that this substance dissociated into hypochlorite ions and magnesium ions in aqueous solution, examination was carried out based on the information on sodium hypochlorite (CAS RN 7681-52-9) and soluble magnesium compound. Based on (1) and (2), it was considered that repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was low, but since effects on the respiratory organs due to inhalation exposure were unknown, it was determined that classification was not possible. [Reference Data, etc.] (1) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only reduced body weight gain which was considered to be associated with reduced water consumption, was observed when rats and mice were dosed for 90 days and 2 years (EURAR (2007), SIAR (2006)). (2) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 8 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)). (3) As for magnesium chloride (CAS RN 7786-30-3), it was reported that in a reproduction/developmental toxicity screening test with rats (dosed by gavage for 42 days for males and 14 days for females), at 500 mg/kg/day (converted guidance value: males/females: 233/78 mg/kg/day, exceeding Category 2 for males, and within the range for Category 2 for females), soft stool, diarrhea, and salivation were observed (SIAR (2011)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | - |
- |
- | - | - | - | - |
11 | Hazardous to the aquatic environment Long term (Chronic) | - |
- |
- | - | - | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|