NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	10544-72-6
Chemical Name	dinitrogen tetraoxide
Substance ID	m-nite-10544-72-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	The substance, as dangerous transport goods, is treated as a gas (UN-1067) and is not explosive.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified	- -	-	-	Nonflammable (Hommel (1996); Weiss (1986)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Category 1	Danger	H270	P370+P376 P220 P244 P403	The substance is described as nitrogen dioxide in ISO-10156-2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Low pressure liquefied gas	Warning	H280	P410+P403	Its critical temperature is 158degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	It is a gas (GHS definition) and nonflammable (Hommel (1996); Weiss (1986)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	The substance, as dangerous transport goods, is treated as a gas (UN-1067) and is not a self-reactive chemical product.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	It is a nonflammable (ERG (2008); Hommel (1996)) gas (GHS definition) that does not ignite spontaneously in contact with air at ordinary temperature.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Classification not possible	- -	-	-	Its LC50 values have been documented: 29 ppmV for rats, 50.1 ppmV for mice, and 84.3 ppmV for rabbits (RTECS (2008)). However, these datasets are insufficient since administration durations associated with these LC50 values are not provided.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Since its skin corrosivity is documented in humans (HSDB (2002)), and it is rated as C; R34 in the EU classification, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since it is rated as C; R34 in the EU classification and it is known as a skin corrosive substance (HSDB 2002), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	In vivo chromosomal aberration tests using mouse spermatocytes (in vivo mutagenicity tests using germ cells) found negative results, while in vivo chromosomal tests using rat pneumocytes (in vivo mutagenicity tests using somatic cells) and in vivo DNA damage tests using mouse pnemocytes (in vivo genetic toxicity tests using somatic cells) found positive results (EHC 188 (1997)). Since in vivo genetic toxicity tests using germ cells are not available, the substance was classified into Category 2. Also, both Ames tests and in vitro mutagenicity tests using Chinese hamster cells also gave positive results (EHC 188 (1997)). In these toxicity tests, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)). Thus, these results are considered to be of NO2, and not of N2O4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	There is no sufficient information to use as grounds for determining if NO2 exposure has a direct link to carcinogenicity. The toxicity test datasets considered were of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	The cases of Silo Filler's disease, an occupational pulmonary disease associated with acute exposure to NO2, were documented (HSDB (2002)). Also, symptoms such as nasal irritation, bronchospasm, bronchiolitis obliterans, and pulmonary fibrosis were observed in humans (HSDB (2002)). In addition, pulmonary edema with possible subacute lesions in the lungs was suggested to occur in humans who are exposed to 50 ppm for 60 minutes (HSDB (2002). Based on this information on human toxicity, the substance was classified into Category 2 (respiratory system). Also, there are reports on respiratory symptoms such as pulmonary edema that developed in rats, mice or rabbits (RTECS (2008)). These reports are based on the effects of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In inhalation tests using rabbits that were exposed to the substance 24 hours a day for 3 to 4 months (> 90 days), emphysema was documented to occur at the doses of 8 or 12 ppm (EHC 188 (1997)). These doses fall under the range of corrected guidance values for Category 1 (<= 12.5 ppm). In addition the cases of Silo Filler's disease, an occupational pulmonary disease (HSDB (2002)) were documented, and symptoms such as nasal irritation, bronchospasm, bronchiolitis obliterans, and pulmonary fibrosis were observed in humans (HSDB (2002)). These reports are based on the effects of NO2, and not of N2O4, because N2O4 is the dimer of NO2, formed in equilibrium with NO2 molecules under the atmospheric pressure, and it readily disassociates to NO2 (EHC 188 (1997)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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