NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	106-47-8
Chemical Name	p-Chloroaniline
Substance ID	m-nite-106-47-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Classified as "flammable" by ICSC (2002). Classified into Division 6.1 (UN#2018 (Chloroaniline (solid))) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Not pyrophoric when in contact with air at ordinary temperatures; the auto-ignition temperature is 685degC (ICSC, 2002)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available - melting point: 69-72.5degC, test temperature: 140degC	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on the testing data of rat LD50 (oral route) of 300mg/kg (MOE Risk Assessment vol. 2 (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on the testing data of rabbit LD50 (dermal route) of 360mg/kg (CERI Hazard Data 2000-30 (2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on the rat LC50 value of 448ppm, calculated from the testing data of rat LC50 (4-hour inhalation) of 2.34mg/L (MOE Risk Assessment vol. 2 (2003)) exceeded the saturated vapour concentration (20ppm) under a saturated vapour pressure of 2.0kPa (20degC), the substance was classified based on the mist/dust classification.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on the description in the report on rabbit skin irritation tests (4-hour application) performed in accordance with OECD Guidelines (CICAD 48 (2003)): Non-irritating.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Guidelines (CICAD 48 (2003)): slightly irritating.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on the description in the report on guinea pig skin irritation tests (CICAD 48 (2003)) - Single injection adjuvant tests (conducted based on the maximization method) show 50% positive and 30% positive. The substance is considered to cause skin sensitization.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, positive data on somatic cell mutagenicity tests in vivo (micronucleus tests) and the absence of data on germ cell genotoxicity tests in vivo, described in CICAD 48 (2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Due to the fact that the substance is classified as Group 2B by IARC (1993).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (blood system, central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Based on the human evidence including "methemoglobinemia, cyanosis, lethargy, somnolency, headache, dizziness" (CERI Hazard Data 2000-30 (2001)), and the evidence from animal studies including "cyanosis, an increase in methemoglobin levels, formation of Heinz bodies (CERI Hazard Data 2000-30 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	Based on the human evidence including "cyanosis, an increase in methemoglobin/sulfhemoglobin levels" (CICAD 48 (2003)) and the evidence from animal studies including "cyanosis, formation of Heinz bodies, a significant decrease in hemoglobin and red blood cell counts" (CICAD 48 (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.31 mg/L for crustacea (Daphnia magna) (Ecotoxicity tests, Environment Agency, 2000; Result of the initial environmental risk assessment of chemicals, Vol. 8, Ministry of the Environment in Japan, 2006; Initial Risk Assessment Report, NITE, 2007), it was classified in Category 1.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	It was classified in Category 1 from lack of rapid degradability (a degradation rate by BOD: 0% (the existing chemicals survey program, 1990)), and 21-day NOEC = 0.0032 mg/L for crustacea (Daphnia magna) (Result of the initial environmental risk assessment of chemicals, Vol. 8, Ministry of the Environment in Japan, 2006; Initial Risk Assessment Report, NITE, 2007).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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