NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10453-86-8
Chemical Name	(5-Benzyl-3-furyl)methyl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
Substance ID	m-nite-10453-86-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.3349(ICSC, 2001)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the unsaturated bond is included, it was classified into Not classified, since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.3349(ICSC, 2001).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.3349(ICSC, 2001)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a description that LD50 values of the oral administration test employing a rat are >5,000 mg/kg, 1,987 mg/kg, 960 mg/kg (EHC 92 (1989)), >2,500 mg/kg, 1,721 mg/kg, 1,244 mg/kg (EHC 92 (1989), HSDB (2001)), and 1,400 mg/kg (HSDB (2001)). Since all definite values corresponded to Category 4, it was classified into Category 4. In addition, in EU classification, it is Xn; R22 (EU-Annex I).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since LD50 value of the dermal administration test employing rats was >2,500 mg/kg (EHC 92 (1989)) and >3,000 mg/kg (HSDB (2001)), and LD50 value of the dermal administration test employing rabbits was >2,500 mg/kg (EHC 92 (1989)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It is written that LC50 value of 4-hour aerosol inhalation exposure test employing rats is >9.49 mg/L, and LC50 value of 1-hour aerosol inhalation exposure test employing rats is >12.0 mg/L (4-hour equivalent: >4.9 mg/L) (EHC 92 (1989)). Since LC50 value was >9.49 mg/L, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	Although there is a description, "irritates the skin" in the section of Effects of Short Term Exposure in ICSC (2001), "slight irritant" is described for the skin irritation test using Resmethrin rabbits' ears in EHC 92 (1989) that is the information source for List 1. In addition, there is a description, "There is no skin irritation" (EHC 92 (1989, JMPR (1991))) in the skin irritation test using Bioresmethrin rabbits' ears that are the component of this substance. The "slight irritant" is deemed to correspond to GHS Skin irritation Category 3, but classified into "Not classified", because it is a division not domestically adopted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Although in the section of the effects of short-term exposure of ICSC (2001), there is a description of "An eye is stimulated," details, such as the level of the stimulus are unknown. Although there is a description of "There is no eyes irritation." in the eye irritation test employing a rabbit (EHC 92 (1989), JMPR (1991)) for Bioresmethrin which is a component of this substance, since there is no data of this substance, classification is not possible due to insufficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	There is a description that "guinea pig did not indicate skin sensitizations" (EHC 92 (1989)). Moreover, for Bioresmethrin which is a component of this substance, although there are descriptions that "skin sensitization was not shown" (JMPR (1991)) and that "a potential sensitization is low only with slight erythema" (EHC 92 (1989), JMPR (1991)) in the sensitization tests with guinea pig, the substance cannot be classified because of insufficient data since it has no other data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the reverse mutation test employing Salmonella typhimurium and bacillus coli, chromosome aberration test employing a Chinese hamster cultured cell and mouse bone marrow cells, and the mutation assay employing Chinese hamster V79 cell as in vitro mutagenicity tests (EHC 92 (1989)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, there is a description that "carcinogenicity was not foreseen by highest dose, either" in the 85-week oral administration study employing mice and the 112-week oral administration study employing rats (EHC 92 (1989)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is a description as follows in NTP DB (Access on November 2008), "There is no reproductive toxicity against animals but data are not available for humans." Moreover, there is a description as follows in EHC 92 (1989), "Teratogenicity was not observed" in the teratogenicity study via oral administration using rats and mice. On the other hand, there is a description as follows in the 3 generation study with mixed food administration using rats, " Statistically apparent increase in the number of low body weight children and still birth was observed"(EHC 92 (1990), IRIS (2002)) but it was classified in Category 2, because the effect of toxicity on parent animals at the same dose level is unknown without reviewing primary documents.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There is a description that the animal exposed to Resmethrin "shows nerve tremor, excitement, convulsive muscle contraction, collapse, and coma" as acute symptoms (EHC 92 (1989)). Moreover, when the cited literature of the test data described in HSDB (2001) (Environ.Health Perspect.14 (1976)) was investigated, there were descriptions of "Nerve tremor and ataxia were seen 30 minutes to 3 hours after exposure, sensitive reaction in the oral administration test employing rats and mice of Resmethrin and of "Ataxia and incontinence of urine were seen at the time of high concentration exposure." in 4 hours mist inhalation exposure test for employing rats and mice of , (+)-Trans & Cis-reaction." This substance consists of four sorts of isomer mixtures. In consideration of the degree of the toxicity varying depending on compounding ratio, the central nervous system was considered to be the target organ from these findings. Moreover, since the effect was seen within the range of the guidance value of Category 2, it was classified into Category 2 (central nervous system). In addition, the section of the effect of short term exposures in ICSC (2002) has a description of "The nervous system may be affected" for Cis-resmethrin which is one of the composition ingredients of this substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (central nervous system)	Warning	H373	P260 P314 P501	It is written in carcinogenicity examination by 2-year oral administration in rats that"hypertrophy of hepatocytes and decrease in lien weight of female rats were found" (IRIS (2002)). Moreover, it is written in EHC 92 (1989) that in 90- day inhalation exposure test in rats that "minute clinical findings and irritating property findings were found in level of exposure 0.3 mg/L, however, histopathology findings by administration were not found in lungs or other organs, and in 112-week oral study in rats that "hypertrophy of hepatocytes was found, however, it was not classified into specific virulence response". In addition, "weight reduction, feed intake reduction, increase in liver weight, and tremulousness were described as common findings in the oral study in a number of rats, it was classified into Category 2 (central nervous systems) because tremor symptoms were found within the scope of the guidance value of Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96 hours LC50=0.000275mg/L of the fish (Rainbow Trout) (EHC 92 (1989)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: -4% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (2007))), it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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