Item | Information |
---|---|
CAS RN | 104-76-7 |
Chemical Name | 2-Ethyl-1-hexanol |
Substance ID | m-nite-104-76-7_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
It was classified in Category 4 from a flash point of 73 deg C (closed-cup) (GESTIS (Access on December (2013))). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 231 deg C (HSDB (Access on December (2013))). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | There are reports on six LD50 values for rats of 2,053 mg/kg, 3,200 mg/kg, 3,250 mg/kg, 3,730 mg/kg, 3,200-6,400 mg/kg, and 2,049-7,000 mg/kg (JECFA FAS32 (1993), DFGOT vol. 20 (2003), PATTY (6th, 2012)), and it was classified as "Not classified" (Category 5 in UN GHS classification) to which four of them corresponded. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There are reports on LD50 values for rats of > 2,000 mg/kg and > 3,000 mg/kg (DFGOT vol. 20 (2003)) and LD50 values for rabbits of 1,986 mg/kg, > 2,000 mg/kg, and > 2,600 mg/kg (JECFA FAS32 (1993), DFGOT vol. 20 (2003), PATTY (6th, 2012)), and it was classified as "Not classified" to which most data corresponded. Data in JECFA FAS32 (1993) and PATTY (6th, 2012) were added, and the category was reviewed. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that there were no deaths in vapour inhalation tests with rats, at 0.89 mg/L (4 hours) (DFGOT vol. 20 (2003), IUCLID (2000)), or by exposure to the saturated vapour (0.953 mg/L) (8 hours) (converted 4-hour equivalent value: 1.35 mg/L) (JECFA FAS32 (1993), PATTY (6th, 2012)), but the classification is not possible because these data did not enable determining to which category an LC50 value corresponded. Besides, because the above values were higher than 90% of the saturated vapour pressure concentration of 0.953 mg/L, a reference value in the unit of mg/L was applied as a vapour with mist. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that there were no death cases at 1.2 mg/L (6 hours) (converted 4-hour equivalent value: 1.8 mg/L) (JECFA FAS32 (1993), DFGOT vol. 20 (2003), PATTY (6th, 2012)), and all animals died at 5.3 mg/L (a mixture of aerosol/vapour) (4 hours) (DFGOT vol. 20 (2003), IUCLID (2000)), but the classification is not possible because these data did not enable determining to which category an LC50 value corresponded. Besides, because the above values were higher than the saturated vapour pressure concentration of 0.953 mg/L, a reference value in the unit of mg/L was applied as mist. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It is reported in DFGOT vol. 20 (2003) that in a test (OECD TG 404) in which the undiluted test substance was applied to rabbit skin for 4 hours, there was severe irritation with reddening, edema, and scar formation, and the skin irritation score was 6.75/8.0, and that slight reddening and edema formation after 24 hours and marked peeling after eight days were observed in a 20-hour occlusive exposure test with rabbits. It was classified in Category 2 based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
It is reported in DFGOT vol. 20 (2003) that in a test in which 0.1 mL of the undiluted test substance was applied to rabbit eyes (OECD TG 405), there was moderate to severe irritation of the cornea, iris, and conjunctiva, and the eye irritation score was 28.59/110. And it is reported in ECETOC TR48 (1998) that in a test in which 0.1 mL of the undiluted test substance was applied to the conjunctival sac of rabbit eyes, corneal opacity, iritis, and redness and chemosis in the conjunctiva were observed after 24 hours, the eye irritation score (MMAS) was 51.3/110, and these disappeared after 7-14 days. It was classified in Category 2A based on the above information. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that in a skin sensitization test in 29 volunteers by the Kligman method (a maximization test), no one showed sensitization reactions, and it is described that the occupational medicine department of a manufacturing and processing company reported that this substance was not a skin sensitizer (DFGOT vol. 20 (2003)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a dominant lethal test with mice and negative in a micronucleus test with mouse bone marrow cells and a chromosomal aberration test with rat bone marrow cells (DFGOT vol. 20 (2003)). As for in vitro, it was negative in all of a bacterial reverse mutation test, an hprt gene mutation test, a mouse lymphoma test, and a chromosomal aberration test with cultured mammalian cells (DFGOT vol. 20 (2003), IUCLID (2000), JECFA (1998), NTP DB (Access on September 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
After oral administration to rats on day 12 of gestation, there was no report on maternal toxicity, but an increased incidence of malformed fetuses such as hydronephrosis, tail anomalies, and malformed limbs was observed (DFGOT vol. 20 (2003)). Furthermore, in a developmental toxicity test by oral administration during the organogenesis period of rats, an increase in skeletal malformations was found in addition to clear increases in resorptions and post-implantation losses and an increase in fetuses with dilatation of the renal pelvis and hydroureter at the dose where maternal animals showed deaths, general symptoms, decreased food consumption, and reduced weight gain. And it is concluded that this substance was teratogenic only at doses that caused maternal embryo/fetotoxicity (DFGOT vol. 20 (2003)). Therefore, it was classified in Category 2. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory organs), Category 3 (narcotic effects) |
Warning |
H371 H336 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
It is reported that occupational exposure to this substance causes headaches, dizziness, fatigue, intestinal disorders, and a slight decrease in blood pressure in humans (PATTY (6th, 2012)). In animals tests, it is reported that in a single inhalation administration test with mice, rats, and guinea pigs (1.8 mg/L/4 hours, mist (converted from exposure to 227 ppm for 6 hours)), lung hemorrhage, reversible central nervous system depression, and irritation of the mucous membranes of the eyes, nose, throat, and respiratory passages were observed (JECFA FAS32 (1993), DFGOT vol. 20 (2003)). Therefore, it was classified in Category 2 (respiratory system), Category 3 (narcotic effects, respiratory tract irritation). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | From descriptions in DFGOT vol. 20 (2003), PATTY (6th, 2012), and JECFA FAS 32 (1996), no toxicity effects were seen at the doses within the range for Category 1-2 in any of 13-week or 2-year gavage administration or 13-week diet administration tests with rats, and an 18-month gavage administration test with mice, and effects on the liver (increased weights, peroxisome proliferation, etc.), kidney (cortical degeneration), and forestomach (hyperplasia of the epithelium) were observed at the doses above the range for Category 2. On the other hand, in a 90-day inhalation test with rats exposed to the vapour of this substance, no toxicity effects were found at up to the highest concentration (120 ppm; 0.65 mg/L), but the test concentrations did not cover the guidance value range for Category 2, toxicity effects at the upper limit of the guidance values are unknown, therefore it was judged as insufficient data to use for the classification. And there are no data on dermal exposure available for classification. From the above, it corresponds to "Not classified" in the oral route. However, because of insufficient toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data as a whole. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
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