Item | Information |
---|---|
CAS RN | 106-97-8 |
Chemical Name | n-Butane |
Substance ID | m-nite-106-97-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
It was classified in Category 1 from explosion limits (1.8-8.4% (ICSC (2003))). Besides, it is classified in Division 2.1 in UNRTDG (UN1011). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It was classified as "Not classified" because it was classified as flammable gases. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Low pressure liquefied gas |
Warning |
H280 | P410+P403 | It was classified as low-pressure liquefied gases from the information that it is partially liquid at temperatures above -50 deg C, and a critical temperature is about 152 deg C (Hommel (1991)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to gas substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LC50 for rats (4 hours): 276,798.8 ppm (DFGOT vol.20 (2003), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 1988), BUA 144 (1994), HSDB (Access on June 2019)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), since it is a gas at normal temperature, it was classified as "Not classified." [Evidence Data] (1) Gas (GHS definition). [Reference Data, etc.] (2) Liquefied n-butane may cause chemical freezing on the skin and eyes (DFGOT vol.20 (2003), PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), since it is a gas at normal temperature, it was classified as "Not classified." [Evidence Data] (1) Gas (GHS definition). [Reference Data, etc.] (2) This substance is not irritating to the eyes of rabbits (DFGOT vol.20 (2003)). (3) Liquefied n-butane may cause chemical freezing on the skin and eyes (DFGOT vol.20 (2003), PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There are no in vivo data of this substance itself. Therefore, it was classified as "Classification not possible" in accordance with the GHS Classification Guidance for the Japanese Government. [Reference Data, etc.] (1) As for in vivo, there is a report of a positive result in a mouse erythrocyte micronucleus test by inhalation exposure to domestic cooking gas containing this substance (PATTY (6th, 2012)). However, it was not reproducible in a confirmatory test, which gave a negative result (McKee et al, Int J Toxicol., 33 (1) suppl, 28S-51S, 2014). (2) As for in vitro, there is a report of a negative result in a bacterial reverse mutation test (DFGOT vol.20 (2003), PATTY (6th, 2012), ACGIH (7th, 2017)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), no effects were observed on reproduction and development, however, this test was a screening test and there were no data on developmental toxicity tests. Therefore, it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) A combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by inhalation exposure was conducted. No toxicologically important changes were observed in parental animals, and no reproductive or developmental effects were observed (McKee et al, Int J Toxicol., 33 (1) suppl, 28S-51S, 2014). [Reference Data, etc.] (2) A woman who suffered severe intoxication with butane gas in Week 27 of gestation (no other details), gave birth to a child with hydranencephaly. The authors suspect that the malformation was caused by intrauterine anoxia during development of the fetal brain (DFGOT vol.20 (2003)). (3) A woman who attempted suicide with butane gas in week 30 of gestation, gave birth to a child that died 11 hours after the birth. Severe multi-cystic encephalomalacia was diagnosed. It was considered not to be a substance-specific effect of butane gas, but damage caused by maternal anoxia (DFGOT vol.20 (2003)). (4) It is described in PATTY (6th, 2012) that both of the above case reports suggest that butane exposure to pregnant women can cause significant neurodevelopmental damage to the fetus. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on reports of narcotic effects on humans and animals in (1)-(4), it was classified in Category 3 (narcotic effects). [Evidence Data] (1) As for humans, there is a report that dizziness was observed after inhalation at 10,000 ppm of this substance for 10 minutes (DFGOT vol.20 (2003)). (2) There is a description that the concentration where narcotic effects to humans by this substance is produced is 17,000 ppm (DFGOT vol.20 (2003)). (3) There is a report that euphoria and hallucinations were observed in most of 12 persons who repeatedly inhaled butane gas (DFGOT vol.20 (2003)). It is considered that these effects were probably observed also on first inhalation exposure. (4) As for mice, there is a report that anesthetic action was observed after inhalation at 130,000 ppm of this substance for 25 minutes (ACGIH (7th, 2001), DFGOT vol.20 (2003), PATTY (6th, 2012)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 1 (central nervous system). The classification result was changed from the previous classification by the addition of the new information sources. [Evidence Data] (1) Severe brain damage developed in a 15-year-old girl who abused butane gas from lighter refill cans for 4 weeks, and neurological complications developed after hospitalization. As a result of MRI scans, disintegrating gray matter and cerebral atrophy, etc. were observed (PATTY (6th, 2012)). (2) There are some reports that neurological symptoms such as visual or auditory hallucinations developed in young men and women who abused butane gas (PATTY (6th, 2012)). (3) There is a report that euphoria and hallucinations were observed in most of 12 persons who repeatedly inhaled butane gas (DFGOT vol.20 (2003)). [Reference Data, etc.] (4) Significant neurological effects and deaths due to butane gas abuse were reported. Most of the victims were young men, and deaths were attributed to hypoxia and cardiac failure (ACGIH (7th, 2017)). (5) In 22 workers exposed to 8,000 mg/m3 in a liquid gas filling station of propane and butane, a dry throat, a dry cough, severe agitation and dizziness are reported. As a result of electrocardiography, tachycardia, extrasystoles and incomplete right bundle-branch block were observed (DFGOT vol.20 (2003), ACGIH (7th, 2017)). (6) A 28-year-old man who filled butane and propane gases was admitted to the hospital complaining of nausea, etc. He was diagnosed with acute hepatitis, likely due to chronic exposure to butane and propane (PATTY (6th, 2012)). (7) Butane and isobutane increase the sensitivity of the heart muscle to adrenaline (mechanism is unknown) (DFGOT vol.20 (2003)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Gas (GHS definition) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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