NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10294-34-5
Chemical Name	Boron trichloride
Substance ID	m-nite-10294-34-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (Hommel (1991)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified	- -	-	-	It was classified as "Not classified" because it is classified in Division 2.3, Subsidiary Risk 8 in UNRTDG (UN1741), not Subsidiary Risk 5.1.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	It was classified as low-pressure liquefied gases from information: a critical temperature of 178.8 deg C (Hommel (1991)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to gas substances are not available.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition). It was classified as "Not classified."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3. [Evidence Data] (1) LC50 (1 hour) for rats: male: 2,541 ppm (converted 4-hour equivalent value: 1270.5 ppm), female: 21.1 g/m3 (4,403.3 ppm) (converted 4-hour equivalent value: 2,201.7 ppm) (HSDB (Access on July 2019))	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)."	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) This substance, through its conversion to hydrogen chloride on contact with water, is highly irritating to the mucous membranes and skin via direct contact (ACGIH (7th, 2016)). (2) This substance is extremely irritating or corrosive to the skin and eyes, and the liquefied gas may cause burns (HSDB (Access on July 2019)). [Reference Data, etc.] (3) It was classified as "Skin Corr. 1B (H314)" in the EU-CLP classification (EU CLP classification (Access on July 2019)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1. [Evidence Data] (1) This substance, through its conversion to hydrogen chloride on contact with water, is highly irritating to the mucous membranes and skin via direct contact (ACGIH (7th, 2016)). (2) This substance is extremely irritating or corrosive to the skin and eyes, and the liquefied gas may cause burns (HSDB (Access on July 2019)). (3) This substance was classified as Skin corrosive substance (Category 1).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There is no information on the reproductive toxicity of this substance itself. However, information on boric acid (CAS RN 10043-35-3) and borax (Na2B4O7 10 H2O, CAS RN 1303-96-4) is considered to be available as boron compounds. Based on (1)-(3), it was classified in Category 1B. [Evidence Data] (1) In reproductive toxicity tests in which mice were given boric acid by feeding or rats were given boric acid or borax by feeding, infertility due to decreased fertility was observed at doses where no general toxic effects were observed in parental animals. As a result of cross-breeding tests, decreased fertility in males was the cause of infertility in mice, whereas complete infertility was also observed in rats when treated females were mated with control males (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2010)). (2) In multiple developmental toxicity tests in which pregnant rats or mice were administered boric acid by feeding during the organogenesis period, an increased incidence of malformations (agenesis or shortening of the 13th rib, dilatation of the lateral ventricles, etc.), increased fetal mortality and neonatal mortality were observed at doses where maternal toxicity (reduced body weight gain, decreased food consumption, etc.) was manifested (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2010)). (3) In a test in which pregnant rabbits were administered boric acid by gavage during the organogenesis period, an increase in cardiovascular malformations and increased fetal mortality were reported at a dose where decreased body weight was observed in maternal animals (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] There are no reports on the single exposure to this substance in humans and experimental animals. However, based on (1) and (2), it was classified in Category 1 (respiratory organs). [Evidence Data] (1) Since this substance is rapidly hydrolyzed by contact with water to form hydrochloric acid (CAS RN 7647-01-0), it is highly irritating to the skin, mucous membranes and respiratory tract (ACGIH (7th, 2016)). (2) There are descriptions that chemical pneumonia and pulmonary edema may occur as effects on the respiratory organs by acute inhalation exposure to this substance (HSDB (Access on July 2019)). [Reference Data, etc.] (3) In a study in which rats, mice and guinea pigs were exposed by inhalation at 20, 50 or 100 ppm of this substance for 7 hours/day for 2 days conducted in the 1950s, when the cages were cleaned or changed every 2 hours, all the rats survived at 100 ppm, but all the guinea pigs and 93% of the mice (number of animals not stated) died, and widespread inflammation of the lung and interstitial pneumonia were observed in the dead animals. However, if the cage was not cleaned and changed, all species showed high mortality at all concentrations. It was stated that the cause could be due to animals' licking the substance attached to their skin or paws. It was also described that the feet and mouth of the animals were grossly swollen (ACGIH (7th, 2016)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) This substance is rapidly hydrolyzed to form hydrochloric acid and causes burns to the respiratory tract, skin and eyes (ACGIH (7th, 2016)). (2) Only TLV-C (Ceiling) was set based on respiratory tract irritation and pneumonia (ACGIH (7th, 2016)).	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Gas (GHS definition)	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2019	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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