NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10325-94-7
Chemical Name	Cadmium nitrate
Substance ID	m-nite-10325-94-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is nitrates and contains chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is nitrates and contains chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is considered to be stable against water since data are available that water solubility is 156 g/100 g (25 degC) (Lide (88th, 2008)) through it contains metals (Cd).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is inorganic compound containing oxygen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Not organic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on a LD50 value of 100 mg/kg for mice (EHC 134 (1992)), the substance was classified into Category 3. There is a report of a LD50 value of 300 mg/kg for rats on HSDB (2005) in List 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Because in vivo data on this substance itself available for the classification were not obtained, information on the whole cadmium compounds (as cadmium ion, Cd2+) was used for evaluation. From (1), (2), positive reports in germ cells and somatic cells were obtained on water-soluble cadmium chloride. Because this substance is also water soluble, it is thought to have hazards similar to cadmium chloride and was classified in Category 1B. The category was revised by considering knowledge on the whole cadmium compounds and water solubility of this substance. [Evidence Data] (1) It is reported that after administration of cadmium (mainly cadmium chloride), chromosomal aberrations in mouse spermatocytes and hamster oocytes and altered gene expression in mouse spermatid occurred (ATSDR (2012), IARC 58 (1993)). (2) It is reported that as the result of administrating cadmium chloride to mice, dose-dependent increases in the incidences of micronuclei, sister chromatid exchanges, and chromosomal aberrations were observed in the peripheral blood. Moreover, it is reported that increased single strand breaks in the DNA were observed in rats after administrating cadmium chloride (EU-RAR (2007), DFGOT Vol. 22 (2006), NICNAS IMAP (Accessed Dec. 2018)). [Reference Data, etc.] (3) It is reported that increases in the incidences of micronuclei and sister chromatid exchanges in peripheral lymphocytes were shown in workers occupationally exposed to cadmium (compound not specified) and that human lymphocytes from people inhabiting cadmium-polluted areas of China were found to have increased micronuclei rates and a higher frequency of chromosomal aberrations and severe aberration types. However, conflicting knowledge is also reported (ATSDR (2012)). (4) As for in vivo, a dominant lethal test by administrating cadmium (mainly cadmium chloride) was negative (ATSDR (2012), IARC 58 (1993), DFGOT Vol. 22 (2006)). (5) As for in vitro, it is reported that a bacterial reverse mutation test, a chromosomal aberration test and a sister chromatid exchange test in cultured mammalian cells (CHO) were positive (NICNAS IMAP (Accessed Jan. 2019)). (6) Water solubility of this substance is 1,560 g/L (HSDB (2012)). (7) This substance was classified in Muta. 1B in EU CLP.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Since cadmium and cadmium compounds are classified into "Group 1" in IARC (IARC 58 (1993)), "K" in NTP (NTP Roc (11th, 2004)), and into Category 1 in Japan Society For Occupational Health (JSOH), the substance was classified into Category 1A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There are no available data for the substance. However, for cadmium chloride, a representative cadmium compound, developmental toxicity is suggested. Therefore, the substance was classified into Category 2 since the possibility of developmental toxicity of the substance cannot be ruled out. Refer also to cadmium chloride (CAS: 10108-64-2).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, gastrointestinal system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	No data for the substance is available. However, as acute effects of cadmium compounds to humans, "chemical pneumonitis and oedema after inhalation exposure, and rapid onset with severe nausea, vomiting and abdominal pain after ingestion" are characteristic symptoms (EHC 134 (1992)). Based on the data, the substance was classified into Category 1 (respiratory system, alimentary system)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, kidney, bone)	Danger	H372	P260 P264 P270 P314 P501	No data for the substance is available. However, as chronic effects of cadmium compounds to humans, "emphysema, renal dysfunction such as glomerular proteinuria, and which induced hypercalciuria, disturbances in rate of calcium to phosphate, hypophosphataemia, formation of renal stones, osteomalacia and osteoporosis" are characteristic (EHC 134 (1992)). Based on the information, the substance was classified into Category 1 (respiratory system, kidney, bone).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 72h-ErC50 = 0.12 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2000).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water is unknown from which it is a metal compound.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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