NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10486-00-7
Chemical Name	Sodium perborate tetrahydrate
Substance ID	m-nite-10486-00-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	No data are available though there are chemical groups (-O-O-) associated with explosive properties present in the molecules. However, the substance is judged not to be classified into upper class "Explosives" since the substance is classified into Division 5.1 in UNRTDG (UN1479: OXIDIZING SOLID, N.O.S.) (ICSC (J) (2004)), further monohydrate is classified into Division 5.1, PG III in UNRTDG (UN3377) and is considered to be a practical oxidizing substance.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (J) (2004))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	No data are available though there are chemical groups (-O-O-) associated with explosive properties present in the molecules. However, the substance is judged not to be classified into upper class "Self-reactive substances and mixtures" since the substance is classified into Division 5.1 in UNRTDG (UN1479: OXIDIZING SOLID, N.O.S.) (ICSC (J) (2004)), further monohydrate is classified into Division 5.1, PG III in UNRTDG (UN3377) and is considered to be a practical oxidizing substance.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (J) (2004))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (J) (2004))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is considered to be stable against water since data are available that water solubility is 2.3 g/100 mL (20 degC) (ICSC (2004)) though it contains metals (Na) and metalloids (B).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available. Information is available that the substance is "Strong oxidizing agent (HSDB (2006)) and "Reacts with combustible or reducing substances" (ICSC (J) (2004))". It is classified into Division 5.1, PG III in UNRTDG (UN3377: SODIUM PERBORATE MONOHYDRATE). From the above, GHS Classification is not applicable though the substance is judged to be oxidizable.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of 2100 mg/kg and 2250 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Although a LC50 value was >0.074 mg/L as dust (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)), the exposure period was not clear. Classification was not possible since determination of category was impossible.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on results of "non-irritating" in 4-hour application skin irritation tests with rabbits and guinea pigs (PATTY (5th, 2001)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In a rabbit eye irritation test (OECD TG405), cornea opacity, iritis, conjunctiva redness, chemosis and discharge were observed and cornea opacity persisted up to day 21 in 4/6 rabbits. The MMAS (Modified Maximum Average Score) was 30.5 (ECETOC TR48 (1998)). Additionally, an another rabbit eye irritation test resulted in "severe irritation" (PATTY, (5th, 2001), and the substance is classified into R41 in EU classification (EU-Annex I (Access on Sep. 2009)). Based on these information, the substance was classified into Category 1. As relevant information, the effects are alleviated by dilution, the diluted substance was reported to be "not irritating" or "slightly irritating" (PATTY (5th, 2001), ATSDR (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is a report that parental toxicity, increased embryo resorptions, and cardiovascular and skeletal malformations were observed at a limit dose level when sodium perborate tetrahydrate was administrated to rats (Birth Defects (3rd, 2000)). Since these malformations were observed at dose levels at which toxicity was manifested in parental animals and the substance is classified into Repr. Category 2; R61 and Repr. Category 3; R62 in EU classification (EU-AnnexⅠ (access on Aug. 2009)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a report that in a 28-day test in rat given at an oral dose of 1000 mg/kg/day (90-day equivalence: 311 mg/kg/day), histological changes in the stomach were observed that are probably attributable to the formation of hydrogen peroxide in the stomach (PATTY (5th, 2001)). In addition, there is a report that repeated oral use as a mouthwash or the ingestion of tablets and powders marketed as denture cleansers has caused injuries (HSDB (2006)). This information is not used as the basis of classification for specific target organ toxicity since they are considered to be effects by site of contact.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 48h-EC50 = 6.98 mg/L for Crustacea (Ceriodaohnia dubia) (AQUIRE, 2010)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and the behavior in water is unknown as it is inorganic compound.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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