Item | Information |
---|---|
CAS RN | 10326-41-7,50-21-5,598-82-3,79-33-4 |
Chemical Name | Lactic acid (DL-, L-, D-) |
Substance ID | m-nite-10326-41-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point of 110 deg C [closed-cup] (ICSC (1997)) is above 93 deg C. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,730 mg/kg for rats (JECFA 344 (1974)). Besides, this substance is an isomer mixture of L-lactic acid (CAS 79-33-4) and D-lactic acid (CAS 10326-41-7), and information on the L-isomer was also described in some hazard class. |
FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. Besides, for the L-isomer, there is a report on an LD50 value of > 2,000 mg/kg for rabbits (SIDS (2008)), corresponding to "Not classified." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. Besides, for the L-isomer, there is a report on an LD50 value by 4-hour exposure (aerosol) of > 7.94 mg/L for rats (SIDS (2008)), corresponding to "Not classified." | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It was classified in Category 1 because it is described that the pH of this substance was about 1.2 (USEPA/HPV (2002), corresponding to List 1). Besides, it is reported that it was not irritating in a test in which sodium hydroxide was added to this substance (80%) as a buffer and was applied to rabbits (OECD TG 402, GLP) (USEPA/HPV (2002)), and it was corrosive in a test in which the L-isomer of this substance (88%) was applied to rabbits (OECD TG 402, GLP) (USEPA/HPV (2002)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
It was classified in Category 1 because it is described that the pH of this substance was about 1.2 (USEPA/HPV (2002)), and in a test in which 750 microg of this substance was applied to the rabbit eye, the severity of damage was 8 on a scale from 1 to 10 (10 being the most severe) and severe (RTECS (2010): the original article, American Journal of Ophthalmology: 29, 1363, 1946). Besides, it was also classified as a corrosive substance in skin corrosion/irritation. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Not classified |
- |
- | - | It was classified as "Not classified" because it was concluded that it was not sensitizing in a maximization test with guinea pigs (USEPA/HPV (2002), HSDB (2006)). Besides, also for the L-isomer of this substance, it is reported that it was not sensitizing in a Buehler test with guinea pigs (EPA OPP 81-6, GLP) (USEPA/HPV (2002)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was negative in an Ames test (NTP DB ID: A10575 (1997)), positive in a chromosomal aberration test (pseudo-positive due to low pH) (Mutat Res., 240, 195-202, (1990)), and negative in a chromosomal aberration test with CHO cells (SIDS (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. Besides, it is reported for calcium lactate that there was no evidence of carcinogenicity in a 2-year drinking water administration test with rats (SIDS (2008)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Data are lacking. Besides, it is described that there were no effects on maternal animals or the development of offspring in a test by oral administration of 570 mg/kg/day to pregnant mice during the organogenesis period (SIDS (2008)), but the details are unknown, and effects on sexual function and fertility are unknown. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | It is reported that after oral administration to rats, one out of five animals at 650 mg/kg and two out of five animals at 1,300 mg/kg died within 24 hours, and after re-administration of the same amounts to surviving animals after eight days, two in the 1,300 mg/kg group showed dyspnea, snivel, vomiting, and abdominal inflation and died (HSDB (2006)). However, because the further details are unknown, it was classified as "Classification not possible." Besides, in an acute oral toxicity test on the L-isomer (LD50 value: 3,543-4,936 mg/kg), symptoms such as lethargy, ataxia, prostration, and irregular breathing were observed (USEPA/HPV (2002)). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is reported that no effects on general symptoms, body weight, etc. were observed in a 90-day oral administration test with rats or a test by 14-week administration by feeding or drinking water to hamsters (USEPA/HPV (2002)), but the details such as accurate doses are unknown, and it is reported that there were no adverse effects after 2.5-month oral administration of 600-1,600 mg/kg to dogs (JECFA 344 (1974)). And it is reported that weights of the brain and kidney increased after 13-week dermal administration of 886 mg/kg to rats, but no lesions were found at visual and microscopic examination (USEPA/HPV (2002)). However, because the test details are unknown in either test, it was classified as "Classification not possible" due to lack of data. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 96-hour LC50 = 130 mg/L for fish (Lepomis macrochirus) (SIDS, 2011). | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (ready biodegradable, BOD: 76% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and it was classified as "Not classified" in acute toxicity. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2012 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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