Item | Information |
---|---|
CAS RN | 103-95-7 |
Chemical Name | 3-p-cumenyl-2-methylpropionaldehyde |
Substance ID | m-nite-103-95-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
A flash point was 79.5 deg C (closed-cup) (GESTIS (Accessed June 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 240 deg C (ECHA (Accessed June 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" (Category 5 in UN GHS classification) from (1). [Evidence Data] (1) LD50 for rats: 3,810 mg/kg (JECFA (2004), REACH registration dossier (Accessed May 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (REACH registration dossier (Accessed May 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
[Rationale for the Classification] It was classified in Category 2 from (1), (2). [Evidence Data] (1) It is reported that in a skin irritation test with rabbits (n = 3) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was observed (erythema/eschar score: 2.7/2/2, edema score: 3/3/2.7) (REACH registration dossier (Accessed May 2020)). (2) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was seen (erythema/eschar score: 2/2/2/2.7, edema score: 2.7/2.7/2.3/3) (REACH registration dossier (Accessed May 2020)). [Reference Data, etc.] (3) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was found (erythema/eschar score: 2/2/2/2, edema score: 2.3/2.7/2/1.7) (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 6) (7-day observation), no eye irritation was seen (corneal opacity score: 0/0.7/0.3/0/0.7/0, iritis score: 0.3/0.3/0/0.3/0.3/0.3, conjunctival redness score: 1.3/1/1.3/0.3/0.7/1, chemosis score: 0/0.3/0/0/0.7/0) (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Category 1B |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] It was classified in Category 1B from (1). [Evidence Data] (1) It is reported that in a local lymph node assay (LLNA) with mice (n = 4) (OECD TG 429), irritation index (SI values) was 1 (0%), 1.4 (1%), 1.34 (2.5%), 1.84 (10%), 3.26 (25%), 5.16 (50%), the EC3 value was calculated as 22.3%, and it was weakly senstizing (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Since there was no in vivo data available, classification was not possible due to lack of data. [Evidence Data] (1) In an in vitro mammalian cell (CHL) chromosome aberration test, negative results were reported (JECDB (Accessed May 2020)). (2) In a bacterial reverse mutation test (OECD TG471 & EU Method B. 13/14, GLP), negative results were reported (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] In (1), at the dose at which general toxicity appeared in parental animals, significant male infertility due to effects on the testes or sperms in parental male rats and increased incidences of the eye lesions in pups were observed. Since reproduction toxicity effects were observed at the dose at which general toxicity appeared in parental rats, it was classified as Category 1B with consideration given to the significance of the effects. [Evidence Data] (1) It was reported that in a one-generation reproduction toxicity study with rats dosed by gavage (OECD TG415, GLP, beginning 83 days prior to cohabitation, through cohabitation, continuing through the day before sacrifice (males), beginning 14 days before cohabitation, through cohabitation and gestation, to day 22 postpartum (females)), at 150 mg/kg/day, reduced body weight gains, an increase in liver weight, and findings on the adrenal glands were observed in parental animals, no occurrence of pregnancy following mating between treated male rats and untreated female rats (pregnancy occurred: 1 of 24 cases), masses on the cauda epididymis (sperm granulomas), an increase in epididymal weight, reduced sperm motility from sperm taken from the vas deferens (all rats) (due to the presence of drifting debris, headless sperm, detached heads, and/or less than the required number of sperm for evaluation), an increased number of litters having pups with a lenticular opacity (20 of 24 litters), lenticular opacities (first observed on day 16 and persisted until day 22 postpartum), an increased number of male and female rats with a lenticular opacity during the postweaning period, and a significant reduction in the anogenital distance of male pups at weaning were observed (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Evidence Data] (1) It was reported that in a 14-day oral administration test with rabbits dosed by gavage, at 300 mg/kg/day (converted guidance value: 46.7 mg/kg/day, within the range for Category 2), no changes in body weight, food consumption, clinical findings, and the weight of any reproductive or non-reproductive organs were observed. Also, it was reported that there were no histopathological findings in the testes or epididymis and no changes in sperm parameters (REACH registration dossier (Accessed May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 48-hour EC50 = 1.4 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
It was classified in Category 2 because it is not rapidly degradable (BIOWIN) and due to 21-day NOEC = 0.71 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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